ID F6YNT4_CIOIN Unreviewed; 925 AA.
AC F6YNT4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Coronin {ECO:0000256|RuleBase:RU280818};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000009121.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000009121.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: F-actin regulator involved in anterograde Golgi to endosome
CC transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by
CC the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and
CC localizes to the trans-Golgi network, where it promotes actin
CC polymerization, thereby facilitating post-Golgi trafficking. May play a
CC role in the maintenance of the Golgi apparatus morphology.
CC {ECO:0000256|ARBA:ARBA00024838}.
CC -!- SIMILARITY: Belongs to the WD repeat coronin family.
CC {ECO:0000256|ARBA:ARBA00009482, ECO:0000256|RuleBase:RU280818}.
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DR EMBL; EAAA01001482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EAAA01001483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6YNT4; -.
DR STRING; 7719.ENSCINP00000009121; -.
DR Ensembl; ENSCINT00000009121.3; ENSCINP00000009121.3; ENSCING00000004409.3.
DR GeneTree; ENSGT00940000156606; -.
DR HOGENOM; CLU_006604_0_0_1; -.
DR InParanoid; F6YNT4; -.
DR OMA; TIMYMEV; -.
DR TreeFam; TF314280; -.
DR Proteomes; UP000008144; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031982; C:vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10856; CORONIN; 1.
DR PANTHER; PTHR10856:SF20; CORONIN-7; 1.
DR Pfam; PF08953; DUF1899; 2.
DR Pfam; PF00400; WD40; 3.
DR Pfam; PF16300; WD40_4; 2.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM01166; DUF1899; 2.
DR SMART; SM01167; DUF1900; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280818};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3..66
FT /note="DUF1899"
FT /evidence="ECO:0000259|SMART:SM01166"
FT REPEAT 74..116
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 467..532
FT /note="DUF1899"
FT /evidence="ECO:0000259|SMART:SM01166"
FT REPEAT 591..633
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 634..675
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 378..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 925 AA; 101278 MW; 380E3C0F02413BF4 CRC64;
MHRFKSSKYK NGVAKVPKKE LCITDVSVEA PVSYGNHVSC GAKFFVCNLG GAGGGKLGVF
GVDDCGRKGQ HPMLAAHAGI ITDIEFSPFY HDTFLSASDD STVKIWKIPD SGVMNSGSYS
PASVFKGFKK RPEVLQHHPV AESLCALATG GEIKLLNMKQ EDVALNCEVC SDTLQSIAWS
YDGKTIAATS KNKKLFIADP RVGQQVVETA AHGNHKDSRV ICLGDSEKFA TTGFTTSRSR
ELKAWDPRNL TSCLQTIEFG TSTGVLMPFY DADAKLIFLA GKGDSSLSIL EVVDGTELIS
QASQTMLPDQ SKGMGILPKL AVDVMSCEVD RLMQLCARQI VPVKIEVPRK SHRDFISELY
PDTDSDEIVL TAENWLSGTN GQRTKTSLDP STRKSLRVSQ NAPTVAAPAA PAEPTEPVEP
VEPAESAAQA APAAEVVKNT TPTDTKKVAS SSPPPPSESK LPAPEKKVEV HSKFRHWTGT
VLHPTTHITN IPKLNTSLSG SCDGFHINTE RVAFPLSTPG GHVAIWELSK IGRLPSSDPP
SLQNTAAVTD MRWDPFNSHR IAVGLENGKI KVWEIPEGGL KEVVSEESFS LSGHYNKVIC
VRFHPLASGI LASASSDSTI KIWDLESQEN CITLTGHEDE ILNISWSSDG KYIASMCKDN
KIRIYDPRSS TEPIKVATGS EGSSRGGRIV WACSDQLLIS SGFKSGAREI AVYDVTDMDR
GQVESQDLGG SPSTLIPHYD EDSSTLFVTG KGDTTMHSFE VSPTEPHLHQ LNTFTSDKMH
QGFLFLPKTT CDPRKVEFAR AWRLSKTTLV PISFKVPRIK MEYFQDDLFP ETRDLRKPTM
TSQQWLDGKN VQASKISVCP KDMKPLSEAP KEAPKARKYE SYDPSTYKTD EEKKEELLAA
MSNRLDLDKE LEQDTMEGVD EDEWD
//
