ID F6QY89_HORSE Unreviewed; 838 AA.
AC F6QY89;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Cold shock domain containing E1 {ECO:0000313|Ensembl:ENSECAP00000018826.3};
GN Name=CSDE1 {ECO:0000313|Ensembl:ENSECAP00000018826.3,
GN ECO:0000313|VGNC:VGNC:16894};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018826.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000018826.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018826.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000018826.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018826.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005610354.1; XM_005610297.2.
DR RefSeq; XP_005610355.1; XM_005610298.2.
DR RefSeq; XP_005610356.1; XM_005610299.2.
DR AlphaFoldDB; F6QY89; -.
DR Ensembl; ENSECAT00000022763.3; ENSECAP00000018826.3; ENSECAG00000020885.4.
DR GeneID; 100065444; -.
DR CTD; 7812; -.
DR VGNC; VGNC:16894; CSDE1.
DR GeneTree; ENSGT00390000016950; -.
DR OrthoDB; 56539at2759; -.
DR TreeFam; TF324707; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000020885; Expressed in gluteus medius and 23 other cell types or tissues.
DR ExpressionAtlas; F6QY89; baseline.
DR GO; GO:0070937; C:CRD-mediated mRNA stability complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0106002; C:mCRD-mediated mRNA stability complex; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0035613; F:RNA stem-loop binding; IEA:Ensembl.
DR GO; GO:0070934; P:CRD-mediated mRNA stabilization; IEA:Ensembl.
DR GO; GO:0075522; P:IRES-dependent viral translational initiation; IEA:Ensembl.
DR GO; GO:1900152; P:negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IEA:Ensembl.
DR GO; GO:0070966; P:nuclear-transcribed mRNA catabolic process, no-go decay; IEA:Ensembl.
DR GO; GO:2000767; P:positive regulation of cytoplasmic translation; IEA:Ensembl.
DR GO; GO:0034063; P:stress granule assembly; IEA:Ensembl.
DR CDD; cd04458; CSP_CDS; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 6.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR019844; CSD_1.
DR InterPro; IPR002059; CSP_DNA-bd.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR024642; SUZ-C.
DR PANTHER; PTHR12913:SF1; COLD SHOCK DOMAIN-CONTAINING PROTEIN E1; 1.
DR PANTHER; PTHR12913; UNR PROTEIN N-RAS UPSTREAM GENE PROTEIN; 1.
DR Pfam; PF00313; CSD; 5.
DR Pfam; PF12901; SUZ-C; 1.
DR SMART; SM00357; CSP; 5.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 5.
DR PROSITE; PS00352; CSD_1; 4.
DR PROSITE; PS51857; CSD_2; 9.
DR PROSITE; PS51938; SUZ_C; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:F6QY89};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 65..129
FT /note="CSD"
FT /evidence="ECO:0000259|PROSITE:PS51857"
FT DOMAIN 151..218
FT /note="CSD"
FT /evidence="ECO:0000259|PROSITE:PS51857"
FT DOMAIN 225..287
FT /note="CSD"
FT /evidence="ECO:0000259|PROSITE:PS51857"
FT DOMAIN 322..376
FT /note="CSD"
FT /evidence="ECO:0000259|PROSITE:PS51857"
FT DOMAIN 388..452
FT /note="CSD"
FT /evidence="ECO:0000259|PROSITE:PS51857"
FT DOMAIN 482..549
FT /note="CSD"
FT /evidence="ECO:0000259|PROSITE:PS51857"
FT DOMAIN 558..621
FT /note="CSD"
FT /evidence="ECO:0000259|PROSITE:PS51857"
FT DOMAIN 654..712
FT /note="CSD"
FT /evidence="ECO:0000259|PROSITE:PS51857"
FT DOMAIN 713..777
FT /note="CSD"
FT /evidence="ECO:0000259|PROSITE:PS51857"
FT DOMAIN 788..829
FT /note="SUZ-C"
FT /evidence="ECO:0000259|PROSITE:PS51938"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 93182 MW; 8D5C712D7721E3CB CRC64;
MENVFTVSSD PHPPPSLSLP LSSTSSGTKK QKRTPMYQRS MSFDPNLLHN NGHNGYPNGT
SAALRETGVI EKLLTSYGFI QCSERQARLF FHCSQYNGNL QDLKVGDDVE FEVSSDRRTG
KPIAVKLVKI KPEILPEERI NGQVVCAVPH NLESKSPAAP GQSPTGSVCY ERNGEVFYLT
YTPEDVEGNV QLETGDKINF VIDNNKHTGA VSARNIMLLK KKPARCQGVV CAMKEAFGFI
ERGDVVKEIF FHYSEFKGDL ETLQPGDDVE FTIKDRNGKE VATDVRLLPQ GTVIFEDISI
EHFEGTVTKV IPKVPSKNQN DPLPGRIKVD FVIPKELPFG DKDTKSKVTL LEGDHVRFNI
STDRRDKLER ATNIEVLSNT FQFTNEAREM GVIAAMRDGF GFIKCVDRDA RMFFHFSEIL
DGNQLHIADE VEFTVVPDML SAQRNHAIRI KKLPKGTVSF HSHSDHRFMG TVEKEATFSN
PKTTSPNKGK EKEAEDGVIA YDDCGVKLTI AFQAKDVEGS TSPQIGDKVE FSISDKQRPG
QQIATCVRLL GRNSNSKRLL GYVATLKDNF GFIETANHDK EIFFHYSEFS GDVDSLELGD
MVEYSLSKGK GNKVSAEKVN KTHSVNGITE EADPTIYSGK VIRPLRSVDP TQTEYQGMIE
IVEEGDMKGE VYPFGIVGMA NKGDCLQKGE SVKFQLCVLG QNAQTMAYNI TPLRRATVEC
VKDQFGFINY EVGDSKKLFF HVKEVQDGIE LQAGDEVEFS VILNQRTGKC SACNVWRVCE
GPKAVAAPRP DRLVNRLKNI TLDDASAPRL MVLRQPRGPD NSMGFGAERK IRQAGVID
//
