ID F6QQZ5_HORSE Unreviewed; 204 AA.
AC F6QQZ5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=TIR domain containing adaptor protein {ECO:0000313|Ensembl:ENSECAP00000010139.3};
GN Name=TIRAP {ECO:0000313|Ensembl:ENSECAP00000010139.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010139.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010139.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010139.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010139.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010139.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6QQZ5; -.
DR STRING; 9796.ENSECAP00000010139; -.
DR PaxDb; 9796-ENSECAP00000010139; -.
DR Ensembl; ENSECAT00000012827.4; ENSECAP00000010139.3; ENSECAG00000049250.1.
DR GeneTree; ENSGT00510000048428; -.
DR HOGENOM; CLU_091033_1_0_1; -.
DR InParanoid; F6QQZ5; -.
DR OMA; RWKRKYD; -.
DR TreeFam; TF330734; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000012390; Expressed in leukocyte and 23 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0035663; F:Toll-like receptor 2 binding; IBA:GO_Central.
DR GO; GO:0035662; F:Toll-like receptor 4 binding; IBA:GO_Central.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:2000343; P:positive regulation of chemokine (C-X-C motif) ligand 2 production; IBA:GO_Central.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IBA:GO_Central.
DR GO; GO:0032872; P:regulation of stress-activated MAPK cascade; IBA:GO_Central.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IBA:GO_Central.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017279; Tol-interleuk_rcpt_adapt_Tirap.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR22662; TIRAP; 1.
DR PANTHER; PTHR22662:SF0; TOLL_INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 67..196
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 204 AA; 22150 MW; ECA9446950577383 CRC64;
LQYWFRQALS KKPKVPVSPE STPSDVSQPS SQDSNPPQCL SSVVSPTPPP TNTGTSSSSS
SSGRWSKDYD VCVCHSEQDL VAAQELVSYL EDSPAGLRCF LQLRDATPGG AIVSELCQAL
SNSHCCVLLI TPGFLQDPWC KYQMLQALTQ SPGAEGCTIP LLSGLTRAAY PAELRFMYFV
DGQGPDHGFR QVKQAVMRYL QTLS
//
