ID F6W1F9_XENTR Unreviewed; 1166 AA.
AC F6W1F9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=EMILIN-2 {ECO:0000313|RefSeq:XP_012820783.1};
DE SubName: Full=Elastin microfibril interfacer 2 {ECO:0000313|Ensembl:ENSXETP00000003398};
GN Name=emilin2 {ECO:0000313|Ensembl:ENSXETP00000003398,
GN ECO:0000313|RefSeq:XP_012820783.1,
GN ECO:0000313|Xenbase:XB-GENE-978931};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000003398};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000003398}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000003398};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000003398}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_012820783.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_012820783.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_012820783.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012820783.1; XM_012965329.3.
DR Ensembl; ENSXETT00000003398; ENSXETP00000003398; ENSXETG00000001613.
DR GeneID; 100491397; -.
DR KEGG; xtr:100491397; -.
DR AGR; Xenbase:XB-GENE-978931; -.
DR CTD; 84034; -.
DR Xenbase; XB-GENE-978931; emilin2.
DR eggNOG; ENOG502QV5P; Eukaryota.
DR HOGENOM; CLU_011705_0_0_1; -.
DR OMA; PAWPGWT; -.
DR OrthoDB; 5349070at2759; -.
DR TreeFam; TF331033; -.
DR Reactome; R-XTR-2129379; Molecules associated with elastic fibres.
DR Proteomes; UP000008143; Chromosome 6.
DR Bgee; ENSXETG00000001613; Expressed in 4-cell stage embryo and 13 other cell types or tissues.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR PANTHER; PTHR15427:SF5; EMILIN-2; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF07546; EMI; 1.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..1166
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157368"
FT DOMAIN 49..125
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 1015..1164
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 125..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 174..201
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 271..305
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 599..626
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 789..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..822
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..923
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1166 AA; 128578 MW; 6CAFC5355DA7FA40 CRC64;
MIPFRAMQSG GAAPAPRSSA PLLLALLCAV LVLSGATPPL TYQRSGQKGK NWCAYIINKN
VSCTVMDGTE SFIQPQYRCA WNQIHCQPTM AYRVGFRPRY TTSYKVVTEL EWRCCPGFKG
VDCKDGPSEE AKSIPLQTSR PAAGSKDTGN KGIGGKDIGT GINRQKPQEA KGQLQELQNL
NEAQEKKIHF LEDEMLRLTQ TVIDMQTSLA GVNENLKITI QEDVSKNLVS WLNNLPRPES
FSGGKTETIT FQGFSGSTEK EDGVRDIISE LNSMKEALQS KSLLIDKLNE KLNGYEESLR
QFQEASHGPA PTIHTVSAPE NSIEEKLEAL RDEMLDGMDR KMADLKNSCD YKLTSVQQQC
EDHETSCLGV IELLREKETQ LRKEINAVKS QGGIQGNGQS CCTNNGDLDS KIKHLDQKVE
RISEAHKVLN SRIDNEIQRI NSLSPDSIYE ERLTELDFKI NITEKNAEEH CFYIEETLRG
LITTNSNEMK DLDTRLQKME DVVWDIVNAS SPDVVHSSVG STAHHGPGSV SGHLVTEIRD
LKDAVHQLEG QMFSILHTNV DYSNHNDGHK ENDNFILLKS LNDTINEKFD LIQLNKVGIE
TVRGDLHKLN HKLNSYEEDV NLLKDGVSLF NNQILDIKAT VKNTESGLHK KVGEVERLCK
DTSYSAANNE CCSGLQSKFE LLSSEITADK GTCTKHTQGI QKEMSNVDAR LSKLENVCGK
LDTISGSMQR IKDGLNKHVT SLWNCIHTIN GTVKSHSNDI YGLKNSVQVF HSQVSKITSD
LDNLIKSQPA VGNEPEQTFQ TRITPPLPPR EPQKPAYPQV PQQPVIPQDS QIPQQPVIPQ
IPQYPTQHKV TEPATQPKLP QMPSGSKPNQ QPSQPRQPFL PDSSVIVIPV HPGSDGVIVE
TGQAGPPGRM SKTESRQPQG SNEQEAILMS TGSAARILKS GSQRPHGADG QQDMSVSKGF
AGAPGYPEKH LNARDQAKRP GASASQDPFN IPAFSEAQEN LKVSAFSESQ GATTTTTALI
SFSVGLNGDR ESFEDGVIQF NNVLVNDGEH YNPETGIFTA PIEGRYMITA VLTPEQDYHV
EAVLSVSNKS VAQMDTSGYR RERLEYNKPG RPICGGVGTF HLILHLKSGD EVSIEQIGGK
LASSSTEEMY STFSGVFLYP YSSSYR
//
