ID F6VXC4_XENTR Unreviewed; 961 AA.
AC F6VXC4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=MCF.2 cell line-derived-transforming sequence {ECO:0000313|Ensembl:ENSXETP00000039704};
GN Name=mcf2 {ECO:0000313|Ensembl:ENSXETP00000039704};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000039704};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000039704}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000039704};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000039704}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6VXC4; -.
DR Ensembl; ENSXETT00000039704; ENSXETP00000039704; ENSXETG00000018322.
DR AGR; Xenbase:XB-GENE-949776; -.
DR Xenbase; XB-GENE-949776; mcf2.
DR eggNOG; KOG4240; Eukaryota.
DR HOGENOM; CLU_007130_1_0_1; -.
DR TreeFam; TF318080; -.
DR Bgee; ENSXETG00000018322; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
FT DOMAIN 79..195
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 616..796
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 808..930
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 935..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 961 AA; 111580 MW; FED966342969738B CRC64;
MASPDTFRIS AVEMEKYYSL QQAAALLDTA LEKMAVPIPA KDIADLLMKE LAFLSGGRGK
DNGWIITLPE NATFNEFPES VLQKVLTYLT SIPSKQGSDV KFIVILDRRL DTWTSVRSTL
QKLSHSFPGN LHLVLVLRPT GFFQRTFTDI GFRFSQEDFL LKLPVVMLSS ASDLLHYIDE
KQLTPEFGGT FDYRHSDWVI CRTAIEGFAL TVKEIAQRLQ SFGTELAETE LPRDVYSIEH
ILAVRNEKYF QLKEGIMSVM REGSLLLNSL DGPTPTLVEE GQHCEKNGDW ETVQRLLAQL
HEMETAFDGF WEKHQLKMEQ YLELLKFEQH FEELKNGTEY LRSQHENIPD TGDNASEVRQ
RLMDLSNLEE RSQELIRRSQ MVILHGHQLA VNHHYALNLI CQQCNELRHM SDVLSEEIKR
KYAQLSTTLE LHTRLQQVTE CCDKGAYFLA NQQMDKCQSK EGAHKALLDL EKFLENASPY
STYDPQTLEY EYESILTDEL KTQIQSVHNK IENVRGLFEN RQSCLKKLAD KQARPVQLVA
PRPETPSRAK SPLFSPKHGM DFNSTLKFSF DITLPGKRTT RKIQTTRKIE VMHDYQERRN
SLQLFISESE DSLDILKGHV IHELIETERI YVEELYTVLL GYRSEMENPA MMHFMPQSLR
NMKNILFGNM PEIYEFHNKV FLQSLESCIE APEKVGFCFL ERREDFQMYE KYCQNKPRSD
SLWRQFSDSV FFQECQKKLD HKLALDSYLL KPVQRLTKYQ LLIKELLKYS SNADGAEELQ
EALDSMLDLL KSVNDSMHQI AITGYNGDIN ELGRILMQGS FSVWITHKKG ATKMKELARF
KPMQRHLFLY ERALVFCKKR EEHGDGHDKT PSYSFKHILK MNAVGITENV KGDSRKFEIW
YSGREEVYIV QAQTSEQKTA WLNEIRKILT RQQEHMKGTV QKQKPNASTD QLSFSPQMNE
R
//
