ID F6RHB3_HORSE Unreviewed; 4593 AA.
AC F6RHB3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Dynein cytoplasmic 1 heavy chain 1 {ECO:0000313|Ensembl:ENSECAP00000022808.3};
GN Name=DYNC1H1 {ECO:0000313|Ensembl:ENSECAP00000022808.3,
GN ECO:0000313|VGNC:VGNC:17366};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022808.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000022808.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022808.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000022808.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022808.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 9796.ENSECAP00000022808; -.
DR PaxDb; 9796-ENSECAP00000022808; -.
DR Ensembl; ENSECAT00000028966.4; ENSECAP00000022808.3; ENSECAG00000015929.5.
DR VGNC; VGNC:17366; DYNC1H1.
DR GeneTree; ENSGT00940000156103; -.
DR InParanoid; F6RHB3; -.
DR OMA; NERQMTR; -.
DR OrthoDB; 312195at2759; -.
DR TreeFam; TF101165; -.
DR Proteomes; UP000002281; Chromosome 24.
DR Bgee; ENSECAG00000015929; Expressed in cerebellum and 23 other cell types or tissues.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR GO; GO:0008090; P:retrograde axonal transport; IBA:GO_Central.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F6RHB3};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1848..1992
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2163..2314
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2534..2684
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2876..3042
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 2337..2357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1120..1147
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3152..3200
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3349..3446
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2337..2355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4593 AA; 527058 MW; EF9C194FF76DC58B CRC64;
MRKFLSDPQV HTVLVERSTL KEDVGDEGEE EKEFISYNIN IDIHYGVKSN SLAFIKRTPV
IDADKPVSSQ LRVLTLSEDS PYETLHSFIS NAVAPFFKSY IRESGKADRD GDKMAPSVEK
KIAELEMGLL HLQQNIEIPE ISLPIHPIIT NVAKQCYERG EKPKVTDFGD KVEDPTFLNQ
LQSGVNRWIR EIQKVTKLDR DPASGTALQE ISFWLNLERA LYRIQEKRES PEVLLTLDIL
KHGKRFHATV SFDTDTGLKQ ALETVNDYNP LMKDFPLNDL LSATELDKIR QALVAIFTHL
RKIRNTKYPI QRALRLVEAI SRDLSSQLLK VLGTRKLMHV AYEEFEKVMV ACFEVFQTWD
DEYEKLQVLL RDIVKRKREE NLKMVWRINP AHRKLQARLD QMRKFRRQHE QLRAVIVRVL
RPQVTAVAQQ NQGEVPEPQD MKVAEVLFDA ADANAIEEVN LAYENVKEVD GLDVSKEGTE
AWEAAMKRYD ERIDRVETRI TARLRDQLGT AKNANEMFRI FSRFNALFVR PHIRGAIREY
QTQLIQRVKD DIESLHDKFK VQYPQSQACK MSHVRDLPPV SGSIIWAKQI DRQLTAYMKR
VEDVLGKGWE NHVEGQKLKQ DGDSFRMKLN TQEIFDDWAR KVQQRNLGVS GRIFTIESTR
VRGRSGNVLK LKVNFLPEII TLSKEVRNLK WLGFRVPLAI VNKAHQANQL YPFAISLIES
VRTYERTCEK VEERNTISLL VAGLKKEVQA LIAEGIALVW ESYKLDPYVQ RLAETVFNFQ
EKVDDLLIIE EKIDLEVRSL ETCMYDHKTF SEILNRVQKA VDDLNLHSYS NLPIWVHKLD
MEIERILGVR LQAGLRAWTQ VLLGQAEDKA EVDMDTDAPQ VSHKPGGEPK IKNVVHELRI
TNQVIYLNPP IEECRYKLYQ EMFAWKMVVL SLPRIQSQRY QVGVHYELTE EEKFYRNALT
RMPDGPVALE ESYSAVMGIV TEVEQYVKVW LQYQCLWDMQ AENIYNRLGE DLNKWQALLV
QIRKARGTFD NAETKKEFGP VVIDYGKVSS AVLLKGVKVQ SKVNLKYDSW HKEVLSKFGQ
MLGSNMTEFH SQISKSRQEL EQHSVDTAST SDAVTFITYV QSLKRKIKQF EKQVELYRNG
QRLLEKQRFQ FPPSWLYIDN IEGEWGAFND IMRRKDSAIQ QQVANLQMKI VQEDRAVESR
TTDLLTDWEK TKPVTGNLRP EEALQALTIY EGKFGRLKDD REKCAKAKEA LELTDTGLLS
GSEERVQVAL EELQDLKGVW SELSKVWEQI DQMKEQPWVS VQPRKLRQNL DGLLNQLKNF
PARLRQYASY EFVQRLLKGY LKINMLVIEL KSEALKDRHW KQLMKRLHVN WVVSELTLGQ
IWDVDLQKNE AIVKDVLLVA QGEMALEEFL KQIREVWNTY ELDLVNYQNK CRLIRGWDDL
FNKVKEHINS VSAMKLSPYY KVFEEDALSW EDKLNRIMAL FDVWIDVQRR WVYLEGIFTG
SADIKHLLPV ETQRFQSIST EFLALMKKVS KSPLVMDVLN IQGVQRSLER LADLLGKIQK
ALGEYLERER SSFPRFYFVG DEDLLEIIGN SKNVAKLQKH FKKMFAGVSS IILNEDNSVV
LGISSREGEE VMFKTPVSIT EHPKINEWLT LVEKEMRVTL AKLLAESVTE VEIFGKATSI
DPNTYITWID KYQAQLVVLS AQIAWSENVE TALSSIGGSG DAAPLHSVLS NVEVTLNVLA
DSVLMEQPPL RRRKLEHLIT ELVHQRDVTR SLIKSKIDNA KSFEWLSQMR FYFDPKQTDV
LQQLSIQMAN AKFNYGFEYL GVQDKLVQTP LTDRCYLTMT QALEARLGGS PFGPAGTGKT
ESVKALGHQL GRFVLVFNCD ETFDFQAMGR IFVGLCQVGA WGCFDEFNRL EERMLSAVSQ
QVQCIQEALR EHSNPNYDKT SAPITCELLN KQVKVSPDMA IFITMNPGYA GRSNLPDNLK
KLFRSLAMTK PDRQLIAQVM LYSQGFRTAE VLANKIVPFF KLCDEQLSSQ SHYDFGLRAL
KSVLVSAGNV KRERIQKIKR EKEERGEAVD EGEIAENLPE QEILIQSVCE TMVPKLVAED
IPLLFSLLSD VFPGVQYHRG EMTALREELK KVCQEMYLTY GDGEEVGGTW VEKVLQLYQI
TQINHGLMMV GPSGSGKSMA WRVLLKALER LEGVEGVAHI IDPKAISKDH LYGTLDPNTR
EWTDGLFTHV LRKIIDNVRG ELQKRQWIVF DGDVDPEWVE NLNSVLDDNK LLTLPNGERL
SLPPNVRIMF EVQDLKYATL ATVSRCGMVW FSEDVLSTDM IFNNFLARLR SIPLDEGEDE
AQRRRKGKED EGEEAASPML QIQRDAATIM QPYFTSNGLV TKALEHAFKL EHIMDLTRLR
CLGSLFSMLH QACRNVAQYN ANHPDFPMQI EQLERYIQRY LVYAILWSLS GDSRLKMRAE
LGEYIRRITT VPLPAAPNIP IIDYEVSISG EWSPWQAKVP QIEVETHKVA APDVVVPTLD
TVRHEALLYT WLAEHKPLVL CGPPGSGKTM TLFSALRALP DMEVVGLNFS SATTPELLLK
TFDHYCEYRR TPNGVVLAPV QLGKWLVLFC DEINLPDMDK YGTQRVISFI RQMVEHGGFY
RTSDQTWVKL ERIQFVGACN PPTDPGRKPL SHRFLRHVPV VYVDYPGPAS LTQIYGTFNR
AMLRLIPSLR TYAEPLTAAM VEFYTMSQER FTQDTQPHYI YSPREMTRWV RGIFEALRPL
ETLPVEGLIR IWAHEALRLF QDRLVEDEER RWTDENIDMV ALKHFPNIDK EKAMSRPILY
SNWLSKDYIP VDQEELRDYV KARLKVFYEE ELDVPLVLFN EVLDHVLRID RIFRQPQGHL
LLIGVSGAGK TTLSRFVAWM NGLSVYQIKV HRKYTGEDFD EDLRTVLRRS GCKNEKIAFI
MDESNVLDSG FLERMNTLLA NGEVPGLFEG DEYATLMTQC KEGAQKEGLM LDSHEELYKW
FTSQVIRNLH VVFTMNPSSE GLKDRAATSP ALFNRCVLNW FGDWSTEALY QVGKEFTSKM
DLEKPNYIVP DYMPVVYDKL PQPPSHREAI VNSCVFVHQT LHQANARLAK RGGRTMAITP
RHYLDFINHY ANLFHEKRSE LEEQQMHLNV GLRKIKETVD QVEELRRDLR IKSQELEVKN
AAANDKLKKM VKDQQEAEKK KVMSQEIQEQ LHKQQEVIAD KQMSVKEDLD KVEPAVIEAQ
NAVKSIKKQH LVEVRSMANP PAAVKLALES ICLLLGESTT DWKQIRSVIM RENFIPTIVN
FSAEEISDAI REKMKKNYMS NPSYNYEIVN RASLACGPMV KWAIAQLNYA DMLKRVEPLR
NELQKLEDDA KDNQQKANEV EQMIRDLEAS IARYKEEYAV LISEAQAIKA DLAAVEAKVN
RSTALLKSLS AERERWEKTS ETFKNQMSTI AGDCLLSAAF IAYAGYFDQQ MRQNLFTTWS
HHLQQANIQF RTDIARTEYL SNADERLRWQ ASSLPADDLC TENAIMLKRF NRYPLIIDPS
GQATEFIMNE YKDRKITRTS FLDDAFRKNL ESALRFGNPL LVQDVESYDP VLNPVLNREV
RRTGGRVLIT LGDQDIDLSP SFVIFLSTRD PTVEFPPDLC SRVTFVNFTV TRSSLQSQCL
NEVLKAERPD VDEKRSDLLK LQGEFQLRLR QLEKSLLQAL NEVKGRILDD DTIITTLENL
KREAAEVTRK VEETDIVMQE VETVSQQYLP LSTACSSIYF TMESLKQIHF LYQYSLQFFL
DIYHNVLYEN PNLKGITDHT QRLSIITKDL FQVAFNRVAR GMLHQDHITF AMLLARIKLK
GTVGEPTYDA EFQHFLRGKE IVLSAGSTPK IQGLTVEQAE AVVRLSCLPA FKDLIAKVQA
DEQFGIWLDS SSPEQTVPYL WSEDIPATPI GQAIHRLLLI QAFRPDRLLA MAHMFVSTNL
GESFMSIMEQ PLDLTHIVDT EVKPNTPVLM CSVPGYDASG HVEDLAAEQN TQITSIAIGS
AEGFNQADKA INTAVKSGRW VMLKNVHLAP GWLMQLEKKL HSLQPHACFR LFLTMEINPK
VPVNLLRAGR IFVFEPPPGV KANMLRTFSS IPVSRICKSP NERARLYFLL AWFHAIIQER
LRYAPLGWSK KYEFGESDLR SACDTVDTWL DDTAKGRQNI SPDKIPWSAL KTLMAQSIYG
GRVDNEFDQR LLNTFLERLF TTKSFDSEFK LACKVDGHKD IQMPDGIRRE EFVQWVELLP
DTQTPSWLGL PNNAERVLLT TQGVDMISKM LKMQMLEDED DLAYAEAEKK TRTDSTSDGR
PAWMRTLHTT ASNWLHLIPP TLSHLKRTVE NIKDPLFRFF EREVKMGAKL LQDVRQDLAD
VVQVCEGKKK QTNYLRTLIN ELVKGILPRS WSHYTVPAGM TVIQWVSDFS ERIKQLQNIS
LAAASGGAKE LKNIHVCLGG LFVPEAYITA TRQYVAQANS WSLEELCLEV NVTTSQSATL
DACSFGVTGL KLQGATCNNN KLSLSNAIST VLPLTQLRWV KQTNAEKKAN VVTLPVYLNF
TRADLIFTVD FEIATKEDPR SFYERGVAVL CTE
//
