ID   F6T6M4_CALJA            Unreviewed;       493 AA.
AC   F6T6M4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 3.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=Aspartyl aminopeptidase {ECO:0000256|ARBA:ARBA00015118};
DE            EC=3.4.11.21 {ECO:0000256|ARBA:ARBA00011965};
GN   Name=DNPEP {ECO:0000313|Ensembl:ENSCJAP00000045339.3};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000045339.3, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000045339.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000045339.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of an N-terminal aspartate or glutamate from a
CC         peptide, with a preference for aspartate.; EC=3.4.11.21;
CC         Evidence={ECO:0000256|ARBA:ARBA00001335};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBUNIT: Tetrahedron-shaped homododecamer built from six homodimers.
CC       {ECO:0000256|ARBA:ARBA00011395}.
CC   -!- SIMILARITY: Belongs to the peptidase M18 family.
CC       {ECO:0000256|ARBA:ARBA00008290, ECO:0000256|RuleBase:RU004386}.
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DR   AlphaFoldDB; F6T6M4; -.
DR   STRING; 9483.ENSCJAP00000045339; -.
DR   Ensembl; ENSCJAT00000061059.4; ENSCJAP00000045339.3; ENSCJAG00000011753.6.
DR   eggNOG; KOG2596; Eukaryota.
DR   GeneTree; ENSGT00390000003164; -.
DR   InParanoid; F6T6M4; -.
DR   OMA; GPILKVN; -.
DR   TreeFam; TF300487; -.
DR   Proteomes; UP000008225; Chromosome 6.
DR   Bgee; ENSCJAG00000011753; Expressed in heart and 6 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05658; M18_DAP; 1.
DR   Gene3D; 2.30.250.10; Aminopeptidase i, Domain 2; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023358; Peptidase_M18_dom2.
DR   PANTHER; PTHR28570; ASPARTYL AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR28570:SF3; ASPARTYL AMINOPEPTIDASE; 1.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
DR   SUPFAM; SSF101821; Aminopeptidase/glucanase lid domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW   ECO:0000256|RuleBase:RU004386};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004386};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004386};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU004386};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU004386};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004386}.
SQ   SEQUENCE   493 AA;  54390 MW;  A36D31937A64553B CRC64;
     MGLSLSAAFV LNSWLAGYHK VAMTGKASKD AVHTAAKELL KFVNSSPSPF HAVAECRNRL
     LQAGFSELKE TEKWDIKPEC KYFMTRNSST IIAFAVGGQY VPGNGFSLIG AHTDSPCLRV
     KRRSRRSQVG FQQVGVETYG GGIWSTWFDR DLTLAGRLIV KCPTSGQLEQ RLVHVERPIL
     RIPHLAIHLQ RNINENFGPN TEMHLVPILA TAVQEELEKG TPEPGPLNST DERHHSVLMT
     LLCTHLDLSP KDIIEMELCL ADTQPAVLGG AYDEFIFAPR LDNLHSCFCA LQALIDSCAG
     PGSLAMDPHV RMITLYDNEE VGSESAQGAQ SLLTELVLRR ISASYYHPTA FEEAIPKSFL
     ISADMAHAVH PNYLDKHEEN HRPLFHKGPV IKVNSKQRYA SNAVSEALIR EVANKVNVPL
     QDLMVRNDSP CGTTIGPILA SRLGLRVLDL GSPQLAMHSI REMACTTGVL QTLTLFKGFF
     ELFPSLSHNL LVD
//