ID F6UD31_ORNAN Unreviewed; 1914 AA.
AC F6UD31;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Myosin-2 {ECO:0000256|ARBA:ARBA00039812};
DE AltName: Full=Myosin heavy chain 2 {ECO:0000256|ARBA:ARBA00041436};
DE AltName: Full=Myosin heavy chain 2a {ECO:0000256|ARBA:ARBA00042414};
DE AltName: Full=Myosin heavy chain, skeletal muscle, adult 2 {ECO:0000256|ARBA:ARBA00041387};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000005357.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000005357.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000005357.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Muscle contraction. Required for cytoskeleton organization.
CC {ECO:0000256|ARBA:ARBA00037212}.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2). Interacts with GCSAM.
CC {ECO:0000256|ARBA:ARBA00038665}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 9258.ENSOANP00000005357; -.
DR Ensembl; ENSOANT00000005358.3; ENSOANP00000005357.3; ENSOANG00000042276.1.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000161336; -.
DR HOGENOM; CLU_000192_8_1_1; -.
DR InParanoid; F6UD31; -.
DR OMA; IHIIEVM; -.
DR TreeFam; TF314375; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000042276; Expressed in testis and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0032982; C:myosin filament; IBA:GO_Central.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF39; MYOSIN-2; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..757
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 634..656
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1103..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1914 AA; 220511 MW; 0442D1CE6CC0FD17 CRC64;
MSSDQEMAVF GEAAPFLRKS EKERIEAQNK PFDAKTSVFA VEPKESFVKS TIQSREGGKV
TVKTEGGATL TVRDDQVFPM NPPKFDKIED MAMMTHLHEP AVLYNLKERY AAWMIYTYSG
LFCVTVNPYK WLPVYNPEVV AAYRGKKRQE APPHIFSISD NAYQFMLTDR ENQSILITGE
SGAGKTVNTK RVIQYFATIA VTGEKKKEEP GKMQGTLEDQ IISANPLLEA FGNAKTVRND
NSSRFGKFIR IHFGTTGKLA SADIETYLLE KSRVTFQLKA ERSYHIFYQI TSNKKPELIE
MLLITTNPYD YPFVSQGEIS VASIDDQEEL MATDSAIDIL GFTSEEKGAI YKLTGAVMHY
GNMKFKQKQR EEQAEPDGTE VADKAAYLQG LNSADLLKAL CYPRVKVGNE YVTKGQTVEQ
VTNSVGALAK AIYDKMFLWM VTRINQQLDT KQPRQYFIGV LDIAGFEIFD YNSLEQLCIN
FTNEKLQQFF NHHMFVLEQE EYKKEGIEWE FIDFGMDLAA CIELIEKPMG IFSILEEECM
FPKATDTSFK NKLYDQHLGK SANFQKPKPT KGKAEAHFSL IHYAGTVDYN ITGWLEKNKD
PLNETVVGLY QKSSLKTLAY LFSGAAAAAE AENLNKLMTN LRSTHPHFVR CIIPNETKTP
GAMEHELVLH QLRCNGVLEG IRICRKGFPS RILYADFKQR YKVLNASAIP EGQFIDSKKA
SEKLLGSIDV DHTQYKFGHT KVFFKAGLLG LLEEMRDEKL AQLMTRTQAR CRGFLMRVEY
QKMVERRESV FCIQYNVRAF MNVKHWPWMK LFFKIKPLLK SAETEKEMAT MKEEFEKTKE
ELAKSEAKRK ELEEKMVSLL KEKNDLQLQV QSEAEALADA EERCDQLIKT KIQLEAKIKE
VTERAEDEEE INAELTAKKR KLEDECSELK KDIDDLELTL AKVEKEKHAT ENKVKNLTEE
MAALDETIAK LTKEKKALQE AHQQTLDDLQ AEEDKVNTLT KAKTKLEQQV DDLEGSLEQE
KKLRMDLERA KRKLEGDLKL AQESIMDVEN EKQQIDEKLK KKEFEISNLQ SKIEDEQALG
IQLQKKIKEL QARIEELEEE IEAERASRAK AEKQRSELSR ELEEISERLE EAGGATSAQI
EMNKKREAEF QKMRRDLEEA TLQHEATAAA LRKKHADSVA ELGEQIDNLQ RVKQKLEKEK
SEMKMEIDDL ASNMETVSKA KGNLEKMCRT LEDQVSELKT KEEEQQRLIN DLSAQRGRLQ
TEAGEYSRQL DEKEALVSQL SRGKQAFTQQ IEELKRQLEE ETKAKNALAH ALQSSRHDCD
LLREQYEEEQ ESKAELQRAM SKANSEVAQW RTKYETDAIQ RTEELEEAKK KLAQRLQDAE
EHVEAVNAKC ASLEKTKQRL QNEVEDLMID VERTNAACAA LDKKQRNFDK ILAEWKQKYE
ETQAELEASQ KESRSLSTEL FKMKNAYEES LDHLETLKRE NKNLQQEISD LTEQIAEGGK
HIHELEKVKK QIEQEKCELQ AALEEAEASL EHEEGKILRI QLELNQVKSE IDRKIAEKDE
EIDQLKRNHL RVVETMQTAL DAEIRSRNDA IRIKKKMEGD LNEMEIQLNH ANRMAAEALR
NYRNTQGILK DTQLHLDDAL RGQEDLKEQL AMVERRANLM QAEVEELRAA LEQTERSRKI
AEQELLDASE RVQLLHTQNT SLINTKKKLE TDISQIQGEM EDMVQEARNA EEKAKKAITD
AAMMAEELKK EQDTSAHLER MKKNMEQTVK DLQLRLDEAE QLALKGGKKQ IQKLEARVRE
LEGEVDSEQK RNVETVKGLR KHERRVKELT YQTEEDRKNI LRLQDLVDKL QAKVKAYKRQ
AEEAEEQSNT NLSKFRKIQH ELEEAEERAD IAESQVNKLR VKSREVHTKI VSEE
//
