ID F6VHF7_XENTR Unreviewed; 2740 AA.
AC F6VHF7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN Name=itpr1 {ECO:0000313|Ensembl:ENSXETP00000011267};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000011267};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000011267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000011267};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000011267}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR Ensembl; ENSXETT00000011267; ENSXETP00000011267; ENSXETG00000005153.
DR AGR; Xenbase:XB-GENE-920765; -.
DR Xenbase; XB-GENE-920765; itpr1.
DR eggNOG; KOG3533; Eukaryota.
DR HOGENOM; CLU_000206_1_0_1; -.
DR InParanoid; F6VHF7; -.
DR TreeFam; TF312815; -.
DR Reactome; R-XTR-114508; Effects of PIP2 hydrolysis.
DR Reactome; R-XTR-139853; Elevation of cytosolic Ca2+ levels.
DR Reactome; R-XTR-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR Reactome; R-XTR-418457; cGMP effects.
DR Reactome; R-XTR-5578775; Ion homeostasis.
DR Reactome; R-XTR-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR Bgee; ENSXETG00000005153; Expressed in brain and 13 other cell types or tissues.
DR ExpressionAtlas; F6VHF7; baseline.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF2; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 4.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU368044}; Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2269..2291
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2303..2321
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2349..2367
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2387..2414
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2435..2457
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2561..2584
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 119..173
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 238..294
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 386..442
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 1145..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1750..1777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1871..1902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2678..2719
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1874..1902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2740 AA; 312088 MW; A8D428151DC29A8A CRC64;
MSPGAAAMSD KMSSFLHVGD IVSLYAEGSV NGFINTLGLV DDRCVVQPDA GDLNNPPKKF
RDCLFRLCPM NRYSAQKQFW KAAKPGASST TDTVLLNKLH HAADLEKKQN ETENRKLLGT
VIQYGNVIQL LHLKSNKYLT VNKRLPALLE KNAMRVTLDE AGNEGSWFYI QPFYKLRSIG
DSVVIGDKVV LNPVNAGQPL HASSHQLADN PGCNEVNSVN CNTSWKIVLF MKWSDNKDDI
LKGGDVVRLF HAEQEKFLTC DEHRKKQYVF LRTTGRQSAT SATSSKALWE VEVVQHDPCR
GGAGYWNSLF RFKHLATGHY LAAEVNPDYE AGCLESEVSI DAEPDGGNAR MQMVPEKMMC
TLISVPEGND ISSIFELDPT TLRGGDSLVP RNSYVRLRHL CTNTWVHSTN SPIDKDEEKP
VMLRIGTSPV KEDKEAFAIV PVSPAEVRDL DFANDASKVL SSIAGKLEKG TITQNERRSV
TKLLEELVYF VTGLVNAGQD ILEVLVNKPN RERQKLMREQ NILKQIFKLL QAPFTDSGDG
PMLRLEELGD QRHAPFRHIC RLCYRVLRHS QQDYRKNQEY IAKQFGFMQK QIGYDVLAED
TITALLHNNR KLLEKHITAA EIDTFVSLVR KNREPRFLDY LSDLCVSMNK SIPVTQELIC
KAVLNPANAD ILIETKLVLS RFEFEGVASG ESPLETGEDE EEVWLFWRDS NKEIRSKSVR
ELAQDAKEGQ KEDQDVLNYY RYQLNLFARM CLDRQYLAIN EISGQLDVDL ILRCMSDENL
PFDLRASFCR LMLHMHVDRD PQEQVTPVKY ARLWSEIPSE IAIDDYDSSG TSRDDIKERF
AQTMEFVEEY LRDVVGQRFP FADKEKNKLT FEVVNLARNL IYFGFYNFSD LLRLTKILLA
ILDCVHLIAN FPSSKMGKGE ESKGGSNVMR SIHGVGELMT QVVLRGGGFL PMTPMAAPEG
TIKAQREPEK EDILVMDTKL KIIEILQFIL NVRLDYRISC LLCIFKSEFD ESNAQSVEGS
TEATTVVPGT LDFEHIEEQA EGIFGGRKEN TPLDLDDDGG RTFLRVLLHL TMHDYPPLVS
GALHLLFRHF SQRQEVLQAF KQVQLLVTSQ DVDNYKQIKQ DLDQLRSIVE KSELWVYKGS
GPEEVTEAQA GGADKETPGK SKKSESTSSY NYRVVREILL RLSKLCVQEN TTGRRNRKQQ
QRLLRNMGAH SVVLELLQIP YEKTEDTRMQ EIMKIAHEFL QNFCAGNQQN QALLHKHINL
FLTPGILEAV TMQHIFMNNF QLCSEINERV VQHFAHCIET HGRNVQYIKF LQTIVKAEGR
FIKKCQDIVM AELVNSGEDV LVFYNDRASF QTLVQMMRSE RERMDENSPL MYHIHLVELL
AVCTEGKNVY TEIKCNSLLP LDDIVRVVTH EDCIPEVKIA YINFLNHCYV DTEVEMKEIY
TSNHMWKLFE NFLVDICRVC NSTSDRKHAD IVLERYVTET VMSIVNTFFS SPFSDQSTTL
QTRQPVFVQL LQAIFRVYHC NWLLPSQKAS VESCIRVLSD VAKSRAIAIP VDLDSQVNNL
FLKSHNIVQK TAMSWRMSVR NAARRDSVLT ASRDYRNIIE RLQDIVSSLE DRLRPLVQAE
LSVLVDVLHR PELLFPENTD ARKKCESGQF ICKLIRHTKL LLEENEEKLC IKVLQTLREM
MAKDRGFGDK LVALDAVESS ESPKLHGSEE EHVQAQPLRQ LEDIKRGEAL RVILVNRYYG
NIRPAGRRES LTSFGNGPLS GGGSGKSGGG GIGSGTLSRG EMSLSDVQCH LDKQGASDLV
IDLIMNATSD RVFHESILLA IALLEGGNTT IQHSFFCRLT EDKKSEKFFK VFFDRMKVAQ
QEIKATVTVN TSDLGSKKRD EEQSERETPH RKRVREPSGQ ITEEAKEQLI EASVATKKAY
NSFRREADPD DHFSLGEGMM AASEKGRDEL EMSAVITIMQ PILRFLQLLC ENHNRDLQNF
LRCQNNKTNY NLVCETLQFL DCICGSTTGG LGLLGLYINE KNVALINQTL ESLTEYCQGP
CHENQNCIAT HESNGIDIIT ALILNDINPL GRKRMDLVLE LKNNASKLLL AIMESRHDSE
NAERILYNMR PKELVEVIKK AYLQGEVEFE DGESGEDYAA SPRNVGHNIY ILAHQLARHN
KELQHMLKPG VQTGEGDEAL EFYAKHTAQI EIVRLDRTME QIVFPVPSIC EFLTKESKLR
IYYTTERDEQ GSKIHDFFQR SEDLFNEMNW QKKLRAQHVL YWCSRNMTFW SSISFNLAVL
MNLLVAFFYP FVNVHGGTLD SRLSGLLWTA MMVSLAIVIV LPKPHGIRAL IASTILRLIF
SIGLQPTLFL LGAFNVCNKI IFLTSFVGNR GTFTRGYGAM VLDVEFLYHL LYLMICAMGV
FVHEFFYSLL LFDLVYREET LLNVIKSVTR NGRSIILTAV LALILVYLFS IVGYLFFKDD
FILEVDRLHN ETIFPENGGT MTSELLYSEV CRLGSDTNCT QELSQVTEEE EEEKEHTCET
LLMCIVTVLS HGLRSGGGVG DVLRKPSKEE PLFAARVIYD LLFFFMVIII VLNLIFGVII
DTFADLRSEK QKKEEVLKTT CFICGLERDK FDNKTVTFEE HIKEEHNMWH YLFFIVLVKV
KDSTEYTGPE SYVAEMIKER NLDWFPRMRA MSLVSSDSEG EQNELRNLQE KLESTMRLVT
NLSSQLSELK DQMTEQRKQK QRIGLLGQPA HLNINPQQPA
//
