ID F6UJ81_XENTR Unreviewed; 741 AA.
AC F6UJ81;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=stat4 {ECO:0000313|Ensembl:ENSXETP00000010124,
GN ECO:0000313|RefSeq:XP_031749083.1,
GN ECO:0000313|Xenbase:XB-GENE-478992};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000010124};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000010124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000010124};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000010124}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031749083.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031749083.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031749083.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR RefSeq; XP_031749083.1; XM_031893223.1.
DR Ensembl; ENSXETT00000010124; ENSXETP00000010124; ENSXETG00000004662.
DR AGR; Xenbase:XB-GENE-478992; -.
DR Xenbase; XB-GENE-478992; stat4.
DR eggNOG; KOG3667; Eukaryota.
DR HOGENOM; CLU_014189_3_0_1; -.
DR OMA; EGSHMVT; -.
DR TreeFam; TF318648; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Bgee; ENSXETG00000004662; Expressed in thymus and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10375; SH2_STAT4; 1.
DR CDD; cd16854; STAT4_CCD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR046991; STAT4_CCD.
DR InterPro; IPR035856; STAT4_SH2.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF19; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 571..702
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 195..222
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 741 AA; 85144 MW; 838CDCD44726E7E4 CRC64;
MSQWNQVQRL EQRFLEQVDQ FYDDTFPMEV RHLLASWIEG QDWDAASNSD SLATVLLHNL
MIQIEEELNR VSQEKNLLLR HNLKRIKQHL LGKYHGNPMH MAMIVSNCLR EERRILAAAS
MPIQGPFEKS LQTNLISERQ RVLENKVAAI KNSAQVTEQD VKYLEDLQDE FDFRFKTIQS
KDTTDKHNIL IEQECYKLQE MLNALDQKRK EALRKMSQII DEIDTLMGKS LTEELKNWKR
RQQIACIGGP LHGSLDQIQN WFTLLAESLF QLRRQIQKLD ELWTKVTYEG DPIPLQKQYL
LDRVICLILS VFQSSFIVER QPCMPTHPQR PLVLKTEIQF TVKLRLLVKL PELNYQLRVK
ATIDKDPSFN LSNRRFVLFG TPVKVMSIED SANGSLSVEM RHLKPKESKS NSGNKGHEGV
HMVTEELHSI SFETQVCLYG LAIDLETSSL PVVMISNVSQ LPSAWASVIW YNLFSSEPQN
HAFFANPPTA SLNQLLEVLS WQFSSYVGRG LNSEQLNMLG DKLIGVPVNQ GDNHISWVKF
CKEHLPGKPF SFWAWIEGIL ELIKKYLLSI WIDGCIMGFV SKEKERALLK DKIPGTFLLR
FSESHLGSIT FTWVDLSDTG EVRFHSVEPY NKGRLNALPF PDILRTYKVI EAENAPENPL
LYLYPDVPKD KAFGKHYNSH QNEVSQPTEN VKGYVPSVFI PMSKLPTNGS SSPSPMDLPM
SPSIFAALRE QLTYTEIEND A
//
