ID F6QDA1_XENTR Unreviewed; 881 AA.
AC F6QDA1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=SLIT and NTRK like family member 5 {ECO:0000313|Ensembl:ENSXETP00000047546};
DE SubName: Full=SLIT and NTRK-like protein 5 {ECO:0000313|RefSeq:XP_002940152.1, ECO:0000313|RefSeq:XP_004911883.1};
GN Name=slitrk5 {ECO:0000313|Ensembl:ENSXETP00000047546,
GN ECO:0000313|RefSeq:XP_002940152.1, ECO:0000313|RefSeq:XP_004911883.1,
GN ECO:0000313|Xenbase:XB-GENE-6034846};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000047546};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000047546}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000047546};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000047546}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002940152.1, ECO:0000313|RefSeq:XP_004911883.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002940152.1,
RC ECO:0000313|RefSeq:XP_004911883.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002940152.1,
RC ECO:0000313|RefSeq:XP_004911883.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLITRK family.
CC {ECO:0000256|ARBA:ARBA00010439}.
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DR RefSeq; XP_002940152.1; XM_002940106.5.
DR RefSeq; XP_004911883.1; XM_004911826.3.
DR Ensembl; ENSXETT00000047546; ENSXETP00000047546; ENSXETG00000023987.
DR GeneID; 100494014; -.
DR KEGG; xtr:100494014; -.
DR AGR; Xenbase:XB-GENE-6034846; -.
DR CTD; 26050; -.
DR Xenbase; XB-GENE-6034846; slitrk5.
DR eggNOG; ENOG502QUVV; Eukaryota.
DR HOGENOM; CLU_012706_1_0_1; -.
DR OMA; LTGEMFF; -.
DR OrthoDB; 5309131at2759; -.
DR TreeFam; TF326378; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Bgee; ENSXETG00000023987; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IEA:InterPro.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773; SLIT AND NTRK-LIKE PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR45773:SF5; SLIT AND NTRK-LIKE PROTEIN 5; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 649..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 235..285
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 559..609
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 324..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 100209 MW; 9CB69C938E96547D CRC64;
MYHCCSPVTF DQDLSKKMQM WILQTIAFAV TSLVLSWAET IEYYGEVCDH SCPCEERDGI
LTVNCENRGI ISLSEISPPR FPVYHLLLFG NLLNRLYLNE FVNYTGASIL HLGNNDIQDI
ETGAFNGLQG LKRLHLNNNK LELLKNDTFI GLQNLEYLQV DYNFIISIEP NTFSRLHSLQ
VLILNDNLLS TLPTNLFRFV PLTHLDLRGN RLKVLPYVGL LEHMDKVVEL QLEENPWNCS
CELIALKDWL YSISYSALVG DVVCETPFRL YGRDLDEISK QELCPRKLIS IYEMRPQIPR
STSEYFHTTP ASVNSGATIS SSVYKNLTKP KSTRQPNRSK GRTTSHRPPI DSGYSISIAY
QTKSPVPLEC PTNCTCNLQI SNLGLNVNCQ ERKIQSISDL HPKPYNPKKM YLTGNYIALV
RRTDFIDSTG LDLLHLGNNR ISVIQDRAFG DLTNLRRLYL NGNSIEKLTP ELFYGLQSLQ
YLFLQYNSIK EIEPGTFNFV PNLHLLFLNN NLMKHLPSNI FSGLNLSRLN LRSNLFSHLT
VSGGLDQLKS LVQIDLHENP WDCTCNVLGM KLWLEQLSVG VLVDDVICKS PPNFALKEMR
AIKPELLCPD HSAMEATTST PSPVLPSEST TALIHPSKFN NNSSSSVPLS VLILSLLLVF
IMSVFVAAGL FVLVMKRRKK NQNDPASTNN SDVSSFNMQY SVYSNRPLPK VKTPAGHVYE
YIPHPLGHMC KNPIYRSREG NSVEDYKDLH ELKVTYRDHL EEERDSSLRG TSYSVSTIES
RVELSPVQDT DRVYRGILEP DKGPSPGPNI DYKYSNPNTF TYAPKRQFLH PDRLREAMLY
STPSTVYVEP NRNEYLELKA KLNVEPDYLE VLEKQTTFSQ F
//
