ID F6QM13_HORSE Unreviewed; 1704 AA.
AC F6QM13;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=BCL6 corepressor like 1 {ECO:0000313|Ensembl:ENSECAP00000043124.2};
GN Name=BCORL1 {ECO:0000313|Ensembl:ENSECAP00000043124.2,
GN ECO:0000313|VGNC:VGNC:15802};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000043124.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000043124.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043124.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000043124.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043124.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BCOR family.
CC {ECO:0000256|ARBA:ARBA00034703}.
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DR Ensembl; ENSECAT00000059049.2; ENSECAP00000043124.2; ENSECAG00000025037.4.
DR VGNC; VGNC:15802; BCORL1.
DR GeneTree; ENSGT00940000153737; -.
DR HOGENOM; CLU_003920_0_0_1; -.
DR OrthoDB; 296979at2759; -.
DR Proteomes; UP000002281; Chromosome X.
DR Bgee; ENSECAG00000025037; Expressed in trophectoderm and 23 other cell types or tissues.
DR ExpressionAtlas; F6QM13; baseline.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR CDD; cd14260; PUFD_like_1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.10.260.40; BCL-6 corepressor, PCGF1 binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047144; BCOR-like.
DR InterPro; IPR032365; PUFD.
DR InterPro; IPR038227; PUFD_som_sf.
DR PANTHER; PTHR24117; AGAP007537-PB; 1.
DR PANTHER; PTHR24117:SF6; BCL-6 COREPRESSOR-LIKE PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF16553; PUFD; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REPEAT 1457..1489
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1586..1702
FT /note="BCL-6 corepressor PCGF1 binding"
FT /evidence="ECO:0000259|Pfam:PF16553"
FT REGION 63..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1348..1382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..578
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1704 AA; 181513 MW; BEFF6B5A69AD7D09 CRC64;
MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GDCQRFGSQE FCVSSSFSKV
ELTAVGSGSN ARGADPDGSA TEKLGHKSED KPDDPQPKMD YAGNVAEAEG LLVPLSSPGD
GLKPPAADST EASSSRADSS WTPLSTQMSK QVDCSPAGVK ALDSRQGVGE KNTFILATLG
TGVPVEGTLP LVTTNFSPLP APICPPAPSS ASVPPSVPDQ FQVPLSVPAP VPHSGLVPVQ
VATSVPAPSP PLAPVPALAP APPSVPTLIS DSNPLSVSAS VLVPVPASAP PSGPVPLSAP
APTPISVPVS APPLALIQAP VPPSAPTLVL APVPTPVLAP MPASTPPAAP APPSVPMPTP
TPSSGPPSTP TLIPAFAPTP VPAPTPAPIF TPAPTPMPAA TPTAIPTSAP ISASFSLSRV
CFPAAQAPAM QKVPLSFQPG TVLTPSQPLV YIPPPSCGQP LSVATLPTTL GVSSTLTLPV
LPSYLQDRCL PGVLASPELR SYPYAFSVAR PLTSDSKLVS LEVNRLPCAS PSSSTSTQPA
PDGVSGPLAD TSLSTASAKV LPTPQPLLPA PSVSSAPPHP AKMPGGTEQQ TEGTSVTFSP
LKSPPQLERE MASPPECSEM PLDLSSKSNR QKLPLPNQRK TPPMPVLTPV HTSSKALLST
VLSRSQRTTQ AASSNVTSCL GSTSSPFVIF PEIVRNGDPS TWVKNSTALI STIPGTYVGV
ANPVPASLLL NKDPNLGLTR DPRHLPKQEP ISIIDQGEPK STGAPCGKKG SQAGTEGQPS
TVKRYTPARI APGLPGCQTK ELSLWKPTGP ANIYPRCSVN GKPTSTQVLP VGWSPYHQAS
LLSIGISSAG QLTPSQGVPI KPTSVVSEFS GVPSLGPSEA VHGLPEGQPR PGGPFAPEQD
TGTKNKTCRI AAKPYEEQVN PVLLTLSPQT GTLALSVQPS GGDIRVNQGP EESESHLCPD
GTPKMEGPQG ACGLKLAGDT KPKNQVLATY MSHELVLATP QNLRKMPELP LLPHDSRPKE
LILDVVPSGK RGSSTELSQL GSQVDLGRVK MEKVDGDVVF NLATCFRADG LPAAPQRGQA
EVRSKAGQAR VKQESIGVFA CKNKWQPDSV VTDGVTESLP PKKMKCSKEK DGEEPQPQAK
AIVRSSHGPK CRKPPSDPQE PTKKSPRGAP DSGKEHNGVR VKHKHRKPTK PESQSPGKRA
DGHEEGSLEK KAKSSFRDFI PVVLSTRTRS QSGSICSSFA GMADSDMGSQ EVFPTEEEEE
VTPTPAKRRK VRKTQRDTQY RSHHAQDKTL LNQGRRHLWR AREMPWRTEA ARQMWDTNEE
EEEEEEEGLV KRKKRRRQKS RKYQTGEYLT EQEEEQRRKG RADLKARKQK TSSQSSEHRL
RNRNLLLPNK AQGISDSPNG FLPNNLEEPA CLENSEKPSG KRKCKTKHMA NVSEEAKDVV
LYCLQKDSED VNHRDNAGYT ALHEACSRGW TDILNILLEH GANVKPVHDA VVNDNLETIW
LLLSYGADPT LATYSGQTAM KLASSDTMKR FLSDHLSDLQ GRAEGDPGVS WDFYSSSVLE
EKDGFACDLL HNPPGSSDQE GDDVEEDDFM FELSDKPLLP CYNLQVSVSR GPCNWFLFTD
VLKRLKLSSR IFQARFPHFE IATLPKAEFH RQVASSQLLT PAERPGGLDA RSAPGSSETV
ELVRYEPELL RLLGSQVEFQ PWNS
//
