ID F6VG36_XENTR Unreviewed; 526 AA.
AC F6VG36;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Enhancer of mRNA-decapping protein 3 {ECO:0000256|ARBA:ARBA00015797};
DE AltName: Full=YjeF domain-containing protein 1 {ECO:0000256|ARBA:ARBA00032192};
GN Name=edc3 {ECO:0000313|Ensembl:ENSXETP00000023279};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000023279};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000023279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000023279};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000023279}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the EDC3 family.
CC {ECO:0000256|ARBA:ARBA00006610}.
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DR AlphaFoldDB; F6VG36; -.
DR Ensembl; ENSXETT00000023279; ENSXETP00000023279; ENSXETG00000010622.
DR AGR; Xenbase:XB-GENE-5890820; -.
DR Xenbase; XB-GENE-5890820; edc3.
DR eggNOG; KOG2585; Eukaryota.
DR HOGENOM; CLU_026194_0_0_1; -.
DR TreeFam; TF324695; -.
DR Bgee; ENSXETG00000010622; Expressed in blastula and 12 other cell types or tissues.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR CDD; cd01737; LSm16_N; 1.
DR Gene3D; 2.30.30.100; -; 1.
DR Gene3D; 3.40.50.10260; YjeF N-terminal domain; 1.
DR InterPro; IPR025762; DFDF.
DR InterPro; IPR019050; FDF_dom.
DR InterPro; IPR025609; Lsm14-like_N.
DR InterPro; IPR034107; Lsm16_N.
DR InterPro; IPR047575; Sm.
DR InterPro; IPR004443; YjeF_N_dom.
DR InterPro; IPR036652; YjeF_N_dom_sf.
DR PANTHER; PTHR13612:SF0; ENHANCER OF MRNA-DECAPPING PROTEIN 3; 1.
DR PANTHER; PTHR13612; UNCHARACTERIZED; 1.
DR Pfam; PF16598; Edc3_linker; 1.
DR Pfam; PF09532; FDF; 1.
DR Pfam; PF12701; LSM14; 1.
DR Pfam; PF03853; YjeF_N; 1.
DR SMART; SM01199; FDF; 1.
DR SMART; SM01271; LSM14; 1.
DR SUPFAM; SSF64153; YjeF N-terminal domain-like; 1.
DR PROSITE; PS51512; DFDF; 1.
DR PROSITE; PS52002; SM; 1.
DR PROSITE; PS51385; YJEF_N; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..526
FT /note="Enhancer of mRNA-decapping protein 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030169559"
FT DOMAIN 18..89
FT /note="Sm"
FT /evidence="ECO:0000259|PROSITE:PS52002"
FT DOMAIN 207..243
FT /note="DFDF"
FT /evidence="ECO:0000259|PROSITE:PS51512"
FT DOMAIN 301..505
FT /note="YjeF N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51385"
FT REGION 104..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 57916 MW; BF9BA739E957B04B CRC64;
MAACSRKCEG THLLHILLLY NMAADWLGSI VSINCGNTLG VYQGCVSAVD QINQTISLTQ
PFHNGVKCLV PEVTFRAGDI SELKILEIPS ESLKFTSDQL NDHSTGFGYL PSRQQNGTSK
QKPTVAQSTA QNIPGREEGK ATEPSSSSPQ PCSKSYIDRH SEAANQPKNF RRRHNSWSSS
SRYPNQVTPK KSGTKNGQMK ARDDECFGDD LEEIPDTDFD FEGNLALFDK AAVFEEIDTH
ERRGGGGGAR SRGTPNERPP TYRHDENILE SEPIVYRKIV VPQSGGKEYC TDSGLVVPSI
SYVLHKKLLC VAEKHGLSVE RRLEISGVCA SQMALTLLGG PNRLNPKNVH QRPTVALLCG
PHVKGAQGIS CGRHLANHDV DIILFLPNFV KMLEPVTNEL NLFCQTQGKQ VSSVKDLPEC
PVDLVINCLD CNENSFLRDQ PWYRAAVDWA NQNRAPVLNI DPPVGDHVQG IHAKWSLELG
LPLALGEQAG RIYLCDIGIP QKVFREAGIS YHSPFGCKFV IPLHSM
//
