ID F6URT5_HORSE Unreviewed; 417 AA.
AC F6URT5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=G protein-coupled receptor 19 {ECO:0000313|Ensembl:ENSECAP00000020921.2};
GN Name=GPR19 {ECO:0000313|Ensembl:ENSECAP00000020921.2,
GN ECO:0000313|VGNC:VGNC:18534};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020921.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020921.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020921.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020921.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020921.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003365221.1; XM_003365173.3.
DR RefSeq; XP_005611005.1; XM_005610948.2.
DR AlphaFoldDB; F6URT5; -.
DR STRING; 9796.ENSECAP00000020921; -.
DR PaxDb; 9796-ENSECAP00000020921; -.
DR Ensembl; ENSECAT00000025157.3; ENSECAP00000020921.2; ENSECAG00000023507.3.
DR Ensembl; ENSECAT00000081135.1; ENSECAP00000071056.1; ENSECAG00000023507.3.
DR Ensembl; ENSECAT00000086492.1; ENSECAP00000085953.1; ENSECAG00000023507.3.
DR Ensembl; ENSECAT00000093437.1; ENSECAP00000090613.1; ENSECAG00000023507.3.
DR Ensembl; ENSECAT00000100068.1; ENSECAP00000078995.1; ENSECAG00000023507.3.
DR Ensembl; ENSECAT00000107285.1; ENSECAP00000062961.1; ENSECAG00000023507.3.
DR Ensembl; ENSECAT00000110258.1; ENSECAP00000064120.1; ENSECAG00000023507.3.
DR Ensembl; ENSECAT00000126740.1; ENSECAP00000086900.1; ENSECAG00000023507.3.
DR Ensembl; ENSECAT00000131759.1; ENSECAP00000057454.1; ENSECAG00000023507.3.
DR GeneID; 100066597; -.
DR KEGG; ecb:100066597; -.
DR VGNC; VGNC:18534; GPR19.
DR GeneTree; ENSGT00940000160365; -.
DR HOGENOM; CLU_009579_20_0_1; -.
DR InParanoid; F6URT5; -.
DR OMA; QLWHPRE; -.
DR TreeFam; TF331630; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000023507; Expressed in brainstem and 18 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd15008; 7tmA_GPR19; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR047829; GPR19_7tmA.
DR PANTHER; PTHR24243; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24243:SF224; G-PROTEIN COUPLED RECEPTOR 19-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 84..332
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 417 AA; 47792 MW; 6C6183D866CFC715 CRC64;
MNMVFAHRMD DSKPPLVVPT LLVPLQNHSC TETATPLPSR DLTEFSEEHS WMSNRTDVQY
GPKPGEVATA SIFFGALWLF SIFGNSLVCL VIHRSRRTQS TTNYFVVSMA CADLLISVAS
TPFVLLQFAT GRWTLGSAMC KVVRYFQYLT PGVQIYVLLS ICIDRFYTIV YPLSFKVSRE
KAKKMIAASW VFDAAFVTPV FFFYGSNWDN HCNYFLPSSW EGTAYTVIHF SVSFVIPSVL
IILFYQKVIK YIWRIGTDGR TVRRTMNIVP RTKVKTIKMF LILNLLFLLS WLPFHVAQLW
HPHERDYKKS SIVFTAITWI SFSSSAAKPT LYSIYNANFR RGMKETFCMS SMKCYRSNAY
TITTSSRMAK KNYVGISEIP PTAKTVTKDS IYDSFDREAK EKKLAWPINS NPPNTFV
//
