ID F6XTQ1_CIOIN Unreviewed; 330 AA.
AC F6XTQ1; A0A1W2WAI3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Glutaredoxin-3 {ECO:0000313|Ensembl:ENSCINP00000003944.3};
GN Name=LOC100186125 {ECO:0000313|Ensembl:ENSCINP00000003944.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000003944.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000003944.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; EAAA01001727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002127851.1; XM_002127815.4.
DR AlphaFoldDB; F6XTQ1; -.
DR STRING; 7719.ENSCINP00000003944; -.
DR Ensembl; ENSCINT00000003944.3; ENSCINP00000003944.3; ENSCING00000001956.3.
DR GeneID; 100186125; -.
DR KEGG; cin:100186125; -.
DR GeneTree; ENSGT00550000075030; -.
DR HOGENOM; CLU_026126_12_2_1; -.
DR InParanoid; F6XTQ1; -.
DR OMA; CEPCTAV; -.
DR OrthoDB; 1038at2759; -.
DR TreeFam; TF314151; -.
DR Proteomes; UP000008144; Chromosome 3.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IBA:GO_Central.
DR CDD; cd03028; GRX_PICOT_like; 2.
DR CDD; cd02984; TRX_PICOT; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR033658; GRX_PICOT-like.
DR InterPro; IPR004480; Monothiol_GRX-rel.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR NCBIfam; TIGR00365; Grx4 family monothiol glutaredoxin; 2.
DR PANTHER; PTHR10293; GLUTAREDOXIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10293:SF73; GLUTAREDOXIN-3; 1.
DR Pfam; PF00462; Glutaredoxin; 2.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 3.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 2.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 1..108
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
SQ SEQUENCE 330 AA; 36895 MW; F153FE5C1322FE72 CRC64;
MGRLIHIKNE AVFSTRLEEA KKSLVVVHFW APWAEQCKQM NDVMEELAKK NTNVVFLTIE
AEELPEVSVK YEIEAVPTFI FIKNKQKIGK LNGAHAPELT KLVAQHIDTI APPTPTTTDP
KTALNNKLKS LINSAPCIMF MKGNPKEPKC GFSRTMVSIL NEHKCKYSTF DILQDQEVRQ
GLKEFSNWPT YPQLYVNGEL IGGLDIVKEM VQEGELTSAL PTQDETQTLE QQIKKIITQS
HVVLFMKGEP GAPKCGFSRQ IVQILSEAGV TYTHFDILTN EDIRQGLKKY SDWPTYPQLY
AGAELIGGLD IVKEMAQAGE LAEALTEGSA
//
