ID F6TBW4_CIOIN Unreviewed; 947 AA.
AC F6TBW4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Zinc finger RNA-binding protein {ECO:0000313|Ensembl:ENSCINP00000010046.3};
GN Name=LOC778849 {ECO:0000313|Ensembl:ENSCINP00000010046.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000010046.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000010046.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6TBW4; -.
DR STRING; 7719.ENSCINP00000010046; -.
DR Ensembl; ENSCINT00000010046.3; ENSCINP00000010046.3; ENSCING00000004862.3.
DR GeneTree; ENSGT00940000167192; -.
DR HOGENOM; CLU_340554_0_0_1; -.
DR InParanoid; F6TBW4; -.
DR TreeFam; TF320194; -.
DR Proteomes; UP000008144; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR CDD; cd19854; DSRM_DHX9_rpt1; 1.
DR Gene3D; 1.10.1410.40; -; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR044445; DHX9_DSRM_1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR006561; DZF_dom.
DR InterPro; IPR049402; DZF_dom_C.
DR InterPro; IPR049401; DZF_dom_N.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45762; ZINC FINGER RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR45762:SF19; ZINC-FINGER PROTEIN AT 72D, ISOFORM B; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF20965; DZF_C; 1.
DR Pfam; PF07528; DZF_N; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00572; DZF; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS51703; DZF; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 242..311
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 591..947
FT /note="DZF"
FT /evidence="ECO:0000259|PROSITE:PS51703"
FT REGION 30..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 507..541
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 160..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 947 AA; 106652 MW; 5AFF7FBE80655F7B CRC64;
YKMAANYFGF TSGGNNQQYN IGTTGNYGGN YGIQQQQQPA QNNYMQPPRA IQPPQQQTYV
AYGHPTASGG ASVPSTSYPN TYSYQSQQQQ QQQQQTGFNK PAVQQSNQHQ YYQQQQQPRN
PPTQTNTANS STAYFTNNNT QNSAMQIKQP APQPVYNQPS PPVTSNFNQR QSQQSQQNIS
NYEKALINAA SSIYQQHSTP TGVTGGGGAS NLSAAYIKQL PYWKQKRLQQ VKDPNKPIVA
TEVKAYLYAW LSKKKARPDY NITAHGSHPY RQTYVCEIVV HGYDYVAKGS AGNKKDSQTR
AAWDFCDYLV REKLMTESEL PIRDAKFAAT NNKMPASYKP QSYQETKVGI AMKKALSNKV
NFVGGNTLHL SGGVNTVIKS TPTAYPPITS TSTPTFKAPT PANVPLMPPP PAPPVMKPIC
QETIKEEIKD SAEIESKNAP VGEDYVTQVW TDGRVIRYRC KLCECEFNDP SAKALHIRGR
RHRLSYKKKV DPNIEVEVKL NPKQKSLMEM KMRMEAKKEA AMEQQKKRME WQMEMRKREE
EDIRLYEQEL YYRYKEELSL FEEEVSYCRL SGTPVPPYLA PPNKPHLKFF RPNDANGNEG
QLSRDDQLIM KKHKNIYPTP EELEAVQSTV QTVETAFKDV SRTIHEQEMK VFAASHGTRK
RAQPQRLITA VVRVGELSKG LLLTGDLHVA LVLMCNVKPT KTMLNRVAGH LPKQLGNVSD
ENFVMKIMVE DAAILLATKS VPVVTIRITL TSTSMRNPCP DAEESATKNK KPDPPDILDS
DKCCDALAAL RRAKWFQAKV TPYHSCLVIC RIFKDFATRY NQLVPLKSWA IELLTERSYT
SATSTLSPTS CLQRVLEVLS MGVLLPDGPG IRDPCEKEPT DAAGNLSLQQ REDITTLAQR
LLRLVTFGKM FKILDLKYEP KPQVQKRSAE NGEFDNTGVK KIKVEMH
//
