ID F6W2J1_HORSE Unreviewed; 882 AA.
AC F6W2J1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO5A1 {ECO:0000313|Ensembl:ENSECAP00000013936.2,
GN ECO:0000313|VGNC:VGNC:23293};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013936.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000013936.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013936.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000013936.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013936.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR AlphaFoldDB; F6W2J1; -.
DR STRING; 9796.ENSECAP00000013936; -.
DR MEROPS; I01.972; -.
DR PaxDb; 9796-ENSECAP00000013936; -.
DR Ensembl; ENSECAT00000017186.3; ENSECAP00000013936.2; ENSECAG00000016284.4.
DR CTD; 81796; -.
DR VGNC; VGNC:23293; SLCO5A1.
DR GeneTree; ENSGT01080000257410; -.
DR HOGENOM; CLU_008954_1_1_1; -.
DR InParanoid; F6W2J1; -.
DR OMA; GMNCLAQ; -.
DR OrthoDB; 2874223at2759; -.
DR TreeFam; TF317540; -.
DR Proteomes; UP000002281; Chromosome 9.
DR Bgee; ENSECAG00000016284; Expressed in gluteus medius and 12 other cell types or tissues.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR CDD; cd17404; MFS_SLCO5_OATP5; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF142; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 199..221
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 264..285
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 306..330
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 350..371
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 505..526
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 681..705
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 717..738
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 769..793
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 133..794
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 582..635
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 882 AA; 96100 MW; 2E19503BB5DDA25E CRC64;
MDEGTGLQPQ AGEQLQAPAT VGAFQEKCEP ETFRSKSLPV LNSTSCRPDL SPASVDAKPA
VGCTDSLCQQ ELKQGPSRLA PSPSAPCTSA EMAGLVDCNH RVDVIKTVSV SSALATLQGR
RCLYVVLTDS RCFLVCMCFL TFIQALMVSG YLSSVITTIE RRYSLKSSES GLLVSCFDIG
SLVVVVFVSY FGGRGRRPLW LAVGGLFIAV GAALFALPHF ISPPYQIQEL NASASNDGLC
QSGNSTAALE PAACLTDSGG NNHWVYVALF ICAQILIGMG STPIYTLGPT YLDDNVKKEN
ASLYLAIMYV MGALGPAVGY LLGGLLIGFY VDPRNPVHLD QNDPRFIGNW WSGFLLCAIA
MFLVIFPMFT FPKKLPPRHK KRKKKKFSGD VASDDDVMKE KPNNSEQVDK KVSSMGFGKN
VRDVYACICI FLQRFTSFVN KSISWSSFYA STDLPRAAVR ILSNLTFLFV SLSYTAESAI
VTAFITFIPK FIESQFGIPA SNASIYTGVI IVPSAGVGIV LGGYIIKKLK LGARESAKLA
MICSGVSLLC FSTLFIVGCE SINLGGINIP YTTGPSLTMP HRNLTGSCNV NCGCKTHEYE
PVCGSDGITY FNPCLAGCVN SGNLSTGIRN YTECTCVQSR QVITPPTVGQ RSQLRVVIVK
TYLNENGYAV SGKCKRTCNT LIPFLIFLFI VTFITACAQP SAIIVTLRSV EDEERPFALG
MQFVLLRTLA YIPTPIYFGA VIDTTCMLWQ HECGVQGSCW EYNVTSFRFV YFGLAAGLKF
VGFVFIFLAW YSIKYKEDEL QRRRWREFPL STVSEMVGRP DTAAEKYART RSCPAISTQG
EFHEETGLQK GTQYTAQTYP GPFPEAISPS PDPGLEESPA AM
//