ID F6PRT5_HORSE Unreviewed; 1597 AA.
AC F6PRT5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Calmodulin regulated spectrin associated protein 1 {ECO:0000313|Ensembl:ENSECAP00000015027.3};
GN Name=CAMSAP1 {ECO:0000313|Ensembl:ENSECAP00000015027.3,
GN ECO:0000313|VGNC:VGNC:16027};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015027.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000015027.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015027.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000015027.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015027.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR Ensembl; ENSECAT00000018419.3; ENSECAP00000015027.3; ENSECAG00000017095.3.
DR VGNC; VGNC:16027; CAMSAP1.
DR GeneTree; ENSGT00950000182975; -.
DR TreeFam; TF315529; -.
DR Proteomes; UP000002281; Chromosome 25.
DR Bgee; ENSECAG00000017095; Expressed in retina and 23 other cell types or tissues.
DR ExpressionAtlas; F6PRT5; baseline.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF3; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 216..331
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1458..1592
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 348..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1067..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1187..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1424..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 866..896
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 355..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1429..1443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1597 AA; 176932 MW; F251ECA16F596AA6 CRC64;
MVDAGGGAAG EGWRRMEAAP DGAVDIVPLD RYDPARAKIA ANLQWICAKA YGIDNIPEDL
RDPFYIDQYE QEHIKPPVIK LLLSSELYCR VCSLILKGDQ VAALQGHQSV IQALSRKGIY
VMESDDTPVT DPDLSRAPIK MSAHMAMVDA LMMAYTVEMI SIEKVVASVK RFSTFSASKE
LPYDLEDAMV FWVNKVNLKM REITEKEVKL KQQLLESPAR QKVRYRREHL SARQPPCFPL
LEDLMRDSSD GAALLAVVHF YCPEQMKLDD ICLKEVTSMA DSLYNIRLLR EFSNEYLNKC
FYLTLEDMLY APLVLKPNVM VFIAELFWWF ENVKPDFVQP RDVQELKDAK TVSHQKSSRP
PVPISNATKR SFLGSPAAAS PADLQSSTQL PAEGCPRHHL HPEESEHLGK GASAFSPSHP
LLPLRQKQQK TMQGEECPDQ RHRSNSLTRV DGQPRGAAAA WAEKKNRPVS QPAPVALHHA
ASCDLDPGSG DSVSLARSIS KDSLASNIVN LTPQNQPHPT ALKTNGKSLL NNVDIEDEDE
ELVAIIRTDV APHSGDLGLM ASARSPQRLA DTLESKPDSF FLEPLMPAVL RPAKEKQMIT
KEDECGEGRP RSFTSKRSSE GYQPLLRKKA SSGHVSRDLN RTFTPICSEL PVGLDPVPAE
AGPQVVGEAC GRPLASGGFD PLSQGQSADG FFLHVARAEE DTEGRFYVSC AKSPNAHHPE
PWTVLRQDSD SDIADLEEAE HDLLGEDHPV VITKYVGEEE SAKLQEDLKV KEHEDKDDAS
GRSSPCLSTV SQISSVSMAS GSVKMTSFAE RKLQRLNSCE TKSSTSSSQK TTPDGSESCP
PPLTTWKQRR EQSPSRQSKD HASLLASELV QLHMQLEEKR RAIEAQKKKM ETLSARQRLK
LGKAAFLHVV KKGKADVVPQ PLKPEHFARE YSQHNGEDFD GGVSKMEEFL VKEEGREDLL
SESQDVDRES LAFIQQHKPK DPATLHDLEK HKALSAALLE DSAGEVGDVS ECDLSIEKLN
ETISTLQQAI LKISQQQEQL LMKSPTAPAP GSKNNSQDQR VKTAIHFVEP LSPTGVTGHR
KPPRLGQGRN SRSGRPADLK VPKDRQQGSS RSKTPTPSIE TLPHLRSFPP RTPSDPGWDG
GADPGSDPQE KCFFDSYRLH DESNQRTFVL SSSKDANIIL EQTSLKEALD GGEKEAGLSA
PAGSGKENGP VDEPPRSKAS LIEVDLSDLK APDEDGETEG HESSVDLSTD GDQKPGVGFF
FKDEQKAEDE LAKKRAAFLL KQQRKAEEAR VRKQQLEAEV ELKRDEARRK AEEDRIRKEE
EKARRELIKQ EYLRRKQQQI LEEQGLGKPK SKPKKPRPKS VHREESCSDS GTKCSSTPDN
LSRAQSGSSL SLASAATTEP ESVHSGGTPS QRCPEELGRV ESLEALPVLS RNPSRSTDRD
WETASAASSL ASVAEYTGPK LFKEPSSKSN KPIIHNAVSH CCLAGKVNEP HKNSILEELE
KCDANHYIIL FRDAGCQFRA LYCYYPDTEE IYKLTGTGPK SITKKMIDKL YKYSSDRKQF
NLIPAKTMSV SVDALTIHNH LWQPKRPAAP KKTQTRK
//
