ID F6UZL8_XENTR Unreviewed; 2393 AA.
AC F6UZL8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Chondroitin sulfate proteoglycan 4 {ECO:0000313|Ensembl:ENSXETP00000000764, ECO:0000313|RefSeq:XP_002941158.3};
GN Name=cspg4b {ECO:0000313|Ensembl:ENSXETP00000000764,
GN ECO:0000313|Xenbase:XB-GENE-5893460};
GN Synonyms=cspg4 {ECO:0000313|RefSeq:XP_002941158.3};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000000764};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000000764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000000764};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000000764}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002941158.3}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002941158.3};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002941158.3};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR RefSeq; XP_002941158.3; XM_002941112.5.
DR STRING; 8364.ENSXETP00000000764; -.
DR Ensembl; ENSXETT00000000764; ENSXETP00000000764; ENSXETG00000000363.
DR KEGG; xtr:100145673; -.
DR AGR; Xenbase:XB-GENE-5893460; -.
DR Xenbase; XB-GENE-5893460; cspg4b.
DR eggNOG; KOG3597; Eukaryota.
DR HOGENOM; CLU_000473_1_0_1; -.
DR OMA; EELHFMV; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000000363; Expressed in skeletal muscle tissue and 11 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR45739:SF12; CHONDROITIN SULFATE PROTEOGLYCAN 4-LIKE ISOFORM X2; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 13.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS51854; CSPG; 10.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2268..2290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..200
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 210..388
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REPEAT 429..524
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 665..763
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 897..991
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1130..1220
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1242..1340
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1358..1449
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1473..1563
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1580..1679
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1704..1803
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1835..1927
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
SQ SEQUENCE 2393 AA; 267054 MW; E983CEEE7898F9E9 CRC64;
MGPCGSLSAY VYVLAVVVSS SRLHTLAASF YGESFVELKT AESFSKSTLH LKFRTSKPDG
LLFLAAGKKQ YSLLELHSGH VQGKIDFGEG EQILLPKNGP RLDDLEWHVV KLHHENADVV
LSVDQHINSS LRVAGGLQEF SVHYGLYVGG FSDLDVSYAK ILPNHFRGCL DEVVFNNQEL
LSSLRPYPGL KNVHEVSLGC SDEFFVSEDD PMSLFSSKSY VVLPPWTLEE GGVWECLLQS
SAGKGLLLYQ SGSVGNFISL EIQDYILKAH LRKGNSLIQL STLNPITEHK WHHIKLKLSA
KHFHLTLDEE TVKASLTLNS KIAHLNGPLF VGGVNDAARK VLISSLGAVP GKHAKVVSFK
GCIKNIKVNS KIYGLKNALA TKDVSPGCKT EMLLTTSPVN KADEMHLNTA APSTSLVTTT
TAATQNNAKH HFIVLNNLVV QEGGRAPLQS KHIKLNLDFK KLGVRQSQIT FKIVKYPQSG
QLKIDVPTTQ NKDVFTMLDL WHGRITYIHD GSEGTNDNFT FTVTATSKNE IPFYLDGTQQ
HLFSITVTPT NDAPELSLPE GNLFVLLENS KKRLPANLLK VSDVDTDPQN LNFVVLGNLN
ADAGFLVNGR DAGKGISIFS YSELLDGNIF YVHHGVKNSR LVLRVSDGDK VSNTVVLRIL
AVPLDYKLVN NTGIVVTQGE STLILTSNLG VDTNAENQDM EIRYDVMELP KYGQIQRRSV
GNEWKSANSF TQRSLERERI RYLSTFNEVQ EADGTEYFKF KVTIANKSSE EYLFPISVQW
LKYTLVKHSA LNVENRKPVT FTTDNIFSVV TGISTAAKEI YFKVLSLPKK GRILVNKNNL
KENDMFSQVD ITDLKVEYEL TDQPRQDSRD FFSFSLFTKH AESKPHEFQI NIKADLNSIF
LTNNGLSLAE GDSKLITRNE LFVQTLNNKT FSYKVQKSPQ HGKLRLINFS DSVLSNDNIT
AFSSQDILGE RLMYAHDDTE TTADSFTVLA TSLSSEDESP NGNKVHAEVI FNISIELKND
EKPIRMVDKL FHVVRNGQRL VTLEDLCYHD SDTDFTDGQL LYTRRGIPNG DLVSANDPST
KLYQFTQEDL EKKRVLFMHQ GSDYGRFVLF VTDGKHYTSS LLEVSASEPY VKVVNNTGLL
VQKGKEQIIT ISNISIATNL YIESYKEIVY NIASSPKYGK ILVQGSAAES FTHLDIKSGH
VTFRHDDSNN LLDAFNLTVT LKNIAVNIEI KVRVYLESHQ RLPTVLNLNI LVVEQGRPVK
IDERKLQVVH EDNLPKEIIY SVISPPSHGY IRKFESVEGH LTAEKNSILT FTQQDINDGL
IHYVQSDPGQ LQDNFTVDIT NGIRIISGIT VSVDIIPLLI PLATQNITVK EGASKALTDE
QLNISNKHFA GLNFEFEVID LPKNGYIENT RFPGIKLNRF TRKQVEQELI YYVHDDSETL
NDNFTILVND TDLSKHSLPS TIFVTVSPIN DEFPFITANS IFRVWVGSVT EVTCEDLCAK
DKDTSPSDLV FSITPPSNGH LALKSYPNKS ILNFTQQHID DKHLVFVHSG SMSGGFNFQV
TDGLNFAPRQ IFSITARTLV INLEANKGLD VFPGTRRAIT SDHLKAVTND ESNMKNRTVT
FTVVVPPKHG LLMFGLHNAT EEVSGFSQLM VDEGVIFYEH TDNEALLWNT QDSFTFTASS
PPAFLESSVF LITISYEIND PARKSRLRAN TGASVEEGGK VLIDKSKLDG SNLLLKLPET
QRASYEVWYQ VTSLPNHGMI IVGDRNITKD KPNFSQYIVN KFGITYMHDG SESLADRFTF
ATWLNLKSKS AVKPDTDVLE EMFNFTIIGV NDQSPELKTK RPYLKVLQGQ MIAIGSDNLN
VEDLDNPPED IKYTIISTPN NGFLANHENL NASVDHFTQA DINDGHVWFV QDGSTSSGVF
YFSVTDGKHK PLYKLFNIDV TSVSITLVNQ TNLVLTQSQT FLPITNMHLA ATTDGRSKEI
LYEVVQMPTY GQVMIDYAPV TKFGQIDLNL GKVKYHVRNL TESQDSFELM AMTSESNLTG
LVLNVTLKPL VHVISKLEIP TETIYIIQIK DLDASELANV TGSDPEFHII DEPGYGRLMR
RKMPQSDAYE DIAMFTQAEI ETGRVLLEVS ANLTYTEMQN DSFSFLLKAS NVPPALGVFS
YSVVPNDPLL FQAVTSEGYL SASTTESSHT SSVYEKRTPN YWLNNTSTVV PNIKNVPKWG
NRNRWGNQNN EELLFSEATT SSFREATVGA NPISPKAEAS QNGSSLSVII PLVILVLLIL
AAILIVWFLM KRKTKKAPQH VKSNSYSVVP QVPSPYMERS ATIPTVTVTP LQKSHEYVSV
SPLLPPRQAH TYASSSPSLT ENAQQNSWLH MDPEMLQHCR TTNPTLKNNQ YWV
//
