ID F6XFV4_HORSE Unreviewed; 242 AA.
AC F6XFV4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=ELL associated factor 1 {ECO:0000313|Ensembl:ENSECAP00000021849.3};
GN Name=EAF1 {ECO:0000313|VGNC:VGNC:17391};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021849.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021849.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021849.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021849.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021849.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the EAF family. {ECO:0000256|ARBA:ARBA00007798}.
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DR AlphaFoldDB; F6XFV4; -.
DR STRING; 9796.ENSECAP00000021849; -.
DR PaxDb; 9796-ENSECAP00000021849; -.
DR Ensembl; ENSECAT00000026211.3; ENSECAP00000021849.3; ENSECAG00000024360.3.
DR VGNC; VGNC:17391; EAF1.
DR GeneTree; ENSGT00390000017724; -.
DR HOGENOM; CLU_025755_0_0_1; -.
DR InParanoid; F6XFV4; -.
DR OMA; TSPNRHP; -.
DR TreeFam; TF320864; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000024360; Expressed in inner cell mass and 23 other cell types or tissues.
DR GO; GO:0032783; C:super elongation complex; IEA:InterPro.
DR GO; GO:0008023; C:transcription elongation factor complex; IBA:GO_Central.
DR GO; GO:0003711; F:transcription elongation factor activity; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR027093; EAF_fam.
DR InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR PANTHER; PTHR15970:SF8; ELL-ASSOCIATED FACTOR 1; 1.
DR PANTHER; PTHR15970; ELL-ASSOCIATED FACTOR EAF; 1.
DR Pfam; PF09816; EAF; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 10..87
FT /note="Transcription elongation factor Eaf N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09816"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..136
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 242 AA; 25818 MW; 1743109A06CB7ED2 CRC64;
MASSSKTQDD FKPASIDTSC EGELQVGKGD EVTITLPHIP GSTPPMTVFK GNKRPYQKDC
VLIINHDTGE YVLEKLSSSI QVKKTRAEGS SKIQARMEQQ PSRPPQPSQP PPPPPPMPFR
APTKPPVGPK TSPLKDNPSP EPQLDDIKRE LRAEVDIIEQ MSSSSGSSSS DSDSSSGSDD
DSSSSGGEDN GPASPPQPSH QQPYNSRPAV ANGTSRPQGS NQLMNTLRND LQLSESGSDS
DD
//
