ID F6QNM8_ORNAN Unreviewed; 1146 AA.
AC F6QNM8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=BOC cell adhesion associated, oncogene regulated {ECO:0000313|Ensembl:ENSOANP00000009225.3};
GN Name=BOC {ECO:0000313|Ensembl:ENSOANP00000009225.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000009225.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000009225.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000009225.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000009225.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000009225.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6QNM8; -.
DR STRING; 9258.ENSOANP00000009225; -.
DR Ensembl; ENSOANT00000009227.3; ENSOANP00000009225.3; ENSOANG00000005789.3.
DR eggNOG; ENOG502QUNT; Eukaryota.
DR GeneTree; ENSGT00940000158810; -.
DR HOGENOM; CLU_008503_0_0_1; -.
DR InParanoid; F6QNM8; -.
DR OMA; KQTSDMC; -.
DR TreeFam; TF332268; -.
DR Proteomes; UP000002279; Chromosome 11.
DR Bgee; ENSOANG00000005789; Expressed in heart and 7 other cell types or tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR44170:SF3; BROTHER OF CDO; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF16625; ISET-FN3_linker; 1.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 866..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..147
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 156..237
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 258..328
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 347..431
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 496..593
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 630..726
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 734..834
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1060
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1146 AA; 122963 MW; 50BE3E5AEEAB362F CRC64;
MHQLFPGRLM GSGLPPNPPT PRRTLPLGVP MMPGRLRVAA PITCLLLAAT GCLAGMGEVP
RVSVLPASTV QKHGGPVVLH CEVEPPGTNV TWRHNGEELS AVSAALGIHV SRGTLLIAAL
RHDTVGRYQC VAHLPAGAVA SVPAPVTLAN LQDFKPDGQH VIEVDEGNTA IIACHLPESH
PKAQARYSVK HEWLEASRDN YLIMPSGNLQ IVNASHEDEG TYKCAAYNPV TQEVKTSGSS
DRLRVRRASA EAARIIYPRE AQTITVTRGQ SLVLECVASG APPPRVTWAK DGSSVGGYNN
TRFLLSNLLI DAATEQDSGT YRCMADNGVG EPGAAVILYR VQVFEPPEVT VELSRQVVLW
GQNARLACMV RGNPPPSLLW LHNAVPLAPS QRLSLAGGTL WLAGVGPLDD GLYQCMAENE
VGSAQAMVQL RTARPGSTFA PQQVSGVGWT LPPATPSMPP DQVPSGTASL LQPRPTTLTA
SGPCLSGEGQ AVPAEAPVIL SSPRTPRTDS YELVWRPRHD GGSRAPVLFY VVKHRKAANS
SGNWTVSEIP GHQHRLPLTR LDPGSLYEVE VAAHNCAGVG QTAMVTFRTG RRPKPEIIAG
KEQQVQRDDP AAGMKSSVLP DNSRLSPPEA PDRPTISTAS ETSVYVTWIP RGNGGFPIQS
FRVEARKLKK VGDWVPASSA IPPSRLSVEI AGLEKGTSYK FRVRAMNILG ESRPSAASRP
YLVSGSGSRS YERPVAGPHI TFTEAVNETT IMLKWMYIPA SNNHTPIHGF FIYYRPTDSD
NDSDYKKDVV EGDRYWHSIS QLQPETSYDI KMQCFNEGGE SDFSNVMICE TKARKYPVLP
GRPPPPTLAL PKQPPPFAIV ARSSDLPYLI VGVVLGSVVL LIVAFIPFCL WRAWSKQKHT
TDLGCPGPSL LTASCQYTLV PLRAIAPSRA SGLPRSGGCP ATDPHDYSPA HLQQLAPCTE
GENQGALCLS PGPTPARLAH CPLPVQPPLS GLEAGQWGSK LGPGPAPLNP PDPRTDTCES
RPFPDPGSPA PTHQLPGPQG EGHRHQEPAM ADRDDSENPR SEALWDTLFL SGQLLLHQPN
ILSGLPVNLF ADPGVQLKLL HGGRLWQVNS WFSLAPEARE LQASPNGGQV PGSIIGIPPE
TISTMC
//
