ID F6WML7_ORNAN Unreviewed; 2980 AA.
AC F6WML7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSOANP00000013564.2};
GN Name=CENPF {ECO:0000313|Ensembl:ENSOANP00000013564.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000013564.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000013564.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000013564.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9258.ENSOANP00000013564; -.
DR Ensembl; ENSOANT00000013567.2; ENSOANP00000013564.2; ENSOANG00000008524.3.
DR eggNOG; ENOG502QVMD; Eukaryota.
DR GeneTree; ENSGT00730000111187; -.
DR HOGENOM; CLU_000551_0_0_1; -.
DR OrthoDB; 5363462at2759; -.
DR TreeFam; TF101133; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000008524; Expressed in fibroblast and 7 other cell types or tissues.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874:SF10; CENTROMERE PROTEIN F; 1.
DR PANTHER; PTHR18874; CMF/LEK/CENP CELL DIVISION-RELATED; 1.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 1..321
FT /note="Centromere protein Cenp-F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1931..2050
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2169..2314
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2830..2874
FT /note="Kinetochore protein Cenp-F/LEK1 Rb protein-binding"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 152..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2758..2841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2869..2980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..117
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 182..209
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 287..452
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 481..615
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 644..766
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 837..892
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 918..1008
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1041..1128
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1165..1363
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1590..1687
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1869..1903
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1935..2025
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2054..2472
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2526..2571
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2615..2724
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1759..1780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2809..2833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2869..2916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2931..2946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2958..2980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2980 AA; 341873 MW; F6153D2F2AA4C583 CRC64;
MSWAVEEWKE GLSTRALQKI QELESQLDKL KKERQQRQFQ LESLEAALQK QKQKVENEKT
EAATLKRENQ SLMEMCDNLE KTRQKISHDL QVKESQVNYQ EGQLNSSKRQ IEKLELELKR
THLYCGYLLE VWGWKDSRCK SELERGQQAL LPGDSSLSVS STPQKSFTAP LTPSQYHNDA
KYKELQEKYN KEVEERKRLE AEVKVMQVQK MNQALPQSTV NHREIARHQT SSSVFSWQQE
KTPNRFSANI QETPLKRGFS ACHFPWEQEE TPNKPERKEA NTSICDNSCN SQLMDQLKAQ
NQELRSEVSE LERLLQGQEK DMKGHMNKLQ EIQIQLEKTR LELMEKDKTL SKSRDELTRT
AAQLDQALDK GTMLEQKMKK MSEELSCQRQ NAESARCSLE QKIKEKEKEY QEELSRQQRS
LQGLDQELTQ IKAKLSQELQ QAKNAHNALQ AEFDKMVSVK LQLEKSSDEL TQKLYRTEQA
LQASQTQEND LRRNFEGMKQ EKDILRNQTD QKEREVRHLE EELKETKKCL KQSQNFAEEM
KDQNASREAM LKTLQEKLTQ QENSLTLEKL KLAVADLEKQ REFSQDLLKK REHHIEQLNN
KLSRVERESE TIMSALGLKE KECEELKRET VLFSQWKSEN EQLLNQLGAD KERLQSTINN
LEVRLQNQQL KNHEEKERIK IMENEKESFS VEMKNLQKKM EGKSAELEAQ KLAYAELQQK
AECSDRKYKK EIENMSWKIA QLTGQVEELE EKLQSESNEA LERAQRYHEL QADYEKISKL
VKFKDDSALM TADDCRPLLV FEQQSMMNNS PTDVVIGEKQ SFFLGETGQS TDLSLGVGKY
EKNVALLQEK VSSLEISLET QKQLNIDLQT QCEELVKIKA EIEENLIKAE QMHQSFVAET
NQRVSKLQED TSAQQNVVNE ALVALEDREK QLQTLNEKLE TGQVEIQDLK TNNKLLEDSI
KQLHLVSETL SSEKKEMSGI LTLKEEEIED LTKENGNLKQ LNATLHQEKI NLVQENLTIS
NCVAEREKNI SELSKSYNEQ RLALCQRCEE AEKDLRIIQE KYKSLEERNM NLECVANEHS
SNLEVRKYEL EQLESALAKE RKEYQCRLVS SEEKNRNLIQ ELDRVQGAFK AEIEEIQNVS
QVEISSLRQD ISDFKALQST MQEKHDALLR ENEKLMEANQ IKDEEQRREL TLVENLTAEQ
IKESVEEKEK ELNQFQVQLE VLQQDLKARD IAVDSYSIKV GVLEAAVKTL EHRLRESESE
KETLQQEMQL IKGELKASDS KFQEVQLKDQ SLDLSAYEDS KREMDEKYAS ILQELSSSQN
DNEQLLASLQ ATKSKLSKLE KMYEMLQIEK LELTSALNES KSECIMAEEV EKMVNDVKTP
IKENIVCQDD CMEQSGKDDV GEPTGEPELE SLKLQGSDVE GSAADYENLK LSNQKVQMHF
VELQDKFSTL QSEHKILYDQ HCTMSSKMSE LQSYINTLKA ENSVLSANLK NINPDLVSQV
SPTKGDFELG ESEPLFSTPS VKEIPSLTSC VESSFYKNLF DQTGESSLLT SLAENSLENQ
VRADIELAHC SPGTDNRTKK DIETDLEMKI KELETLCQVH QQSMKKLQDK LENQEMMKND
EIQTLKQLLC SERKELDCLR KQCSSENEQW QQKLTSLTLE MESKLAAEKK QTEHLSLELE
VARLQLQGLD LSSRSLLCAR IEDTTLAENE SSGLGDSEEN ILGPEEEIQK DGDLQTKIPC
DVKQEGSPKN EAGTVLPGIG SGEQTSEIKG GTSPVRNSEP SECYSELSFC SQETSLAPMD
FLENQVSIQN MQVKHIPNEN LNLLQDAEES DKKEDKLLSE IKELDPKMDL QKQELTAKSG
SHRELAKLVL LLEREKSGLN EKVESLSCEN QQLSHKVAVL EKLNSELEIC EVRVADVTAI
NDDIAVAERV WKEKCLEIEK ELKRVKSEKA NVENHALTME SDFEELQTQR RNLENDNENK
RETITSLQEQ LSVITSERNQ LTEELNALSE EKAIVGQDCE KLKEKIKDFE TSEEESIRHI
QRVESEVKEK TVLVQALSSD INHLSRDKDC LQSQLQNLDK TMQAFILEKE ELQKQTKQLN
EEKELLLQEL ETVQTKLSSS EGEIVKLSTS LKGSQIEKGE IAARLNSTQE EVHQMRNGIE
KLKMHIEADE KEKQHITGKL KESERKADSL QDKIEALERQ LQMAEENQEA MILDAETAKM
EAETLKTKIE ELTGRLQGLE LEFGALRLEK ENVIEEKETI AKDLQEKQDR MSELESCNSS
FEKLLENKEQ EIVRMEEESK NAIELLQVQL KDLKDKIETL LSEHKAYKVT EHDLISQVDD
LERDKVQLLQ QLEETQSNNA SLDLSLKDLI QELEGHKQKL GEKMAENEVL LIQVKDAEQL
SLKLSQIENE RDLWEKERVD LQNRTMELEH KNQVLSKNET LRDTLEALQS SYKNLENVLE
LTKAEKLALL EKVNAMTENN TILQRKMSDT IQNMTVLQEE FTGEKNGLIE KVMVMEKQAE
MNKVQIDKIT LENSNLKKSL DCVQKELKEK EVKMAEEITE YQSRLNEADK KHQAILMDAN
EQHKIEIQAY QDKLNSTDQC LNLQRLEMNI LRTSKEELTH SLKTTNQVLE ELQKTKVDNL
KYVAQLKKEN DSIRGKLQML LKSCKQLEKE KGALQKEMTE REALQKQKQS PAASVRLEEL
MAQLKDLKEA FEEKSKEADE NLDKYCSLIV NYNKLEEANE MLKTQVFLLN SQLSQPVKRT
LRSSPSQCAG HAAKSPVHLD GEKTTPKGGN KLSGKRSRPH GTKDSFGGSE PCTPETSSKR
LRKGMTPSLR SSDHSDCELP GLPEIVQKGF ADIPTGKTSP YVLRRTTLPT RTSPRLAAQK
LSPSTQCSQK SPLKNLVETS KPTAGGSRSQ KVTEAQAHTA GLLAARMGST GRSPLSVNNL
SKKISAGSPR ETLKAKKGRP ATNQQLSSEP NQQDENCRVQ
//
