ID F6TQ83_HORSE Unreviewed; 407 AA.
AC F6TQ83;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=acid phosphatase {ECO:0000256|ARBA:ARBA00012646};
DE EC=3.1.3.2 {ECO:0000256|ARBA:ARBA00012646};
GN Name=ACP3 {ECO:0000313|Ensembl:ENSECAP00000018468.2,
GN ECO:0000313|VGNC:VGNC:52298};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018468.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000018468.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018468.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000018468.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018468.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR AlphaFoldDB; F6TQ83; -.
DR Ensembl; ENSECAT00000022354.4; ENSECAP00000018468.2; ENSECAG00000021043.4.
DR VGNC; VGNC:52298; ACP3.
DR GeneTree; ENSGT00940000160450; -.
DR HOGENOM; CLU_030431_1_1_1; -.
DR TreeFam; TF312893; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000021043; Expressed in zone of skin and 19 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; ISS:CAFA.
DR GO; GO:0005886; C:plasma membrane; ISS:CAFA.
DR GO; GO:0012506; C:vesicle membrane; ISS:CAFA.
DR GO; GO:0008253; F:5'-nucleotidase activity; ISS:CAFA.
DR GO; GO:0003993; F:acid phosphatase activity; ISS:CAFA.
DR GO; GO:0052642; F:lysophosphatidic acid phosphatase activity; ISS:CAFA.
DR GO; GO:0016791; F:phosphatase activity; ISS:CAFA.
DR GO; GO:0042131; F:thiamine phosphate phosphatase activity; ISS:CAFA.
DR GO; GO:0046085; P:adenosine metabolic process; ISS:CAFA.
DR GO; GO:0016311; P:dephosphorylation; ISS:CAFA.
DR GO; GO:0060168; P:positive regulation of adenosine receptor signaling pathway; ISS:CAFA.
DR GO; GO:0051930; P:regulation of sensory perception of pain; ISS:CAFA.
DR GO; GO:0006772; P:thiamine metabolic process; ISS:CAFA.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR11567:SF32; PROSTATIC ACID PHOSPHATASE; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
DR PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..407
FT /note="acid phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018778062"
SQ SEQUENCE 407 AA; 46421 MW; AEB19413CE863BF9 CRC64;
MRAAPLLGAS AARLPLSLFL LLSFRLDRGV GAKELKFVTL VFRHGDRSPI ETFPNDPIKE
SSWPQGFGQL TQLGMEQHYE LGEYIRKRYG KFLNETYKRE QVYIRSTDVD RTLMSSMTNL
AALFPPEGVS IWNPGLPWQP IPVHTVPLSE DRLLYLPFRD CPRFQELESE TLNSEEFQKR
LHPYKDFIET LPKLSGYHGQ DLFGIWSKVY DPLFCESVHN FTLPSWATED VMTKLRELSE
LSLLSLYGIH KQEEKSRLQG GVLVGEILNH MKSATQPSNH RKLVMYSAHD TTVSGLQMAL
NVYNGILPPY AACHLMELYS EAGSEDHPCC CLLPGVWRPS GAAVYPHPPW ALLAERLLSE
HLNRRLNEGR HARPIFVTRH RSPMQHSKDR LSPCGHHSAH ICPFKSA
//
