ID F6SUX6_ORNAN Unreviewed; 500 AA.
AC F6SUX6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Probable RNA-binding protein 46 {ECO:0000256|ARBA:ARBA00021018};
DE AltName: Full=RNA-binding motif protein 46 {ECO:0000256|ARBA:ARBA00030581};
GN Name=RBM46 {ECO:0000313|Ensembl:ENSOANP00000003396.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000003396.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000003396.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000003396.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000003396.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000003396.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; F6SUX6; -.
DR STRING; 9258.ENSOANP00000003396; -.
DR Ensembl; ENSOANT00000003397.3; ENSOANP00000003396.2; ENSOANG00000002141.4.
DR eggNOG; KOG0117; Eukaryota.
DR GeneTree; ENSGT00940000155927; -.
DR InParanoid; F6SUX6; -.
DR OMA; QSYFMPE; -.
DR TreeFam; TF314932; -.
DR Proteomes; UP000002279; Chromosome 12.
DR Bgee; ENSOANG00000002141; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0051728; P:cell cycle switching, mitotic to meiotic cell cycle; IEA:Ensembl.
DR GO; GO:0007143; P:female meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0007140; P:male meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0048255; P:mRNA stabilization; IEA:Ensembl.
DR GO; GO:0048477; P:oogenesis; IEA:Ensembl.
DR GO; GO:0048515; P:spermatid differentiation; IEA:Ensembl.
DR CDD; cd19901; DSRM_RBM46; 1.
DR CDD; cd12484; RRM1_RBM46; 1.
DR CDD; cd12492; RRM2_RBM46; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR006535; HnRNP_R/Q_splicing_fac.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR044462; RBM46_DSR.
DR InterPro; IPR034434; RBM46_RRM1.
DR InterPro; IPR034435; RBM46_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01648; hnRNP-R-Q; 1.
DR PANTHER; PTHR21245; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; 1.
DR PANTHER; PTHR21245:SF3; RNA-BINDING PROTEIN 46-RELATED; 1.
DR Pfam; PF14709; DND1_DSRM; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 61..139
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 141..223
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 236..308
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 500 AA; 57097 MW; E7C40FDFDC95BBD3 CRC64;
MLEDSLDILN GCSKVRTGIQ NEAALLALME KTGYSMVQEN GQRKFGGPPP DWEGPPPPRG
CEVFVGKIPR DMYEDELVPV FERAGKIYEF RLMMEFSGEN RGYAFVMYTT KEAAQLAIRI
LNNFEIRPGK FIGVCVSLDN CRLFIGAIPK EKKKEEILDE MKNVTEGVVD VIVYPSATDK
SKNRGFAFVE YESHRAAAMA RRKLIPGTFQ LWGHTIQVDW ADPEKEVDEE TMQRVKVLYV
RNLMISTTEE TIKAEFNKFK PGAVERVKKL RDYAFVHFFN RDDAMTAMSV MNGKYIDGAG
IEVTLAKPVN KENTWRQHLN GHISPNSENL LLFPNKEEGH LKILGKPTFL PPRLNGQQSP
KQIPEIERYT YPYFPGTKLT PISMYSLKWN QFNSAVMHLD YYCNKNNWAP PEYYLYSTTS
QDGKILLVYK VVIPALSNGA QSYFMPDKLC TTLEDAKEMA AQFTLLHLVS LANCSHVGQR
PCVSNQASFF RRKCKNQYEN
//
