ID F6S3W4_CHICK Unreviewed; 425 AA.
AC F6S3W4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Bone morphotic protein 10 {ECO:0000313|Ensembl:ENSGALP00010028872.1};
GN Name=BMP10 {ECO:0000313|Ensembl:ENSGALP00010028872.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010028872.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010028872.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010028872.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; NP_001264975.1; NM_001278046.1.
DR AlphaFoldDB; F6S3W4; -.
DR SMR; F6S3W4; -.
DR STRING; 9031.ENSGALP00000000168; -.
DR PaxDb; 9031-ENSGALP00000000168; -.
DR Ensembl; ENSGALT00010048840.1; ENSGALP00010028872.1; ENSGALG00010020231.1.
DR GeneID; 395177; -.
DR KEGG; gga:395177; -.
DR CTD; 27302; -.
DR VEuPathDB; HostDB:geneid_395177; -.
DR GeneTree; ENSGT00940000156279; -.
DR InParanoid; F6S3W4; -.
DR OMA; SAQNKHD; -.
DR OrthoDB; 2912454at2759; -.
DR Reactome; R-GGA-201451; Signaling by BMP.
DR Reactome; R-GGA-2129379; Molecules associated with elastic fibres.
DR Proteomes; UP000000539; Chromosome 22.
DR Bgee; ENSGALG00000000120; Expressed in liver and 1 other cell type or tissue.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:Ensembl.
DR GO; GO:0033612; F:receptor serine/threonine kinase binding; IEA:Ensembl.
DR GO; GO:0031433; F:telethonin binding; IEA:Ensembl.
DR GO; GO:0032924; P:activin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007512; P:adult heart development; IEA:Ensembl.
DR GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0060347; P:heart trabecula formation; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0010596; P:negative regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0010613; P:positive regulation of cardiac muscle hypertrophy; IEA:Ensembl.
DR GO; GO:0061036; P:positive regulation of cartilage development; IEA:Ensembl.
DR GO; GO:2000138; P:positive regulation of cell proliferation involved in heart morphogenesis; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0060298; P:positive regulation of sarcomere organization; IEA:Ensembl.
DR GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; IEA:Ensembl.
DR GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:Ensembl.
DR GO; GO:1903242; P:regulation of cardiac muscle hypertrophy in response to stress; IEA:Ensembl.
DR GO; GO:0055015; P:ventricular cardiac muscle cell development; IEA:Ensembl.
DR GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR CDD; cd19401; TGF_beta_BMP10; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF39; BONE MORPHOGENETIC PROTEIN 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 314..425
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 425 AA; 48467 MW; 672047225618F561 CRC64;
MDSIVLQLWA GLCLLVHLAT CSPILSLEHS SLEEGEPLFD EFLSEQDGVD FNTLLQNMKN
EFLKTLNLSD IPLHESAKVD PPEYMLELYN KFATDRTSMP SANIIRSFKN EDLASHPVGV
IGVRKYPLLF NVSIPHHEEI TMAELRLYTL VERDQMLYEG LDRKVTIFEV LENDHMGVGE
ERKIVALASR QIYGTSSEWE SFEVTEAIRR WRRAGLTTHR LEVHIESREG EEQNGEGKLD
IDINSEAKHV PLLIVFSDDQ SNDQKEEKQE LNEMIDHEQL LDLENLEVGN FHGHPGEEAL
LQMRSNIIYD STARIRRNAK GNYCKKTPLY IDFKEIGWDS WIIAPAGYEA YECHGVCAYP
LTEHVTPTKH AIVQTLVHLK NPQKASKACC VPTKLDPISI LYMDAGVVTY KFKYEGMVVS
ECGCR
//
