ID F6R0L2_HORSE Unreviewed; 1944 AA.
AC F6R0L2; A0A3Q2I7U9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Anaphase promoting complex subunit 1 {ECO:0000313|Ensembl:ENSECAP00000022855.3};
GN Name=ANAPC1 {ECO:0000313|VGNC:VGNC:15289};
GN Synonyms=LOC111768045 {ECO:0000313|Ensembl:ENSECAP00000022855.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022855.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000022855.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022855.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000022855.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022855.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the APC1 family.
CC {ECO:0000256|ARBA:ARBA00010547}.
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DR RefSeq; XP_001494848.1; XM_001494798.4.
DR RefSeq; XP_005599894.1; XM_005599837.2.
DR RefSeq; XP_014586516.1; XM_014731030.1.
DR STRING; 9796.ENSECAP00000022855; -.
DR PaxDb; 9796-ENSECAP00000022855; -.
DR Ensembl; ENSECAT00000029135.4; ENSECAP00000022855.3; ENSECAG00000007006.5.
DR Ensembl; ENSECAT00000060543.2; ENSECAP00000044181.1; ENSECAG00000039696.3.
DR Ensembl; ENSECAT00000140444.1; ENSECAP00000072543.1; ENSECAG00000036304.3.
DR GeneID; 100051869; -.
DR KEGG; ecb:100051869; -.
DR CTD; 64682; -.
DR VGNC; VGNC:15289; ANAPC1.
DR GeneTree; ENSGT00390000016757; -.
DR HOGENOM; CLU_001202_1_0_1; -.
DR OMA; MQPPDSR; -.
DR OrthoDB; 180933at2759; -.
DR TreeFam; TF105441; -.
DR Proteomes; UP000002281; Chromosome 15.
DR Bgee; ENSECAG00000007006; Expressed in inner cell mass and 23 other cell types or tissues.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR024990; Apc1.
DR InterPro; IPR048971; Apc1_3rd.
DR InterPro; IPR041221; APC1_C.
DR InterPro; IPR046794; Apc1_MidN.
DR InterPro; IPR049255; Apc1_N.
DR InterPro; IPR011989; ARM-like.
DR PANTHER; PTHR12827:SF3; ANAPHASE-PROMOTING COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR12827; MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER; 1.
DR Pfam; PF12859; ANAPC1; 2.
DR Pfam; PF21282; APC1_3rd; 1.
DR Pfam; PF18122; APC1_C; 1.
DR Pfam; PF20518; Apc1_MidN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 81..203
FT /note="Anaphase-promoting complex subunit 1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12859"
FT DOMAIN 589..664
FT /note="Anaphase-promoting complex subunit 1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12859"
FT DOMAIN 666..985
FT /note="Anaphase-promoting complex subunit 1 middle"
FT /evidence="ECO:0000259|Pfam:PF20518"
FT DOMAIN 1617..1702
FT /note="Anaphase-promoting complex subunit 1 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF21282"
FT DOMAIN 1736..1895
FT /note="Anaphase-promoting complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18122"
FT REGION 319..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1944 AA; 216555 MW; F41981945F14AE2C CRC64;
MSNFYEERAT MIAAGDLQEF VPFGRDHCKH HPNALNLQLR QLQPASELWS SDGAAGLVGS
LQEVTIHEKQ KESWQLRKGV SEIGEEVDYD EELYVAGNMV IWSKGSKSQA LAVYKAFTVD
SPVQQALWCD FIISQDKSEK AYSSDEVEKC ICILQSSCIN MHSIEGKDYI ASLPFQVANV
WPTKYGLLFE RSTSSHEVPP GPPREPLPTM FSMLHPLDEI TPLVCKSGSL FGSSRVQYVV
DHAMKIVFLN TDPSIVMTYD TVQSLHSVWA LRRVKPEEEN VVLKFSEQGG TPQNVATSSS
LTAHLRSLSK GDSPVASPFQ NYSSIHSQSR STSSPSLHSR SPSISNMAAL SRAHSPALGV
HSFSGVQRFN LSSHNQSPKR HSISHSPNSN SNGSFFAPET EPIVPELCID HLWTETITNI
REKNSQASKV FITSDLCGQK FLCFLVESQL QLRCVKFQES NDKTQLIFGS VTNIQAKDAA
PVEKIDTMLV LEGSGNLVLY TGVVRVGKVF IPGLPAPSLT MSNTMPRPST PLDSVSTPKP
LSKLLGSLDE VVLLSPVPEL RDSSKLHDCL YNEDCTFQQL GTYIHSIRDP VHNRVTLELS
NGSMVRITIP EIATSELVQT CLQAVKFILP KEIAVQVLVK WYSVHSAPGG PSYHSEWNLF
VICLMNMMGY NTDRLAWTRN FDFEGSLSPV IAPKKARPSE TGSDDDWEYL LNSDYHQNVE
SHLLNRSLCL SPLEVSQMKD EDFSQNLILD SSTLLFTHIP AIFFVLHLVY EELKLNTLMG
EGIRSLVDLL VQLARDLKLE PYVDHYYRDY PTLVRTTGQV CTVDQGQTGF MHHPSFFTSE
PPNIYQWVSS CLRGEGMPPY PYLPGICERS RLVVLSIALY ILGDESSVSE ESSQYLSKIT
IAPQQSQTEQ EENRFSFRHA TSVSSLAERL VVWMTNVGFT LRDLETLPFG IALPIRDAIY
HCREQPASDW PEAVCLLIGR QDLSKQACEG NLPKGKSVLS SDVPSGTETE EEDDGMNDMN
QEVMSLIWSE DLRVQDVRRL LQSAHPVRVN VVQYPELSDH EFIEEKENRL LQLCQRTMAL
PVGRGMFTLF SYHPVPTEPL PIPKLNLTGR APPRNTTVDL NSGNIDVPPN MTSWASFHNG
VAAGLKIAPA SQIDSAWIVY NKPKHAELAN EYAGFLMALG LNGHLTKLAT LNIHDYLTKG
HEMTSIGLLL GVSAAKLGTM DMSITRLLSI HIPALLPPTS TELDVPHNVQ VAAVVGIGLV
YQGTAHRHTA EVLLAEIGRP PGPEMEYCTD RESYSLAAGL ALGMVCLGHG SNLIGMSDLN
VPEQLYQYMV GGHRRFQAGL HREKHKSPSY QIKEGDTINV DVTCPGATLA LAMIYLKTNN
RSIADWLQAP DTMYLLDFVK PEFLLLRTLA RCLILWDDIL PNSKWVDSNV PQIIRENSIS
LSEIELPCSE DLNLETLSQA HVYIIAGACL SLGFRFAGSE NLSAFNCLHK FAKDFMTYLS
APNASVTGPY NLETCLSVVL LSLAMVMAGS GNLKVLQLCR YLHMKTGGEM NYGFHLAHHM
ALGLLFLGGG RYSLSTSNSS IAALLCALYP HFPAHGTDNR YHLQALRHLY VLAAEPRLLV
PVDVDTNMPC YALLEVTYKG TQWYEQTKEE LMAPTLLPEL HLLKQIKVKG PRYWELLIDL
SKGTQHLKSI LSKDGVLYVK LRAGQLSYKE DPMGWQSLLA QTVANRNSEA RAFKPETISA
FTSDPALLSF AEYFCKPTVN MGQKQEILDL FSSVLYECVT QETPEMLPAY IAMDQAIRRL
GRREMSETSE LWQIKLVLEF FSSRSHQERL QNHPKRGLFM NSEFLPVVKC TIDNTLDQWL
QAGGDACVHA YLSGQPSEES QLSMLACFLV YYSVPAPRHL PSIGLEGSTS FAELLFRFKQ
LRMPVRALLR LAPLLLGNPQ PMVM
//
