ID F6YQT7_MOUSE Unreviewed; 476 AA.
AC F6YQT7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Lipase, member I {ECO:0000313|Ensembl:ENSMUSP00000053447.11};
GN Name=Lipi {ECO:0000313|Ensembl:ENSMUSP00000053447.11,
GN ECO:0000313|MGI:MGI:2443868};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000053447.11, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000053447.11, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000053447.11,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000053447.11}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000053447.11};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
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DR RefSeq; NP_001239442.1; NM_001252513.1.
DR AlphaFoldDB; F6YQT7; -.
DR SMR; F6YQT7; -.
DR STRING; 10090.ENSMUSP00000053447; -.
DR ESTHER; mouse-f6yqt7; Phospholipase.
DR iPTMnet; F6YQT7; -.
DR PhosphoSitePlus; F6YQT7; -.
DR PaxDb; 10090-ENSMUSP00000053447; -.
DR ProteomicsDB; 331049; -.
DR Antibodypedia; 22161; 115 antibodies from 25 providers.
DR Ensembl; ENSMUST00000062721.11; ENSMUSP00000053447.11; ENSMUSG00000032948.11.
DR GeneID; 320355; -.
DR KEGG; mmu:320355; -.
DR UCSC; uc007zrn.4; mouse.
DR AGR; MGI:2443868; -.
DR CTD; 149998; -.
DR MGI; MGI:2443868; Lipi.
DR VEuPathDB; HostDB:ENSMUSG00000032948; -.
DR eggNOG; ENOG502QUQT; Eukaryota.
DR GeneTree; ENSGT00940000161940; -.
DR HOGENOM; CLU_027171_3_0_1; -.
DR InParanoid; F6YQT7; -.
DR OMA; CAYYFVL; -.
DR OrthoDB; 3428256at2759; -.
DR PhylomeDB; F6YQT7; -.
DR Reactome; R-MMU-1483166; Synthesis of PA.
DR BioGRID-ORCS; 320355; 1 hit in 78 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; F6YQT7; Protein.
DR Bgee; ENSMUSG00000032948; Expressed in mandible and 8 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004620; F:phospholipase activity; ISO:MGI.
DR GO; GO:0016042; P:lipid catabolic process; ISO:MGI.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR016272; Lipase_LIPH.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610; LIPASE; 1.
DR PANTHER; PTHR11610:SF103; LIPASE MEMBER I; 1.
DR Pfam; PF00151; Lipase; 1.
DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW Proteomics identification {ECO:0007829|ProteomicsDB:F6YQT7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..476
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015091134"
FT DOMAIN 55..350
FT /note="Lipase"
FT /evidence="ECO:0000259|Pfam:PF00151"
FT ACT_SITE 175
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 199
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 269
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT BINDING 213
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 218
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
SQ SEQUENCE 476 AA; 54234 MW; 4452041D4D81FFA8 CRC64;
MRIYIFLCLI CWARFGYLNF QSNTTGVSKD PEKKRTCLEF TKLSAMNSLK DLFCPKVKIN
LLMYSRGNAK CAEPLFESNN SLNTRFNPAK KTVWIIHGYR PFGSTPVWLS RFTKAFLKQE
DVNLIVVDWN QGATTFMYSR AVRNTRRVAE ILRETIENLL IHGASLDNFH FIGMSLGAHI
SGFVGKIFHG QLGRITGLDP AGPQFSRKPS NSRLYYTDAK FVDVIHTDIK SLGIGEPSGH
IDFYPNGGKH QPGCPTSIFS GTNFIKCDHQ RAIYLFLAAF ETSCNFVSFP CRSYKDYKNG
LCVDCGNLYK DSCPRLGNQA KLWKEELKKK TEEWPLRTTA FLDTSSQNPF CTYYFALNIV
ALSETMRNGS ISFGLLNDLG DLEYSTLYEK SKPFDNLQEV KILVQFVNDI VSISRICLTY
FQSTNPYCAA CQYKIQSLVL KSLTYPERPP ICKYNFVLKE GTRVDLQPDE CNTQME
//
