ID F6RKG2_XENTR Unreviewed; 239 AA.
AC F6RKG2; Q5FVY6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Tissue factor pathway inhibitor {ECO:0000256|PIRNR:PIRNR001620};
GN Name=tfpi2 {ECO:0000313|Ensembl:ENSXETP00000030406};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000030406};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000030406}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000030406};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000030406}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR001620}.
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DR AlphaFoldDB; F6RKG2; -.
DR DNASU; 548483; -.
DR Ensembl; ENSXETT00000030406; ENSXETP00000030406; ENSXETG00000013900.
DR AGR; Xenbase:XB-GENE-1002090; -.
DR Xenbase; XB-GENE-1002090; tfpi2.
DR eggNOG; KOG4295; Eukaryota.
DR HOGENOM; CLU_058441_1_0_1; -.
DR InParanoid; F6RKG2; -.
DR OrthoDB; 3558236at2759; -.
DR TreeFam; TF315349; -.
DR Bgee; ENSXETG00000013900; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-UniRule.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:1903706; P:regulation of hemopoiesis; IEA:Ensembl.
DR GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR CDD; cd22615; Kunitz_TFPI1_TFPI2_3-like; 1.
DR CDD; cd22616; Kunitz_TFPI2_1-like; 1.
DR CDD; cd22617; Kunitz_TFPI2_2-like; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 3.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR008296; TFPI-like.
DR PANTHER; PTHR10083; KUNITZ-TYPE PROTEASE INHIBITOR-RELATED; 1.
DR PANTHER; PTHR10083:SF352; TISSUE FACTOR PATHWAY INHIBITOR 2; 1.
DR Pfam; PF00014; Kunitz_BPTI; 3.
DR PIRSF; PIRSF001620; TFPI; 2.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 3.
DR SUPFAM; SSF57362; BPTI-like; 3.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 2.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 3.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084,
KW ECO:0000256|PIRNR:PIRNR001620};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696, ECO:0000256|PIRNR:PIRNR001620};
KW Protease inhibitor {ECO:0000256|PIRNR:PIRNR001620};
KW Serine protease inhibitor {ECO:0000256|PIRNR:PIRNR001620};
KW Signal {ECO:0000256|PIRNR:PIRNR001620}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|PIRNR:PIRNR001620"
FT CHAIN 20..239
FT /note="Tissue factor pathway inhibitor"
FT /evidence="ECO:0000256|PIRNR:PIRNR001620"
FT /id="PRO_5031673656"
FT DOMAIN 29..79
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 89..139
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 149..199
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 239 AA; 27180 MW; BAA0AC01C155D918 CRC64;
MHASLQALMA ASLLIQVFGS PMQGNTTVCL LPPDEGPCKA LIPHYYYDRY TQTCQEFLYG
GCDGNSNKFL SMEDCEKFCW KIKKVPKACR MDPDEGPCRG FLKRYAYNMQ TMKCEQFYYG
GCYGNDNNFK DKASCMDFCS PRRDAPSFCY SPKDEGSCSA SVTRYYFNIE SKACEEFVYT
GCGGNSNNFV KMEDCDSVCK KGTCYFNVVK GQETEIASAY RGYSHENRKD QNSLLYQLH
//
