ID F6QNL7_CIOIN Unreviewed; 1214 AA.
AC F6QNL7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Helicase domino {ECO:0008006|Google:ProtNLM};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000009715.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000009715.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; EAAA01001767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6QNL7; -.
DR STRING; 7719.ENSCINP00000009715; -.
DR Ensembl; ENSCINT00000009715.3; ENSCINP00000009715.3; ENSCING00000004687.3.
DR GeneTree; ENSGT00940000157457; -.
DR HOGENOM; CLU_000315_12_1_1; -.
DR InParanoid; F6QNL7; -.
DR OMA; THEEIGM; -.
DR TreeFam; TF106424; -.
DR Proteomes; UP000008144; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR CDD; cd18003; DEXQc_SRCAP; 1.
DR Gene3D; 1.20.120.850; SWI2/SNF2 ATPases, N-terminal domain; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45685:SF1; HELICASE SRCAP; 1.
DR PANTHER; PTHR45685; HELICASE SRCAP-RELATED; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00573; HSA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51204; HSA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 217..289
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 713..878
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 78..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1190..1214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..597
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..632
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1214 AA; 137703 MW; D181B03D2DF919F4 CRC64;
MVLNNHNDGT PATDASNSPV AEKRLGAIAI QEEKMKLCSE NYTELVTELF FLQHGGNYTE
FAQFKKRPSQ KLIDHLRQTP VFPNGDGRHK SSDARKASTD NDKLNTNKPE TKQPTVLSVE
TTPAASLSGN RPAYSPSRAP ANQGSVQSSP KLNDPTLPAS PSLTQRLKRQ SRNTLSDVYE
DTIGSQEEIL ERAKQEAVVQ RRVAELRKQG LWSQRRLPKV QEPPRNKTHW DYLLEEMRWL
AADFAQERKW KRAAARKVVR MVTAYHKDVR EKEKRVEREG QQKLRRIAAN MARQIRNFWS
NIEKVVEYKQ RSLLDEKRQK ALDLHLNFIV DQTAKYSDWL SQGLNQPSVE ASPSVSKSGS
QAGSDDDFLP QGASSDDEET IAVEEKDVKE EHVLDEIALL QKESEIPFED LLSQLPPDIV
QNVGAPLIDA SKDEDLPETK KEGEQIIEET LKEESPKPPE ATEESKPSPE KEDPTPQNEE
ALSSDDESNK PTPISLRRSA RKRQGDQDTE DEDAKRRKTE DNQDVEFDGE DESSSDDERT
LKEQEQTEDV DHDKEIADLQ AENELPIEEL MKMYQGYGEG GEEDAEDEPV EEKETVEPEP
EPDAKEGSDL GESSDEEAGE NDNDEEEETH EEIGMDYLLK ADLGNKEKEK DGEADASKVE
SSPNKEITDV AAEAMSLQPT GHTLATTQVV TPVPGLLKHT LREYQHIGLD WLVTMYVKRL
NGILADEMGL GKTIQTIALL AHLACDKGVW GPHLIVVPTS VMLNWEMEFK KWCPGFKILT
YYGSQKERKL KRTGWTKSNA FHVCITSYKL VLQDHTSFRR KKWRYLILDE AQNIKNFKSQ
RWQTLLNFNS QRRLLLTGTP LQNNLMELWS LMHFLMPHVF QSHREFKEWF SNPMTGMIEG
SQEFNEKIVR RLHKVLRPFL LRRIKKDVEK QMPNKYEHVV RCHLSKRQRF LYDDFMSRAS
TRETLAGGHF MSVINVLMQL RKVCNHPNLF ESRPTVSSFV TTPMTVCCPT IVAKAMEKSV
FETADLEYLN LYLPNLCKVA SYNVEERYAL KTPKKLIEEL DSTEEKKIEP LSHPANLNDR
IRSMVFERLF TSPHPLQQQK NASLLATRPA SRSGSPTLLQ QKLTSATNVT TTKSVGKSDT
TDITTSKSST SQSITLQYQT AQGTRWATIP NGQIRHLPGG VVQIVTTGVP SRSATPVPTQ
AALPATDRAS DTTA
//
