ID F6V3U1_MONDO Unreviewed; 2669 AA.
AC F6V3U1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=GCN1 activator of EIF2AK4 {ECO:0000313|Ensembl:ENSMODP00000019016.5};
GN Name=GCN1 {ECO:0000313|Ensembl:ENSMODP00000019016.5};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000019016.5, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000019016.5, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000019016.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GCN1 family.
CC {ECO:0000256|ARBA:ARBA00007366}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 13616.ENSMODP00000019016; -.
DR Ensembl; ENSMODT00000019359.5; ENSMODP00000019016.5; ENSMODG00000015221.5.
DR eggNOG; KOG1242; Eukaryota.
DR GeneTree; ENSGT00940000153612; -.
DR HOGENOM; CLU_000504_2_2_1; -.
DR InParanoid; F6V3U1; -.
DR OMA; KYATQRG; -.
DR TreeFam; TF105398; -.
DR Proteomes; UP000002280; Chromosome 3.
DR Bgee; ENSMODG00000015221; Expressed in hindlimb bud and 17 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0022626; C:cytosolic ribosome; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
DR GO; GO:0170011; F:stalled ribosome sensor activity; IEA:Ensembl.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0140469; P:GCN2-mediated signaling; IEA:Ensembl.
DR GO; GO:0006417; P:regulation of translation; IBA:GO_Central.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 6.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS50077; HEAT_REPEAT; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1363..1596
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1614..1652
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1656..1694
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 2004..2041
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 2669 AA; 292662 MW; 62FC01AEC8CBECCB CRC64;
MAADTQVSET LKRFAVKVTT ASVKERREIL NDLGKCVAGK DLPEGAVKGL CKLFCLTLHR
YRDAASRRAL QSAIQQLAEA QPEATAKNLL QSLQSSGIGG KAGVPSKSSG SAALLALSWT
CLLVRVVFPT RAKRQGETWK KLVEVQCLLL LEVLGGSHKH AVDGAVKKLN TLWKENPGLV
DQYLSIILSL EPNQNYAGML GLLVQFCTSQ KEMDVVNRHK SALLDFYLKN ILMSKVKPQR
YLLDNCAPVL RYISHSEFKD LVLPSLQKSL LRSPENVIET VSCLLASVTL DLSQYALDIV
KGLASQLKSN TPQLMDEAVI ALKNLARQCS DPSAMESLTR HLFAILGGSE GKLTIVSQKM
SVLSGIGSFS HHVVSGLSSQ ALSGTVAELF IPFLQQEVHE GTLVHAVSTL ALWCNRFTTE
VPRKVIEWLK KAFSLKTSTS AVRHAYLQCM LISFRGDTLL QGMDFLPLLI QIVEKAASQS
TQVSIVTEGV AAAVLICRLS VIDTQAEAKL NSFWQLIVDE KKQLFTSEKF LLLASEDAMC
TVLQLTERLL LDHPHRLPGS KVQQYHRALV AVLLSRTWHV RRQAQQTVRK LLSSLGGFML
AHGLLEELKA VLNSHKVLPM ESLVTESGEL SEQGKAYVPP RVLQETLCVI SGVPGLESDT
AETERLAQEM LIVTHHPSIV AVQSGLWPAL LAKMKIDPTD FITKHLDQIL PRITTQTPLN
QSSMNAMGSL SVLSPHRVLP QLISTITATV QNPALSQVTR EEFAIMKTPP GELYDKSVIP
SAQQDSTKKA NMKRENKAYS FKEQIIELEL KEEIKKKKGI KDEVQLTSKQ KEIMRAQLDK
EAQIRRRLQE LDSELEAALG LLDTVLSRNP PGLTQYIPAL VRSFLPLLKS PLAAPRIKNP
FLSLASCVMP PRLKPLGTLV SHVTLRLLRP ECVLDKSWCQ EDLSVATQRA VNLLHIHTIP
VKTGKGEPDA SPLSAPAFSL VFPFLKMVLT ETPNRSEDDE HLMVQILQIL TVHAQLRSSS
SPINQVLWVD ENGPELLPRT DMLRLLTGVI GTGSPRLQGL AADTLKALCA SSSGDDGCAF
AEQEEVDVLL QALRSPCASV RDTALQGLGE LQMVLPTPDS NEKNGLNLLR RLWVIKFDSE
EEIRKLAEKL WETMNLELQP DLCSLLIDDV IYHEAAVRQA GAEALSQAVA QYPRQAAEVM
GRLMEIYQEK LYRPPPILDA LGRVISESPP DQWEASCHGV LLSQYLDSSQ VKPLFQFFVP
DALNDRNPDV RKCMLDAALS TLNTHGKDNV NSLLPVFEEF LKDAPNDASY DAVRQSVVIL
MGSLAKHLDK SDPKVKPIVA KLVAALSTPS QQVQESVAGC LPPLVPAIKE DAGGMIQKLM
QLLLESDKYA ERKGAAYGLA GLVKGLGILS LKQQEMMTTL TDAIQDKKNF RRREGALFAF
EMLCTMLGKL FEPYVVHVLP HLLLCFGDGN QYVREAADDC AKAVMSNLSA HGVKLVLPSL
LAALEEESWR TKAGSVELLG AMAYCAPKQL SSCLPNIVPK LTEVLTDSHV KVQKAGQQAL
RQIGSVIRNP EILAIAPVLL DALTDPSRKT QQCLQTLLDT KFVHFIDAPS LALIMPIVQR
AFQDRSTDTR KMAAQIIGNM YSLTDQKDLA PYLPSVTPGL KASLLDPVPE VRTVSAKALG
AMVKGMGESC FEDLLPWLME TLTYEQSSVD RSGAAQGLAE VMAGLGVEKL EKLMPEIVAT
ASKVDIAPHV RDGYIMMFNY LPITFGDKFT PYVGPIIPCI LKALADENEF VRDTALRAGQ
RIISMYAETA IALLLPQLEQ GLFDDLWRIR FSSVQLLGDL LFHISGVTGK MTTETASEDD
NFGTAQSNKA IISALGVERR NRVLAGLYMG RSDTQLVVRQ ASLHVWKIVV SNTPRTLREI
LPTLFGLLLG FLASTCADKR TIAARTLGDL VRKLGEKILP EIIPILEEGL RSEKSDERQG
VCVGLSEIMK STSRDAVLFF SESLVPTARK ALCDPLEEVR EAAAKTFEQL HSTIGYQALE
DILPFLLKQL DDEEMSEFAL DGLKQVMAVK SRVVLPYLVP KLTSPPINTR VLAFLSSVAG
DALTRHLGVI LPAVMSALKE KLGTSEEQLE MANCQAVILS VDDDAGHRII IEDLLEATRS
PEVGMRQAAA IILNIYCSKS KADYTGHLRG LVSGLIRLFN DSNSVVLEES WDALNAITKK
LDAGNQLALI EDLHRDIRMV GNESKGEHVP GFCIPKKGVT SILPVLREGV LTGNPEQKEE
AARALGLVIR LTSADALKPS VVSITGPLIR ILGDRFSWNV KVALLETLSL LLAKVGIALK
PFLPQLQTTF TKALQDSNRA VRLKAADALG KLIAIHIKVD PLFTELLNGI RSTEDSGIRD
TMLQALRFVT QGAGAKVDTV IRKSLTTVLL GMLGHDEDAT RMASAGCLGE LCAFLAEEEL
NAVLQQHLLA DVSGIDWMVR HGRSLALSVA VNVAPDRLCT AKYSPSVQEM ILSNATADRI
PIAVSGIRGM GFLMKYHIES EGGNLPGKLT SLFIKCLQNP SSDIKLVAEK MIWWANKDHL
PSLDPQIIKP ILKALLDNTK DKNTSVRAYS DQAIVNLLKM REGDDLLQSV SKILDGVSLE
LLGESCRRSL KKLASQADSV EQIDDTILT
//
