ID F6TH03_ORNAN Unreviewed; 285 AA.
AC F6TH03;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Keratin 222 {ECO:0000313|Ensembl:ENSOANP00000017365.3};
GN Name=KRT222 {ECO:0000313|Ensembl:ENSOANP00000017365.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000017365.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000017365.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017365.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000017365.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017365.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; F6TH03; -.
DR STRING; 9258.ENSOANP00000017365; -.
DR Ensembl; ENSOANT00000017368.3; ENSOANP00000017365.3; ENSOANG00000010960.3.
DR eggNOG; ENOG502QQ07; Eukaryota.
DR GeneTree; ENSGT00940000159655; -.
DR HOGENOM; CLU_101833_0_0_1; -.
DR InParanoid; F6TH03; -.
DR OMA; EEGCLHT; -.
DR OrthoDB; 4111230at2759; -.
DR TreeFam; TF332442; -.
DR Proteomes; UP000002279; Chromosome 11.
DR Bgee; ENSOANG00000010960; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR PANTHER; PTHR47082; KERATIN-LIKE PROTEIN KRT222; 1.
DR PANTHER; PTHR47082:SF1; KERATIN-LIKE PROTEIN KRT222; 1.
DR Pfam; PF00038; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 1..150
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 31..149
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 285 AA; 32651 MW; 8A25100A1BC8E669 CRC64;
MELSQLLNEI RANYARLLTR NQIETVLSTR IQLEEDVNQK MDRDVEALKA ARAELKQARR
EWHHLQVEIE SLHAVERGLE NSLHASEQNH QLQLQDLEAV IEGLEKELQE VRHGIEKQLQ
EHEVLLNAKM RLEQEIATYR RLLEKEEIRY YGSIQAGKED VKPSTSRVGF ILPSDVTHKP
GNEKVETVTT QAVLNGSIVK ESAEARGTIQ TEKVDEVIKE WEGSFFKDNP HLRKKSVSLR
FDLHLAATDE GCLQTKQDNL PDIEVRLIMR RSCSIPSIKP ASSAN
//
