ID F6SMQ3_CIOIN Unreviewed; 2014 AA.
AC F6SMQ3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000010385.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000010385.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; EAAA01000007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EAAA01000008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EAAA01000009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCINT00000010385.3; ENSCINP00000010385.3; ENSCING00000005040.3.
DR GeneTree; ENSGT00950000183158; -.
DR HOGENOM; CLU_000233_0_0_1; -.
DR InParanoid; F6SMQ3; -.
DR OMA; DKCTKCD; -.
DR TreeFam; TF316849; -.
DR Proteomes; UP000008144; Chromosome 1.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 37.
DR Gene3D; 2.10.25.10; Laminin; 48.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR PANTHER; PTHR24039:SF28; FIBULIN-1; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF12947; EGF_3; 38.
DR Pfam; PF07645; EGF_CA; 9.
DR SMART; SM00181; EGF; 44.
DR SMART; SM00179; EGF_CA; 48.
DR SUPFAM; SSF57196; EGF/Laminin; 8.
DR SUPFAM; SSF57184; Growth factor receptor domain; 13.
DR PROSITE; PS00010; ASX_HYDROXYL; 40.
DR PROSITE; PS01186; EGF_2; 43.
DR PROSITE; PS50026; EGF_3; 42.
DR PROSITE; PS01187; EGF_CA; 16.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2..42
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 43..83
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 84..118
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 136..176
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 177..217
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 218..258
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 259..299
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 300..340
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 341..381
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 382..422
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 455..495
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 496..530
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 531..571
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 572..612
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 613..653
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 654..694
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 729..769
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 770..810
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 811..851
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 852..892
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 893..933
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 963..1003
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1004..1044
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1045..1085
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1086..1126
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1127..1167
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1168..1207
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1208..1248
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1249..1290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1291..1331
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1332..1369
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1370..1410
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1474..1514
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1515..1554
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1592..1632
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1633..1669
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1736..1776
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1777..1817
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1818..1858
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1900..1940
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1941..1981
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1982..2014
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 1336..1346
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2014 AA; 205260 MW; DDEC834989154491 CRC64;
IDTNECALGT HNCHANATCT NTNGSFTCTC NIGFSGDGVN CTDIDECTLG THNCHANATC
TNTTGSFTCI CNTGFSGDGV SCTDIDECTF GNANCTNTNG SFTCACNTGF TGDGVSCTDI
SVCKTGFTGD GVSCTDINEC TLNTDNCDTN ATCTNTNGSF TCTCNTGFTG DGVNCTDINE
CTLGTHNCHA NANCTNTTGS FTCTCNTGFT GDGVSCTDID ECTLGTHNCH ANANCTDTVG
SFTCACKTGF FGDGVSCADI DECTLGTHNC DTNATCTNTN GSFTCTCNTG FTGDGVNCTD
INECTLGTHN CHANANCTNT TGSFTCTCNT GFTGDGVSCT DIDECTLGTH NCHANANCTD
TVGSFTCACK TGFFGDGVSC TDIDECTLGT HNCHANANCS NTNGSFTCAC KTGFTGDGVT
CTDIDECTLV HTTVMQIFTC ACKTGFFGDG VSCTDIDECT LGTHNCHANA TCSNTTGSFT
CACNTGFTGD GVSCTDIDEC TLANANCTNT NGSFTCACKT GFTGDGVSCT DIDECTLGTH
NCHANATCTN TTGSFTCICN TGFSGDGVSC TDIDEDALGT HNCHTNATCI NTTGSFTCTC
NSGFTGDGVS CTDIDECTLG THNCHTNATC TNTTGSFTCI CNTGFSGDGV SCTDIDECAL
GTHSCHANAT CTNTTGSFTC TCNTGFTGDG VLCTDIDECK VGTHNCHVNA TCTNTTGSFT
SGDGVSCTDI DECTLGTHNC NTNATCSNTI GSFTCACKTG FTGDGVSCTD IDECALGTHN
CHANATCSNT IGSFTCACNT GFTGDGVSCT DIDECALGTH NCHANANCAN TIGSFTCACK
TGFTGDGVSC TDIDECTLGT HNCHANANCT NTIGSFTCAC KTGFTGDGVS CTDIDECALG
THNCHANATC SNTIGSFTCA CKTGFTGDGV SCTDIDECAL GTHNCHANAT CSNTICDGVS
CTDIDECALG THNCHANANC ANTIGSFTCA CKTGFTGDGV SCTDIDECAL GTHNCHANAN
CTNTIGSFTC ACKTGFTGDG VSCTDIDECA LGTHNCHANA NCTNTNGSFT CACKTGFTGD
GVSCTDIDEC ALGTHNCHAN ANCMNTNGSF TCACKTGFTG DGVNCTDIDE CALGTHNCHA
NAKCSNTVGS FTCACKTGFT GDGVTCTDID ECALGTHNCH ANANFNTNGS FTCACKTGFT
GDGVKCTDID ECALGTHNCH ANANCMNTIG SFTCSCKTGF TGDGVTCTDI DECALGTHNC
HANANCMNTI GSFTCSCKTG FTGDGVNNCT DIDECALGTH NCHANAACTN TIGSFTCACK
TGFTGDGVTC TDIDECALEL PCKCNCTNTI GSFTCSCKTG FTGDGVSCTD IDECTLGTHN
CHANANCTNT IGSFTCACKT GFTGDGVSCT DIDECALGTH NCHANANCIN TIILMNVHWV
HTTAMQMLIV PTQMGSFTCA CKTGFTGDGV SCTDIDECAL GTHNCHANAN CINTNGSFTC
ACKTGFTGDG VTCTDIDECA LGTHNCHANA TCNTIGSFTC VCKTGFTGDG VSCTDIDECA
LGTHNCHVSN TIGSFTCCCN TGFTGDGVSC TDIDECALGT HNCHANAACS NTIGSFTCAC
NTGFTGDGVS CTDIDECALV PCKCTCSNTI GSFTCACKTG FTGDGVSCTD IDECALGTHN
CHANATCSNT IGSFTCSAIL GLLVMVYHAQ ILMNVHWVHT TVIKTGFTGD GVSCADIDEC
TLGTHNCHAN ANCTNTIGSF TCSCKTGFTG DGVSCTDIDE CALGTHNCHA NANCTNTIGS
FTCFCKTGFT GDGVSCTDID ECALGTHNCH ANANCANTIG SFTCACKTGF TGDGVSCTDI
DECALGTHNC HANANCTNTI GSFTCVAILG LLVMVYNCTD IDECALGTHN CHANANCTNT
IGSFTCVCKT GFTGDGVSCA DIDECALGTH NCHANANCTN TIGSFTCACK TGFTGDGVSC
TDIDECTLGT HNCHANAACT NTDGNFECSC FNGF
//
