ID F6QDT9_CIOIN Unreviewed; 593 AA.
AC F6QDT9; A0A1W2WLN9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Tyrosine-protein kinase RYK {ECO:0000313|Ensembl:ENSCINP00000018455.3};
GN Name=LOC100177957 {ECO:0000313|Ensembl:ENSCINP00000018455.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000018455.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000018455.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; EAAA01000092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002129769.1; XM_002129733.4.
DR AlphaFoldDB; F6QDT9; -.
DR STRING; 7719.ENSCINP00000018455; -.
DR Ensembl; ENSCINT00000018455.3; ENSCINP00000018455.3; ENSCING00000009096.3.
DR GeneID; 100177957; -.
DR KEGG; cin:100177957; -.
DR GeneTree; ENSGT00940000155119; -.
DR HOGENOM; CLU_000288_7_36_1; -.
DR InParanoid; F6QDT9; -.
DR OMA; PQEPQTW; -.
DR OrthoDB; 1614410at2759; -.
DR TreeFam; TF317402; -.
DR Proteomes; UP000008144; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.60.40.2170; Wnt, WIF domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR003306; WIF.
DR InterPro; IPR038677; WIF_sf.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF349; TYROSINE-PROTEIN KINASE RYK; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF02019; WIF; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00469; WIF; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50814; WIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..593
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014089903"
FT TRANSMEM 208..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..172
FT /note="WIF"
FT /evidence="ECO:0000259|PROSITE:PS50814"
FT DOMAIN 309..586
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 593 AA; 66405 MW; 6DF51094BB037E6F CRC64;
MRVCAYILAV VLLPCMSKCS IDLYLAEDQV EKLFGIADAE MYYIRNGIIN ENAVNFVAHV
QPEHTDLTYL WKVTNKAITV AYDLDILDVQ KSPAQLNTGS VEMNKHSILY PPKLESKSGT
IRYSEDLQPQ TLKVSLVCTG EREGNVTVTM KLKLVMDSGT DLVVNIKRLK KCLKTHSFVE
DKPVLTDQPS EPNDQDLNLG GTQQSTSAFY ISVSVVSSFI VLIVVGVTLW HVRMSKRYQR
SGVDNCIPMQ PGAQHLNQFL RPDLPNNALK PPSHSSLMQI ITPLINDLGT DINEIQSKLS
AIAIPRENVD IGELTLKGTF ARIYKGTLDD GTPVLIKTVS DMATEEQKRL LLFESSLLRG
MHHRNLLSMK HVVLQDDSTP PMVLFHFMEG GNLKHYLQGL KLKESPGLVS GIFGSGSTKY
EQVSTQDLVE MAIQIACGMT YLSKRGLVHK DLAARNCVID RDLKVKISDN ALSRDAFPAD
YCCLGDNENR PVRWLGLESL VHKVYSSASD VWSFGVLLWE LQSLAATPYA DIDDFEMASY
LKDGFRLSQP INCPDHLYSI IASCWHYSPD QRPSFTKLLQ MLTEFYAELE VYV
//
