ID F6XP42_ORNAN Unreviewed; 570 AA.
AC F6XP42;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=CD2 associated protein {ECO:0000313|Ensembl:ENSOANP00000013160.2};
GN Name=CD2AP {ECO:0000313|Ensembl:ENSOANP00000013160.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000013160.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000013160.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000013160.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6XP42; -.
DR STRING; 9258.ENSOANP00000013160; -.
DR Ensembl; ENSOANT00000013162.2; ENSOANP00000013160.2; ENSOANG00000008279.2.
DR eggNOG; KOG4348; Eukaryota.
DR GeneTree; ENSGT00940000157566; -.
DR HOGENOM; CLU_024255_2_0_1; -.
DR InParanoid; F6XP42; -.
DR OMA; XEIKRET; -.
DR TreeFam; TF350191; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000008279; Expressed in ovary and 8 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0031252; C:cell leading edge; IBA:GO_Central.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0031941; C:filamentous actin; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0002102; C:podosome; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0001771; P:immunological synapse formation; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IEA:Ensembl.
DR GO; GO:0032911; P:negative regulation of transforming growth factor beta1 production; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0071559; P:response to transforming growth factor beta; IEA:Ensembl.
DR GO; GO:0051403; P:stress-activated MAPK cascade; IEA:Ensembl.
DR GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0032905; P:transforming growth factor beta1 production; IEA:Ensembl.
DR CDD; cd12056; SH3_CD2AP_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR035777; CD2AP_SH3_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF92; CIN85 AND CD2AP RELATED, ISOFORM J; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..59
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 108..167
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 267..328
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 459..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..499
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 570 AA; 64027 MW; 5042974284B9D4A1 CRC64;
MVDYIVEYDY DAVHDDELTI RVGEILRNVK KLEEEGWLEG ELNGKRGMFP DNFVKEIKRE
AESKDENVPL RRERQGNVAS LVQRMSTYGL PAGGFQPHPQ TKGFKKKSKK RQCKVLYQYL
PQNEDELELK VGDIIEINEE VEEGWWNGTL NSKTGLFPSN FVKELEVIDD GETPETQEDP
ESVFIGPASP LASSGNGSDL PAAPITQPKK IRGVGFGDIF KEGSVKLKSR IPSNESEEKK
PDKVCMLQLL KSQVAEIAKA ETDSKPKAKE YCRTLFPYES TNEDELSFKE GEIIHLISKD
TGELGWWKGE LNGKEGVFPD NFAAQINEQD KDFPVSQMFH FFLLIIQNAT HLLYHPKKPI
PLNKANNLRS VGIMPQGGPE KPVPPPPFSK VNGEVSAIRP KSEFEPLLKP KLESEQLPLR
PKSVELDSLA IRHSKEIDAV NFDEIGSSEN LVHLTADRPK MPRRRLPIRF NGSNSPTQSP
EKNVKLQKEE VESAKPKPLE GKKVSCGYPA VVSSSPSSPS PRPNSAVFLS PVEVKPKEET
DDGKKYSVED LRIQILELRT MVEGLRKSHE
//
