ID F6XCW7_MONDO Unreviewed; 902 AA.
AC F6XCW7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Interleukin enhancer binding factor 3 {ECO:0000313|Ensembl:ENSMODP00000007314.3};
GN Name=ILF3 {ECO:0000313|Ensembl:ENSMODP00000007314.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000007314.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000007314.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000007314.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_001366516.3; XM_001366479.3.
DR RefSeq; XP_007488603.1; XM_007488541.2.
DR RefSeq; XP_007488604.1; XM_007488542.2.
DR RefSeq; XP_007488605.1; XM_007488543.2.
DR RefSeq; XP_007488607.1; XM_007488545.2.
DR RefSeq; XP_016287437.1; XM_016431951.1.
DR AlphaFoldDB; F6XCW7; -.
DR STRING; 13616.ENSMODP00000007314; -.
DR Ensembl; ENSMODT00000007462.3; ENSMODP00000007314.3; ENSMODG00000005911.4.
DR GeneID; 100012254; -.
DR KEGG; mdo:100012254; -.
DR CTD; 3609; -.
DR eggNOG; KOG3792; Eukaryota.
DR GeneTree; ENSGT00940000156719; -.
DR HOGENOM; CLU_015490_0_0_1; -.
DR InParanoid; F6XCW7; -.
DR OMA; PANHTQY; -.
DR OrthoDB; 4565640at2759; -.
DR TreeFam; TF320194; -.
DR Proteomes; UP000002280; Chromosome 3.
DR Bgee; ENSMODG00000005911; Expressed in forelimb bud and 20 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IEA:Ensembl.
DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0001618; F:virus receptor activity; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR CDD; cd19910; DSRM_ILF3_rpt1; 1.
DR CDD; cd19912; DSRM_ILF3_rpt2; 1.
DR Gene3D; 1.10.1410.40; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 2.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR033099; DSRM1_ILF3.
DR InterPro; IPR006561; DZF_dom.
DR InterPro; IPR049402; DZF_dom_C.
DR InterPro; IPR049401; DZF_dom_N.
DR InterPro; IPR043519; NT_sf.
DR PANTHER; PTHR45762:SF4; INTERLEUKIN ENHANCER-BINDING FACTOR 3; 1.
DR PANTHER; PTHR45762; ZINC FINGER RNA-BINDING PROTEIN; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF20965; DZF_C; 1.
DR Pfam; PF07528; DZF_N; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00572; DZF; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS51703; DZF; 1.
PE 4: Predicted;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 5..377
FT /note="DZF"
FT /evidence="ECO:0000259|PROSITE:PS51703"
FT DOMAIN 397..466
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 528..594
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 52..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 96482 MW; DC2E6D09866E5627 CRC64;
MRPMRIFVND DRHVMAKHSA VYPTQEELEA VQNMVSHTER ALKAVSDWID EQEKVSGEQP
EPEAMDVVPE EENKEGGEQK TEHLTRTLRG VMRVGLVAKG LLLKGDLDLE LVLLCKEKPT
TALLDKVADN LGVQLAAITE DKYEIIQSIG EAAIVIKNTK EPPLSLTIHL TSPVVREEME
KLLAGETLSV NDPPDVLDRQ KCLAALASLR HAKWFQARAN GLKSCVIVIR VLRDLCTRVP
TWAPLRGWPL ELLCEKSIGT ANRPMGAGEA LRRVLECLAS GIVMPDGSGI YDPCEKEATD
AIGHLDRQQR EDITQSAQHA LRLAAFGQLH KVLGMDPLPS KMPKKPKNEN PVDYTIQIPP
STTYAITPMK RPMEEDGEEK SPSKKKKKIQ KKEEKTEPPQ AMNALMRLNQ LKPGLQYKLV
SQTGPVHAPI FTMSVEVDGS SFEASGPSKK TAKLHVAVKV LQDMGLPTGA EGKDSNKGED
SAEETEQKPV VVAPPPVVET VAAPSAAFPS PDQTSENVKQ QGPILTKHGK NPVMELNEKR
RGLKYELISE TGGSHDKRFV MEVEVDGQKF QGAGSNKKVA KAFAALTALE KLFPDAPVAL
EPNKKKRAPV PVRGGPKFAA KQHNPGFGMG GPMHNEVPPP PNIRGRGRGG NIRGRGRGRG
GFGGANHGGY MNAGAGYGSY GYGGNSATAG YSQFYSNGGH SGNAGGGGGG GGGGSSGYGS
YYQGDNYNSP VPPKHGGKKQ QHGGQQKPSY GSGYQSHQGQ QQSSYSQNQY SNYGPPQGKQ
KGYNHGQGNY SSYSNSYNSP GGGGGSDYNY ESKFNYSGSG GRGGGGNSYG SGGSSYNTGS
HGGYGGSSGG GSSYQGKQGG YSSQSNYNSP GSGQNYSGPP SSYQSSQGGY GRNDHSMNYQ
YR
//
