ID F6X9R7_HORSE Unreviewed; 1036 AA.
AC F6X9R7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=RB transcriptional corepressor like 1 {ECO:0000313|Ensembl:ENSECAP00000021871.2};
GN Name=RBL1 {ECO:0000313|Ensembl:ENSECAP00000021871.2,
GN ECO:0000313|VGNC:VGNC:22229};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021871.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021871.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021871.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021871.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021871.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR AlphaFoldDB; F6X9R7; -.
DR STRING; 9796.ENSECAP00000021871; -.
DR PaxDb; 9796-ENSECAP00000021871; -.
DR Ensembl; ENSECAT00000026234.3; ENSECAP00000021871.2; ENSECAG00000024316.3.
DR CTD; 5933; -.
DR VGNC; VGNC:22229; RBL1.
DR GeneTree; ENSGT00950000183202; -.
DR HOGENOM; CLU_008943_0_1_1; -.
DR InParanoid; F6X9R7; -.
DR OMA; AILCELH; -.
DR OrthoDB; 519973at2759; -.
DR TreeFam; TF105568; -.
DR Proteomes; UP000002281; Chromosome 22.
DR Bgee; ENSECAG00000024316; Expressed in brainstem and 23 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:2000773; P:negative regulation of cellular senescence; IEA:Ensembl.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 3.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF20; RETINOBLASTOMA-LIKE PROTEIN 1; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR Pfam; PF08934; Rb_C; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 70..212
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 385..578
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 801..907
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 920..1036
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
SQ SEQUENCE 1036 AA; 116926 MW; 862D1AD1F59E0D60 CRC64;
MFENEPHAEG AAVVAAAREA LQALCQELNL DEGSAAEALD DFAAIRGKYS LEGEVIHWLA
CSLYVACRKS IIPTVGKGIM EGNCVSLTRI LRSAKLSLIQ FFNKMKKWMD MSNMPQEFRE
RIERLERNFE VSTVIFKKFE PIFLDIFQNP YEEPPKLPRS RKQRRIPCSV KDLFNFCWTL
FVYTKGNFRM IGDDLVNSYH LLLCCLDLIF ANAIICPNRR DLLNPSFKGL PSDFHTADFR
ASEEPPCIIS VLCELHDGLL VEAKGIKEHY FKPYISKLFD RKILKGDCLL DLSSFTDNSK
AVNKEYEEYV LTVGDFDERI FLGADAEEEI GTPRKFTGDA PLGKLTAQAN VECNLQQHFE
KKTSFAPSTP LTGRRYLREK EAVITPVASA TQSVSRLQGI VAGLKNAPSE QLINIFESCM
RNPMENIMKI VKGIGETFCQ HYTQSTDEQP GSHIDFAVNR LKLAEILYYK ILETIMVQET
RRLHGMDMSV LLEQDIFHRS LMACCLEIVL FAYSSPRTFP WIVEVLNLQP FYFYKVIEVV
IRSEEGLSRD MVKHLNGVEE QILESLAWSH NSALWEALQA SANKVPTCEE VIFPNNFETG
NGGSIQGHLP MMPVSPLMHP RVKEVRTDSG NLRRDIQPLS PISVHERYSS PTAGSAKRRL
FGEDPPKEMF IDRVITEGTK LKIASSSSIT AENLSISPGQ SLLTMSTAIV TGTTGHKVTI
PLHGIANDAG EITLIPISMN TTQESKVESS VSLTAQSLIG TSPKQTHPSK AQEVHPTGVN
KPKRTGSLAL FYRKVYHLAS VRLRDLCVKL DVSNELLRKI WTCFEFTLVH CPDLMKDRHL
DQLLLCAFYI MAQVTKEERT FQEIIKSYRN QPQANNLEDA TKTPDCSIGP VKEERADLIK
FYNTIYLGRV EAFALKYDLS NQDHVMEAPP LSPFPHIKQQ PGSPRRISQQ HSIYVSPHKN
GPGLTPRSAL LYKFNGSPSK SLKDINNMIR QGEQRTKKRA IAIDGDVESP AKRLCQENDD
VLLKRLQDVV SERANH
//
