ID F6Q6R1_MOUSE Unreviewed; 96 AA.
AC F6Q6R1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Isoleucine-tRNA synthetase {ECO:0000313|Ensembl:ENSMUSP00000130204.2};
DE Flags: Fragment;
GN Name=Iars1 {ECO:0000313|Ensembl:ENSMUSP00000130204.2,
GN ECO:0000313|MGI:MGI:2145219};
GN Synonyms=Iars {ECO:0000313|MGI:MGI:2145219};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000130204.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000130204.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130204.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000130204.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130204.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6Q6R1; -.
DR SMR; F6Q6R1; -.
DR jPOST; F6Q6R1; -.
DR MaxQB; F6Q6R1; -.
DR PeptideAtlas; F6Q6R1; -.
DR ProteomicsDB; 345483; -.
DR Antibodypedia; 28131; 150 antibodies from 21 providers.
DR Ensembl; ENSMUST00000171510.2; ENSMUSP00000130204.2; ENSMUSG00000037851.14.
DR AGR; MGI:2145219; -.
DR MGI; MGI:2145219; Iars1.
DR VEuPathDB; HostDB:ENSMUSG00000037851; -.
DR GeneTree; ENSGT00550000074921; -.
DR HOGENOM; CLU_2365032_0_0_1; -.
DR ChiTaRS; Iars; mouse.
DR Proteomes; UP000000589; Chromosome 13.
DR Bgee; ENSMUSG00000037851; Expressed in primary oocyte and 284 other cell types or tissues.
DR ExpressionAtlas; F6Q6R1; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR023586; Ile-tRNA-ligase_type2.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR42780:SF1; ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR42780; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 1: Evidence at protein level;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Proteomics identification {ECO:0007829|EPD:F6Q6R1,
KW ECO:0007829|MaxQB:F6Q6R1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1..88
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000130204.2"
SQ SEQUENCE 96 AA; 11584 MW; 0E8EC68E5282CA6B CRC64;
YKSVPSWFVR VEPMVDQLLK NNDLCYWVPE FVREKRFGNW LKEARDWAIS RNRYWGTPIP
LWVSEDLEEC ALDQWQSLKN CREQKSQIST ERASTT
//
