ID F6V4A4_XENTR Unreviewed; 898 AA.
AC F6V4A4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Short transient receptor potential channel 6 isoform X1 {ECO:0000313|RefSeq:XP_002935616.2};
DE SubName: Full=Transient receptor potential cation channel, subfamily C, member 6 {ECO:0000313|Ensembl:ENSXETP00000012047};
GN Name=trpc6 {ECO:0000313|Ensembl:ENSXETP00000012047,
GN ECO:0000313|RefSeq:XP_002935616.2,
GN ECO:0000313|Xenbase:XB-GENE-1012076};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000012047};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000012047}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000012047};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000012047}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002935616.2}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002935616.2};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002935616.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_002935616.2; XM_002935570.5.
DR STRING; 8364.ENSXETP00000012047; -.
DR Ensembl; ENSXETT00000012047; ENSXETP00000012047; ENSXETG00000005481.
DR GeneID; 100493327; -.
DR KEGG; xtr:100493327; -.
DR AGR; Xenbase:XB-GENE-1012076; -.
DR CTD; 7225; -.
DR Xenbase; XB-GENE-1012076; trpc6.
DR eggNOG; KOG3609; Eukaryota.
DR HOGENOM; CLU_005716_4_2_1; -.
DR OMA; TWMELLI; -.
DR TreeFam; TF313147; -.
DR Reactome; R-XTR-114508; Effects of PIP2 hydrolysis.
DR Reactome; R-XTR-139853; Elevation of cytosolic Ca2+ levels.
DR Reactome; R-XTR-3295583; TRP channels.
DR Proteomes; UP000008143; Chromosome 2.
DR Bgee; ENSXETG00000005481; Expressed in 2-cell stage embryo and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR005462; TRPC6_channel.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF7; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR PRINTS; PR01647; TRPCHANNEL6.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_002935616.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 208..240
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 243..305
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 799..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 898 AA; 102761 MW; CA5FF002B261EFC8 CRC64;
MSQCEPYVSR NNNCPITAVR NESQDYLLMG TEDGAENSFH HYGYYPMQST ESRLSHRRQT
ILREKGRRQA NRGPAYMFND RSTSLSADEE RFLDAAEYGN IPVVRRMMEE CRSLNVNCVD
YMGQNALQLA VANEHLEITE LLLKKENLAR VGDALLLAIS KGYVRIVEAI LSHPSFSEGK
RLTTSPSQSE FQHDDFYAYD EDGTRFSQDI TPIILAAHCQ EYEIVHTLLR KGARIERPHD
YFCKCTECSE KQKHDSFSHS RSRINAYKGL ASPAYLSLSS EDPVMTALEL SNELAVLANI
EKEFKNDYKK LSMQCKDFVV GLLDLCRNTE EVEAILNGDV DTNGGNVELD GRPSLCRLKL
AIKYEVKKFV AHPNCQQQLL SIWYENLSGL RQQTTAVKFL VVLAVAMGLP FLAMVYWIAP
CSKLGKIMRG PFMKFVAHAA SFTIFLGLLV MNAADRFEGT KILPNESLTD NAKQLFRMKT
SCFSWMELLI ISWVIGMIWS ECKEIWSQGP REYMFELWNI LDFGMLAIFA ASFIARFMAF
WHASRAQNYV DDDESIKDLS SATLPPEIKY YTLARIKWLP SDPQIISEGL YAIAVVLSFS
RIAYILPANE SFGPLQISLG RTVKDIFKFM VIFIMVFVAF MIGMFNLYSY YLGAKQNDAF
TTVEESFKTL FWAIFGLSEV KSVVINYGHK FIENIGYVLY GVYNVTMVIV LLNMLIAMIN
NSFQEIEDDA DVEWKFARAK LWFSYFEEGR TLPVPFNLVP SPKSFVYIAL KVKGFLNKRF
PCNSKGLQED SEMNKLGHSK HSSIRSSEDG NLNHISHPPT RYQKIMKRLI KRYVLKAQID
KESDEVNEGE LKEIKQDISS LRYELLEEKS HNTEDLAELI RKLGERLSIE PEPEQNKG
//
