ID F6SX15_MACMU Unreviewed; 892 AA.
AC F6SX15; A0A5F8A4Y6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Spermatosis associated 5 {ECO:0000313|Ensembl:ENSMMUP00000073009.1};
GN Name=AFG2A {ECO:0000313|VGNC:VGNC:77952};
GN Synonyms=SPATA5 {ECO:0000313|Ensembl:ENSMMUP00000073009.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000073009.1, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000073009.1}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000073009.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001104133.1; XM_001104133.3.
DR AlphaFoldDB; F6SX15; -.
DR SMR; F6SX15; -.
DR STRING; 9544.ENSMMUP00000073009; -.
DR PaxDb; 9544-ENSMMUP00000009745; -.
DR Ensembl; ENSMMUT00000087260.1; ENSMMUP00000073009.1; ENSMMUG00000007422.4.
DR GeneID; 708640; -.
DR KEGG; mcc:708640; -.
DR CTD; 166378; -.
DR VEuPathDB; HostDB:ENSMMUG00000007422; -.
DR VGNC; VGNC:77952; AFG2A.
DR GeneTree; ENSGT00940000157323; -.
DR HOGENOM; CLU_000688_10_0_1; -.
DR InParanoid; F6SX15; -.
DR OMA; WPISEQF; -.
DR OrthoDB; 168438at2759; -.
DR Proteomes; UP000006718; Chromosome 5.
DR Bgee; ENSMMUG00000007422; Expressed in fibroblast and 21 other cell types or tissues.
DR ExpressionAtlas; F6SX15; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005819; C:spindle; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:1990275; F:preribosome binding; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:Ensembl.
DR CDD; cd19503; RecA-like_CDC48_NLV2_r1-like; 1.
DR CDD; cd19511; RecA-like_CDC48_r2-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR PANTHER; PTHR23077:SF171; ATPASE FAMILY PROTEIN 2 HOMOLOG; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 385..524
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 659..797
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 892 AA; 97588 MW; 4E85DCAA38AA1837 CRC64;
MSSKKNRKRL NQSAENGSPL PSAASSCAVA RAPSAGSDLA AAAGTLTVTN FLEKVDDRIP
KTFQNSLIHL GLNTMKSANI CIGRPVLLTS LNGKQEVYTA WPMAGFPGGK VGLSEMAQKN
VGVRPGDAIQ VQPLVGAVLQ AEEMDVALSD KDMEINEEEL TGCILRKLDG KIVLPGNFLY
CTFYGRPYKL QVLRVKGADG MTLGGPQSDF DTDAQRMAFE QSSMETSSLE LSLQLSQLDL
EDTRISTSGS TPCKPVDDRI TNKASDVLDV TQSPGDGSGL MLEEVAGVKC SFESAREGNE
QLTEEERLLK FSIGAKCSTD TFYFISSTTR VNFTEIDKNS KEQDNQFKVT YDMIGGLSSQ
LKAIREIIEL PLKQPELFKS YGIPAPRGVL LYGPPGTGKT MIARAVANEV GAYVSVINGP
EIISKFYGET EAKLRQIFAE ATLRHPSIIF IDELDALCPK REGAQNEVEK RVVASLLTLM
DGIGSEVSEG QVLVLGATNR PHALDAALRR PGRFDKEIEI GVPNAQDRLD ILQKLLRRVP
HLLTEAELLQ LANSAHGYVG ADLKILCNEA GLCALRRILK KQPNLPDVKV AGLVKITLND
FLQAMNDIRP SAMREIAIDV PNVSWSDIGG LENIKLKLKQ AVEWPLKHPE SFIRMGIQPP
KGILLYGPPG CSKTMIAKAL ANESGLNFLA IKGPELMNKY VGESERAVRE TFRKARAVAP
SIIFFDELDA LAVERGSSLG AGNVADRVLA QLLTEMDGIE QLKDVTILAA TNRPDRIDKA
LMRPGRIDRI IYVPLPDAAT RREIFKLQFH SMPVSNEVDL DELILQTDAY SGAEIVAVCR
EAALLALEED IQANLIMKRH FTQALSTVTP RIPESLRRFY EDYQEKSGLH TL
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