ID F6WUF3_XENTR Unreviewed; 1137 AA.
AC F6WUF3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Par-3 family cell polarity regulator beta {ECO:0000313|Ensembl:ENSXETP00000027122};
DE SubName: Full=Partitioning defective 3 homolog B isoform X1 {ECO:0000313|RefSeq:XP_002936439.2};
GN Name=pard3b {ECO:0000313|Ensembl:ENSXETP00000027122,
GN ECO:0000313|RefSeq:XP_002936439.2,
GN ECO:0000313|Xenbase:XB-GENE-5816818};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000027122};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000027122}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000027122};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000027122}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002936439.2}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002936439.2};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002936439.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR RefSeq; XP_002936439.2; XM_002936393.5.
DR Ensembl; ENSXETT00000027122; ENSXETP00000027122; ENSXETG00000012407.
DR GeneID; 496480; -.
DR KEGG; xtr:496480; -.
DR AGR; Xenbase:XB-GENE-5816818; -.
DR CTD; 117583; -.
DR Xenbase; XB-GENE-5816818; pard3b.
DR eggNOG; KOG3528; Eukaryota.
DR HOGENOM; CLU_006629_0_1_1; -.
DR OMA; YFHMDEE; -.
DR OrthoDB; 5405986at2759; -.
DR TreeFam; TF323729; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Bgee; ENSXETG00000012407; Expressed in 2-cell stage embryo and 14 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF4; PARTITIONING DEFECTIVE 3 HOMOLOG B; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 2.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 199..287
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 380..453
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 495..570
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 146..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1072..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..866
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1107
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1137 AA; 127206 MW; CF0BF746183439B4 CRC64;
MKVTVCFGKT GIVVPCKDGK MSVRELIQQA AQRFIKAKEK EPGYWVKVHH LEYQDGGILD
PDDIVADVVE DKDKIIAVFD EQEASEIKNR NEDSVNVIDR TSPDPLEAEL SAQLSAFQPL
KGEIDVTSSA LKIGTPLLVR RSSDPTVGPA VDFHPSSSQS ADQNVNDASQ GLSRVLPPDE
QTDQNTGLQK PLYKIREITR KVEISGSGGP LGIHVVPFYS SFSGRALGLY IRGIEESSRS
KREGLFQENE CIVKINNVEL IDRSFAQAQD IFRQAMKQQN VLVETVLPEK RELYEKSVIS
SLFVLDDDID EVPDIKPPPP PVHVNRSIKM PEQVNGIDPT GTKIQQPPLS PNLISSESKF
SSPSLSPLGF GNKKNGKKLR IDLTKGAEGL GFTVVTRDST VHGPGPIFVK NILPKGAAVK
DGRLLSGDRI LEVNGKDIAG KTQEELVAML RSTKLGESVS LVVARQDETF LPRELKGETE
NLVFPPDNTA QMTFEIPLND SGSAGLGISL KGNKSRETGA DLGIFIKSII HGGAAFKDGR
LRVNDQLVAV NGESLLGKSN RDAMETLRRS MSMEGNIRGM IQLVILRRLD WQTEERSETF
QKNTIENLAV SEQNGVQEKL KDSSRFNDRN SENYIPPPIP PHPKEHIIVE SPKLRNVAES
QPNDSLNIKA SRSMDIVADE SNIGSLREHQ SGSPGKDFGP RLGLKKSSSL ESLQTAFAEV
KKNELPFYRP RPHMVRGRGC NESFRAAIDK SYDGPEGEEE DALSDLSSHS GRESPNSELT
PLGNQEMEDT DKSKKEKKKK DVKKEKAKAK GKEKKKKDDA EEHEKKAKKK GFGVLGRLIK
KKEEKGNQKQ GTLKEEENEV EKMKEERERI NIKHQELREQ QAKNLLGYNW SHDMEDDDMD
PNYAKVNHFQ EAPLNHNAHR PYSPPTTLPP SYPRETQVLS SEREDLYAKI NKKQQAPDKS
DSGRSTSGTA DRIQQLRMEY HQAKQEGFLM HEDDDELGRH LEYEQTWIPI RSPEASRLRY
DGMERQYASL PRHGPFQPEF MPGPSTGYNE REPPYYYDVA HITQSPKGAY SQTQAHHKAS
YRIPPYQPPQ AKGPIRQDVP PSPPQNYRLP GYNAVVRPGQ EEYQYDPRQK NPLTAAV
//
