ID F6PLW9_CALJA Unreviewed; 405 AA.
AC F6PLW9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=B box and SPRY domain-containing protein {ECO:0000313|EMBL:JAB09542.1};
DE SubName: Full=B-box and SPRY domain containing {ECO:0000313|Ensembl:ENSCJAP00000056272.1};
GN Name=BSPRY {ECO:0000313|EMBL:JAB09542.1,
GN ECO:0000313|Ensembl:ENSCJAP00000056272.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB09542.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000056272.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB09542.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB09542.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000056272.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Can form homodimers and homotrimers. In addition to lower-
CC order dimerization, also exhibits a higher-order multimerization and
CC both low- and high-order multimerizations are essential for its
CC restriction activity. Interacts with BTBD1 and BTBD2. Interacts with
CC PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain)
CC with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3.
CC Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with
CC ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A,
CC MAP1LC3C and BECN1. {ECO:0000256|ARBA:ARBA00011109}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAMT01002319; JAB09542.1; -; mRNA.
DR RefSeq; XP_002743262.1; XM_002743216.4.
DR STRING; 9483.ENSCJAP00000056272; -.
DR Ensembl; ENSCJAT00000070538.3; ENSCJAP00000056272.1; ENSCJAG00000041274.3.
DR GeneID; 100392859; -.
DR KEGG; cjc:100392859; -.
DR CTD; 54836; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000161096; -.
DR HOGENOM; CLU_050384_0_0_1; -.
DR OMA; HESELDW; -.
DR OrthoDB; 5296458at2759; -.
DR TreeFam; TF351014; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000041274; Expressed in kidney and 4 other cell types or tissues.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd19834; Bbox2_BSPRY; 1.
DR CDD; cd12904; SPRY_BSPRY; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR PANTHER; PTHR24103:SF568; B BOX AND SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 215..405
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 405 AA; 44823 MW; 9E08E64899D4981F CRC64;
MSAEGSTGPG PGSEPGRGPE PGPLCPEHGQ ALSWFCGSER RPVCAACTGL GGRCRGHRIR
PAEERAEELR NKIVDQCERL QLQSAGISKY VADVLPGKNQ RAVSMASAAR EKVIQRLSLV
RSLCESEEQR LLEQVHGEEE RAHQSILTQR VHWAEALQKL DTIRTGLVGM LTHLDDLQLI
QKEQEIFERT EEAEGILDPQ ESEMLNFNEK CTRSPLLTQL WATAVLGSLS GTEDIRIDER
TVSPFLQLSD DQKTLTFSTK KSKPCADGPE RFDHWPNALA ATSFQDGLHA WIVNVQNSCA
YKVGVASGHL PRKGSGSDCR LGHNAFSWVF SRYDQEFRFL HNGQHEPLGL LRGPAQLGVL
LDLQARELLF YEPASGTVLY THHGAFTGPL FPVFAVADQT ISIIR
//
