ID F6VPE5_ORNAN Unreviewed; 839 AA.
AC F6VPE5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Prominin 1 {ECO:0008006|Google:ProtNLM};
GN Name=PROM1 {ECO:0000313|Ensembl:ENSOANP00000022015.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000022015.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000022015.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022015.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000022015.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022015.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the prominin family.
CC {ECO:0000256|ARBA:ARBA00006058}.
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DR AlphaFoldDB; F6VPE5; -.
DR Ensembl; ENSOANT00000022019.3; ENSOANP00000022015.3; ENSOANG00000013966.3.
DR GeneTree; ENSGT00530000063586; -.
DR Proteomes; UP000002279; Chromosome 4.
DR Bgee; ENSOANG00000013966; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008795; Prominin.
DR PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR PANTHER; PTHR22730:SF3; PROMININ-1; 1.
DR Pfam; PF05478; Prominin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..839
FT /note="Prominin 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5028005942"
FT TRANSMEM 98..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 839 AA; 93241 MW; 227EDCE8EC8D4E8D CRC64;
MAIELFFLLL ILCGSTVPAD SSHKTSSGTL DFGYLPAGNY DTNAHYEPGP IEILFRVVHG
FLYIVQPNPF PQDLVRKIAQ QRFEHSKTDY QKAVYYEIGF IISAGLGLLF ILLLPLVGLC
FCLCRCCDNC GGEMHQRQKK NGDCQRGCFA TSLFVSSLII SIGVLCAYAA NQHLTTQVRG
AKKLVNSNFK DLRVLVTDTP GQIDYLLSQY NTTKNKALAD LNNIGPLLGG RVQERLAKQV
LPALDAALTM AGAIRETKEA LENVSASMEI LQEGTDKLNA NLTDVKMNLS NTLNDSACTT
AQAASTCNVI RNSLNQLDIN ANFSRLPGVG LQLSKVNEVL KVDLSGLVQK GYAAFNETPD
LVQNQTKNIL SDVKSILDTI GSNITSLTKM VPLEKMLKDF TNYLSQTEAY IEDYFPAIEQ
YDFYRWLGCL IICCLVVLIL VFYYLGLLCG ACGYDKHTTP TNRGCVSNTG GNFLMAGVGF
SFLFSWALMI IVVFTFVSGG NMEKLVCEPF EDKTLFQVLD TPYLLNGQWK NYLSGLLFQN
PNINLTFEQV YSDCKENKGI YTSLQLDNIF NVSAFLNISV YTEDLTVQFE SIKINLSNIV
LLDETGKENL LNFSFSGIDG IDFAAYLAEV NKSITKVDLL SFSNDLEARA EQLPKGALEN
ALKGHANSIR MIHRQQVIPM EQAMKYVKAR STLNQSIRLL QKTATELMVQ VSQVIATVDA
AQLLINNNAS FIIIQETKKY MDSIIGYFEQ YVQWVKDSIT MDVASCKPIA NIIDTVVEIF
LCSYVTDSVN SFWFGLGGST IFLIPAIIFA VKLSKHYRRM DSEDVYDDSS VSGTWHFTL
//
