ID F6QTV4_HORSE Unreviewed; 193 AA.
AC F6QTV4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=RAB22A, member RAS onco family {ECO:0000313|Ensembl:ENSECAP00000010637.3};
GN Name=RAB22A {ECO:0000313|Ensembl:ENSECAP00000010637.3,
GN ECO:0000313|VGNC:VGNC:22095};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010637.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010637.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010637.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010637.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010637.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004616}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004616}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004616}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270}.
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DR AlphaFoldDB; F6QTV4; -.
DR STRING; 9796.ENSECAP00000010637; -.
DR PaxDb; 9796-ENSECAP00000010637; -.
DR Ensembl; ENSECAT00000013401.4; ENSECAP00000010637.3; ENSECAG00000012914.4.
DR VGNC; VGNC:22095; RAB22A.
DR GeneTree; ENSGT00940000157009; -.
DR HOGENOM; CLU_041217_10_2_1; -.
DR InParanoid; F6QTV4; -.
DR TreeFam; TF331262; -.
DR Proteomes; UP000002281; Chromosome 22.
DR Bgee; ENSECAG00000012914; Expressed in spinal cord and 23 other cell types or tissues.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR47977; RAS-RELATED PROTEIN RAB; 1.
DR PANTHER; PTHR47977:SF13; RAS-RELATED PROTEIN RAB-31 ISOFORM X1; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..193
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040244259"
FT REGION 168..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 193 AA; 21541 MW; 665E06ECC8C327DA CRC64;
MVSSPISLLV YLLLDCELLG GRDCLHVCAL SPWHTVLMPA DLCQWIASPA LVQIRKDISP
TYFYLFRALA PMYYRGSAAA IIVYDITKEE TFSTLKNWVK ELGQHGPPNI VVAIAGNKCD
LVDVREVMER DAKDYADSIH AIFVETSAKN AININELFIE ISRRIPSTDA NPPSGGKGFK
LRRQPSEPRR SCC
//
