ID F6SN87_HORSE Unreviewed; 2048 AA.
AC F6SN87;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 {ECO:0000313|Ensembl:ENSECAP00000010758.4};
GN Name=TANC2 {ECO:0000313|Ensembl:ENSECAP00000010758.4,
GN ECO:0000313|VGNC:VGNC:23865};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010758.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010758.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010758.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010758.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010758.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TANC family.
CC {ECO:0000256|ARBA:ARBA00038259}.
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DR Ensembl; ENSECAT00000013543.4; ENSECAP00000010758.4; ENSECAG00000012669.4.
DR VGNC; VGNC:23865; TANC2.
DR GeneTree; ENSGT00940000156447; -.
DR HOGENOM; CLU_001464_0_1_1; -.
DR TreeFam; TF323159; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000012669; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; F6SN87; baseline.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR24166:SF21; PROTEIN TANC2; 1.
DR PANTHER; PTHR24166; ROLLING PEBBLES, ISOFORM B; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF13181; TPR_8; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50005; TPR; 3.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 974..1006
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1090..1122
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1123..1155
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1156..1188
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1189..1221
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1222..1254
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1301..1334
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1348..1381
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1382..1415
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 31..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1432..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1492..1644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1841..1862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1880..1901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2026..2048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1432..1451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1492..1570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1582..1598
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1608..1634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1881..1900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2048 AA; 226371 MW; 66528573BCC5EA22 CRC64;
MQHKSSCEMC QFCEYLNNTT MFRNSLKMLL TGGKSSRKNR SSDGGSEEPP DRRQSSVDSR
QSRSGQGGIS TESDCAFEPD YAVPPLPVSE GMQHIRIMEG MSRSLPSSPL LTHQSISVRL
QPVKKLTGDA EQELGPPPSV DEAANTLMTR LGFLLGEKVT EVQPGDQYNM EVQDENQTSA
ITQRISPCST LTSSTASPPA SSPCSTLPPV STNATAKDCS YGAVTSPTST LESRDSGIIA
TLTSYSENVE RTKYVGESSK ELGSGGNLKP WQSQKSSMDS CLYRVDENMT ASTYSLNKIP
DRNLETVLSQ SVQSIPLYLM PRPNSVAATS SAHLEDLAYL DEQRHTPLRT SLRMPRQSMG
GARAQQDLRV RFAPYRPPDI SLKPLLFEVP SITTESVFVG RDWVFHEIDA QLQSSNASVN
QGVVIVGNIG FGKTAIISRL VALSCHGTRM RQIASDSPHA SPKHVDANRE LPLTQPPSAH
SSITSGSCPG TPEMRRRQEE AMRRLASQVV AYHYCQADNA YTCLVPEFVH NVAALLCRSP
QLAAYREQLL REPHLQSMLS LRSCVQDPMA SFRRGVLEPL ENLHKERKIP DEDFIILIDG
LNEAEFHKPD YGDTIVSFLS KMIGKFPSWL KLIVTVRTSL QEITKLLPFH RIFLDRLEEN
EAIDQDLQAY ILHRIHSSSE IQNNISLNGK MDNTTFGKLS SHLKTLSQGS YLYLKLTFDL
IEKGYLVLKS SSYKVVPVSL SEVYLLQCNM KFPTQSSFDR VMPLLNVAVA SLHPLTDEHI
FQAINAGSIE GTLEWEDFQQ RMENLSMFLI KRRDMTRMFV HPSFREWLIW REEGEKTKFL
CDPRSGHTLL AFWFSRQEGK LNRQQTIELG HHILKAHIFK GLSKKVGVSS SILQGLWISY
STEGLSMALA SLRNLYTPNI KVSRLLILGG ANINYRTEVL NNAPILCVQS HLGYTEMVAL
LLEFGANVDA SSESGLTPLG YAAAAGYLSI VVLLCKKRAK VDHLDKNGQC ALVHAALRGH
LEVVKFLIQC DWTMAGQQQG VFKKSHAIQQ ALIAAASMGY TEIVSYLLDL PEKDEEEVER
AQINSFDSLW GETALTAAAG RGKLEVCRLL LEQGAAVAQP NRRGAVPLFS TVRQGHWQIV
DLLLTHGADV NMADKQGRTP LMMAASEGHL GTVDFLLAQG ASIALMDKEG LTALSWACLK
GHLSVVRSLV DNGAATDHAD KNGRTPLDLA AFYGDAEVVQ FLVDHGAMIE HVDYSGMRPL
DRAVGCRNTS VVVTLLKKGA KIGPATWAMA TSKPDIMIIL LSKLMEEGDM FYKKGKVKEA
AQRYQYALKK FPREGFGEDL KTFRELKVSL LLNLSRCRRK MNDFGMAEEF ATKALELKPK
SYEAYYARAR AKRSSRQFAA ALEDLNEAIK LCPNNREIQR LLMRVEEECR QMQQQQQQQP
PQQQPQEQLP EETEPEPQHE DIYSVQDIFE EEYLEQDVEN VSVGLQTEAR PSQGLPIIQS
PPSSPAHRDS AYISSSPLGS HQVFDFRSSS SVGSPTRQGY QSTSPALSPT HQNSHYRPSP
PHTSPAHQGG SYRFSPPPVG GQGKEYPSPP PSPLRRGPQY RASPPAESMN VYRSQSGSPV
RYQQETNVSQ LPGRPKSPLS KMAQRPYQMP QLPVAVPQQG LRLQPAKAQI VRSNQPSSAV
HSSTVISTGA YGQVAHSMAS KYQSSQGDIG VTQSRLVYQG SIGGIVGDGR PVQHVQASLS
AGAICQHGGL TKEDLPQRPS SAYRGGVRYS QTPQIGRSQS ASYYPVCHSK LDLERSSSQL
GSPDVSHLIR RPISVNPNEI KPHPPTPRPL LHSQSVGLRF SPSSNSISSA SNLTPTFRPS
SSIQQMEIPL KPAYDRSCDE LSPVSPTQGG YPSEPTRSRT TPFMGIIDKT ARTQQYPHLH
QQNRTWAVSS VDTVLSPTSP GNLPQPESFS PPSSISNIAF YNKTNNAQNG HLLEDDYYSP
HGMLANGSRG DLLERVSQAS SYPDVKVART LPVAQAYQDN LYRQLSRDSR QGQTSPIKPK
RPFVESNV
//
