ID F6VP11_MACMU Unreviewed; 655 AA.
AC F6VP11;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 03-MAY-2023, entry version 77.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 2 {ECO:0000313|EMBL:AFH28176.1};
GN Name=FGD2 {ECO:0000313|EMBL:AFH28176.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFH28176.1};
RN [1] {ECO:0000313|EMBL:AFH28176.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thymus {ECO:0000313|EMBL:AFH28176.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; JU471372; AFH28176.1; -; mRNA.
DR RefSeq; NP_001253617.1; NM_001266688.1.
DR AlphaFoldDB; F6VP11; -.
DR GeneID; 719329; -.
DR KEGG; mcc:719329; -.
DR CTD; 221472; -.
DR HOGENOM; CLU_011755_2_1_1; -.
DR OrthoDB; 5385125at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15741; FYVE_FGD1_2_4; 1.
DR CDD; cd13386; PH1_FGD2; 1.
DR CDD; cd13236; PH2_FGD1-4; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035941; FGD1-4_PH2.
DR InterPro; IPR037797; FGD2_PH1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF82; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 102..290
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 319..418
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 458..518
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 544..641
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 20..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 74986 MW; AB5DD7CDCDF7A0F1 CRC64;
MKEASEEKLA SVSNLVTVFE NSRTPEAAPR GHRLEDAHHH PECRPPRSPG PWEKLNVGEA
MGSEPRTVSG RYLNSLKNKL SSGAWRKSCQ PVTLSGSGMQ EPEKKIVQEL LETEQAYVAR
LHLLDQVFFQ ELLRAARRSK AFPEDVVRVI FSNISSIYQF HSQFFLPELQ RRLDDWTANP
RIGDVIQKLA PFLKMYGEYV KNFERAAELL ATWTEKSPLF QEVLTRIQSG EASGSLTLQH
HMLEPVQRIP RYELLLKEYV QKLPAQAPDR ADAQKALDMI FSAAQHSNAA ITEMERLQDL
WEVYQRLGLE DDIVDPSNTL LREGPVFKIS FRRNDPMERY LFLFNNMLLY CVPRVIQVGA
QFQVRTRIDV AGMKVRELMD AEFPHSFLVS GKQRTLELQA RSQEEKISWM QAFQAAVDQI
EKRNETFKAA AQGPEGDTQE QELQSEELGL RAPQWVRDKM VTMCMRCQEP FNALTRRRHH
CRACGYVVCA RCSDYRAELK YNDNRQNRVC LHCYTFLTGN VLPEAKEDKR RGILEKGSSA
TPDQSLMCSF LQLIGDKWGK SGPRGWCVIP RDDPLVLYVY AAPQDMRAHT SIPLLGYQVT
VGPQGDPRVF QLQQSGQLYT FKAETEELKG RWVKAMERAA SGWSPSWPND GDLSD
//
