ID F6T1Y2_MOUSE Unreviewed; 645 AA.
AC F6T1Y2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Rho GTPase activating protein 44 {ECO:0000313|Ensembl:ENSMUSP00000115612.2};
DE Flags: Fragment;
GN Name=Arhgap44 {ECO:0000313|Ensembl:ENSMUSP00000115612.2,
GN ECO:0000313|MGI:MGI:2144423};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115612.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000115612.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115612.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000115612.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115612.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SwissPalm; F6T1Y2; -.
DR MaxQB; F6T1Y2; -.
DR PeptideAtlas; F6T1Y2; -.
DR ProteomicsDB; 370104; -.
DR Antibodypedia; 47980; 118 antibodies from 21 providers.
DR Ensembl; ENSMUST00000130420.8; ENSMUSP00000115612.2; ENSMUSG00000033389.17.
DR UCSC; uc007jkt.1; mouse.
DR AGR; MGI:2144423; -.
DR MGI; MGI:2144423; Arhgap44.
DR VEuPathDB; HostDB:ENSMUSG00000033389; -.
DR GeneTree; ENSGT00940000157296; -.
DR HOGENOM; CLU_013806_0_1_1; -.
DR ChiTaRS; Arhgap44; mouse.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000033389; Expressed in medial vestibular nucleus and 214 other cell types or tissues.
DR ExpressionAtlas; F6T1Y2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF13; RHO GTPASE-ACTIVATING PROTEIN 44; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|MaxQB:F6T1Y2,
KW ECO:0007829|PeptideAtlas:F6T1Y2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1..124
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 130..320
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 32..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..447
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..562
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..618
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000115612.2"
SQ SEQUENCE 645 AA; 69916 MW; A0F0B96F023FBCC1 CRC64;
XLAEVEIPNI QKQRKHLAKL VLDMDSSRTR WQQTSKSSGL SSSLQPAGAK ADALREEMEE
AANRVEICRD QLSADMYSFV AKEIDYANYF QTLIEVQAEY HRKSLTLLQA VLPQIKAQQE
AWVEKPSFGK PLEEHLMISG REIAFPIEAC VTMLLECGMQ EEGLFRVAPS ASKLKKLKAA
LDCCVVDVQE YSADPHAIAG ALKSYLRELP EPLMTFELYD EWIQASNIQE QDKRLQALWN
ACEKLPKANH NNIKYLIKFL SKLSEYQDVN KMTPSNMAIV LGPNLLWPQS EGNITEMMTT
VSLQIVGIIE PIIQHADWFF PGEIEFNLTG SYGSPVHVNH NANYSSMPSP DMDPADRRQP
EQARRPLSVA TDNMMLEFYK KDGLRKIQSM GVRVMDTSWV ARRGSSAGRK ASCAPPSMQP
PAPPSELAAP LPSPLPEQVP DSPATPAPAL SPSGASLQPT PERPSVSKSK ELSPGSGQKG
SPGSIQGTPC PGTQLGPQPA ASPSQLPADQ SPHTLRKVSK KVAPIPPKVP FVQPGTVSDQ
PVGQPSPVSL SPTPPSTPSP YGLSYPPGYS MASGQLSPAS APPLASPSVF TSTLAKSRPT
PKPRQRPTLP PPQPPSVSLS ASSPQSTEHP MLDGMSPGES MSTAV
//
