ID F6WWB3_ORNAN Unreviewed; 571 AA.
AC F6WWB3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=TFIIS N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51319};
GN Name=LOC100088046 {ECO:0000313|Ensembl:ENSOANP00000009543.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000009543.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000009543.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000009543.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000009543.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000009543.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00649}.
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DR AlphaFoldDB; F6WWB3; -.
DR STRING; 9258.ENSOANP00000009543; -.
DR Ensembl; ENSOANT00000009545.3; ENSOANP00000009543.2; ENSOANG00000005996.3.
DR eggNOG; KOG2821; Eukaryota.
DR GeneTree; ENSGT00390000002428; -.
DR HOGENOM; CLU_021679_2_0_1; -.
DR InParanoid; F6WWB3; -.
DR OMA; NANTLAH; -.
DR OrthoDB; 4793at2759; -.
DR TreeFam; TF317259; -.
DR Proteomes; UP000002279; Chromosome 1.
DR Bgee; ENSOANG00000005996; Expressed in ovary and 1 other cell type or tissue.
DR GO; GO:0070449; C:elongin complex; IEA:InterPro.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR CDD; cd00183; TFIIS_I; 1.
DR Gene3D; 6.10.250.3180; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR010684; RNA_pol_II_trans_fac_SIII_A.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15141:SF49; TFIIS N-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15141; TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3; 1.
DR Pfam; PF06881; Elongin_A; 1.
DR Pfam; PF08711; Med26; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 6..80
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 79..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..135
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 64723 MW; 11190CD7717A2260 CRC64;
MAEAGNITHR VLQLKEHLNM ARDPKKILKA LKRLEVLEMS LDVLVETGIG KTVNGFRKHD
TAGSVAKSLV KRWKKLLPSE NGSECKGRKR DSGRGKKKLS VSKENKQSRE ESESAPREKK
RSSKAPKKRP AGTRSKPKRK EVVKPYCGLK VKDARSVRKP KDSPGRGDGT RERAPDRLCT
HTASHRDSPC KSGQRSPLAP GMLVSELTEK HAENGVEFPE GEQFEPPTMS FESYLNYDQV
PRKRKRRPSC KRGQPPPAQD TEESRPDSKR ALTPTAVRDP GIPSQKQTDQ LEKKAKTTSL
EELLNLPLPK FLPEISLVPS PPYVMEFKAP AANIPCNEPN PFTCRRLNSK MQVYSGSKTT
HLPKMLSLYV QCIRVLQNNL DSLREVGGVP FELLEPVLER CTPKQLLHIE DCNPTFMEED
DHLWMKHCQR EFKNESLLEY ESWREMYLRL FDQREQKLKI LTKNIISAQS EKPRGRQVKM
AYIHSTAKPP RDIRRQQELH GTAGLHSNKY KKRTPESRER KHSRAASSSV AATSSSPLSS
GSCQDVKRAG KKMAPMMAKS IRAFKNRVGP R
//
