ID F6RJS3_HORSE Unreviewed; 361 AA.
AC F6RJS3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=G protein-coupled receptor 68 {ECO:0000313|Ensembl:ENSECAP00000003420.3};
GN Name=GPR68 {ECO:0000313|Ensembl:ENSECAP00000003420.3,
GN ECO:0000313|VGNC:VGNC:18546};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003420.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000003420.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003420.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000003420.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003420.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_005605458.1; XM_005605401.2.
DR RefSeq; XP_005605459.1; XM_005605402.2.
DR RefSeq; XP_014591244.1; XM_014735758.1.
DR AlphaFoldDB; F6RJS3; -.
DR STRING; 9796.ENSECAP00000003420; -.
DR PaxDb; 9796-ENSECAP00000003420; -.
DR Ensembl; ENSECAT00000004904.4; ENSECAP00000003420.3; ENSECAG00000004969.4.
DR Ensembl; ENSECAT00000079690.1; ENSECAP00000067514.1; ENSECAG00000004969.4.
DR Ensembl; ENSECAT00000093418.1; ENSECAP00000070602.1; ENSECAG00000004969.4.
DR Ensembl; ENSECAT00000096989.1; ENSECAP00000063121.1; ENSECAG00000004969.4.
DR Ensembl; ENSECAT00000107681.1; ENSECAP00000072936.1; ENSECAG00000004969.4.
DR Ensembl; ENSECAT00000109702.1; ENSECAP00000067437.1; ENSECAG00000004969.4.
DR Ensembl; ENSECAT00000112551.1; ENSECAP00000079231.1; ENSECAG00000004969.4.
DR Ensembl; ENSECAT00000134053.1; ENSECAP00000076964.1; ENSECAG00000004969.4.
DR Ensembl; ENSECAT00000144290.1; ENSECAP00000070677.1; ENSECAG00000004969.4.
DR Ensembl; ENSECAT00000144323.1; ENSECAP00000084463.1; ENSECAG00000004969.4.
DR GeneID; 100053071; -.
DR KEGG; ecb:100053071; -.
DR VGNC; VGNC:18546; GPR68.
DR GeneTree; ENSGT00950000183136; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; F6RJS3; -.
DR OMA; TCCFVFT; -.
DR TreeFam; TF331803; -.
DR Proteomes; UP000002281; Chromosome 24.
DR Bgee; ENSECAG00000004969; Expressed in leukocyte and 20 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0071467; P:cellular response to pH; IBA:GO_Central.
DR CDD; cd15367; 7tmA_GPR68_OGR1; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR005389; OGR1_rcpt.
DR PANTHER; PTHR24234; LYSOPHOSPHATIDIC ACID RECEPTOR 5/SPHINGOSYLPHOSPHORYLCHOLINE RECEPTOR; 1.
DR PANTHER; PTHR24234:SF5; OVARIAN CANCER G-PROTEIN COUPLED RECEPTOR 1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01564; OGR1RECEPTOR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..286
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 361 AA; 40752 MW; 73A994CD00185BF0 CRC64;
MGNITADNSS LSCTIDHTIH QTLAPVVYVT VLVVGFPANC LSLYFGYLQI KARNELGVYL
CNLTVADLFY ICSLPFWLQY VLQHDHWSHG DLSCQVCGIL LYENIYISVG FLCCISIDRY
LAVAHPFRFH QFRTLKAAVS VSVVIWVKEL LTSVYFLMHK EVVEDENQHR VCFEHYPLEA
WQRSINYYRF LVGFLFPICL LLASYQGILR AVRRSHGTQK SRKDQIQRLV LSTVVIFLAC
FLPYHVLLLV RSLWESSCEF ATGIFNAYHF SLLLTSFNCV ADPVLYCFVS ETTHRDLARL
RGACLAFLTC SRTSRAREAY PLGAPEASGK SEEPELLMKL HSAFQTPNSS GVGGSPTGGL
A
//
