ID F6RN59_ORNAN Unreviewed; 955 AA.
AC F6RN59;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL1A {ECO:0000313|Ensembl:ENSOANP00000028194.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000028194.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000028194.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000028194.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000028194.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000028194.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR AlphaFoldDB; F6RN59; -.
DR STRING; 9258.ENSOANP00000028194; -.
DR Ensembl; ENSOANT00000031992.3; ENSOANP00000028194.2; ENSOANG00000022107.3.
DR eggNOG; KOG2209; Eukaryota.
DR GeneTree; ENSGT00940000155295; -.
DR HOGENOM; CLU_935512_0_0_1; -.
DR Proteomes; UP000002279; Chromosome 7.
DR Bgee; ENSOANG00000022107; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13285; PH_ORP1; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF53; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT REPEAT 47..79
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 80..112
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 175..207
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 235..334
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 498..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 422..461
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 800..814
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 955 AA; 107701 MW; 3284CF4EA97B3A02 CRC64;
MSTEAEQQLL HDARNGKTEE VRQLLETVER KEVVANINCK GRSKSNLGWT PLHLACYFGH
GQVVQDLLKA GAEVNVLNDM GDTPLHRAAF TGRKELVMLL LQYNADTAVV NGSGQTAKDV
THDKEIRNML EAVEKTQQRK LEELLLAAAR EGNTAELTVL LNSATPPDVN CSDPLGNTPL
HCAAYRAHKQ CALKLLKSGA DPGRRNQNDQ RPMDLAQGAE MKHMLGGSKV FYKLLRRYEG
PLWKSSRFFG WRLFWIVLEH GVLSWYRKQA DAGSNAHRQG CKHLTQALCT VKSTDSCLFF
VKCFDDSIHC FRVPKNNLQQ SRESWIEAIE EHSAYSTHYC SQDQLSDEEE DQDGISAGDL
KESLKNAQAC QQRLDEEIST FLKMIKECDT TKEILPSFLQ KVEVVSEASR ETCAALSDCL
NLFTKQEEVR NLKLEHEQEK NKILSEALET LATEHHELEQ SLVKGSPPLS ILSEEEFYDA
LSDSASELSL SGLEAVTTHS LEEEAESGSP PTAGMSDGKD SGGGGGGGGS LANGIKKHRT
SLPSPMFSRN DFSIWSILRK CIGMELSKIT MPVIFNEPLS FLQRLTEYME HTYLIHKASG
FSDTVERMQC VATFAVSAVA SQWERTGKPF NPLLGETYEL IRDDLGFRLI SEQVSHHPPV
SAFHAEGLNN DFVFHGSIYP KLKFWGKSVE AEPKGTITLE LLEHNEAYTW TNPTCCVHNI
IVGKLWIEQY GTVEITNHKT GEKCVLNFKP CGLFGKELHK VEGYIQDKSK KKLRVLYGKW
TECLYSVDPA TYDAYKKNDK KNTEEKKTSK QVSGSEEPDE MPLPDSEGVQ VIPGSVLLWR
IAPRPPNSAQ MYNFTSFAMV LNEVDKEMES VIPKTDCRLR PDIRAMENGE IDQASEEKKR
LEEKQRAARK NRSKTEEDWK TRWFHQGPNP YSGAQDWLFS GNYWDRNYFN LPDIY
//
