ID F6YZ23_MONDO Unreviewed; 4352 AA.
AC F6YZ23;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Dynein axonemal heavy chain 2 {ECO:0000313|Ensembl:ENSMODP00000009183.4};
GN Name=DNAH2 {ECO:0000313|Ensembl:ENSMODP00000009183.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000009183.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000009183.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000009183.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 13616.ENSMODP00000009183; -.
DR Ensembl; ENSMODT00000009364.4; ENSMODP00000009183.4; ENSMODG00000007423.4.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000157623; -.
DR HOGENOM; CLU_000038_4_0_1; -.
DR InParanoid; F6YZ23; -.
DR OMA; ILKNDMQ; -.
DR TreeFam; TF316836; -.
DR Proteomes; UP000002280; Chromosome 2.
DR Bgee; ENSMODG00000007423; Expressed in ovary and 12 other cell types or tissues.
DR GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR GO; GO:0036156; C:inner dynein arm; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR GO; GO:0036159; P:inner dynein arm assembly; IEA:Ensembl.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF32; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 1737..1873
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2333..2480
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2939..2973
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3142..3228
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3459..3486
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4352 AA; 499101 MW; 42BB7C78B5851226 CRC64;
MLYPLHHLAT PKWTLNFVFS TSHFRSLFRS RIVLTGLADA KWTEEHDLTL DHFIQEPLEP
IITVFIDSCA GLKLELGMSL QTQNQITYFI RQAPIPITTR NFEIIVQYGT VRGAYIPALL
RLLNGIYAPQ IFSNVSWPES IRNHFSSHLH KFLACLTDTR YKLEGHTVLY IPMEAMNMPP
EVVVKDKELV QRLETSMVHW TRQIKEVLSA QEAVDTGESL GPLEEIEFWL NRCMDLSGIS
TQLVKKGVKH IESILRLAKS TYLSPFMKLA RQIQDGSRQA QSNLTFLSIL KEPYQELAVL
QPKEIPSKFP LLLSLIRIIW VNSPYYNTRE RLTSLFRKVC DCQYHFARWQ DGKQEDMPCF
FGAQGPQVAR NLLEIEDIFH KNLHMLRAIR GGILDVKNTS WHEDYNRFRA GIKDLEVMTQ
NLITIAFETV RDVEHGVLLL DTFHRLASRE AIKRTFDKKA VDLYMIFNAE LTLVNRELSK
KWPYIPPYMG QYSGHAFWVR TLRHRLDRAM NHLTSAHFLP HIGTGEESVH AYQQLTQAMD
EMVRKTFQDW TQTVEKDSIK RLDTPLLGIS TEKPGMLNVN FDKTLLILFV EIFFWERLLF
ETPHYVVNVA ERAEDLRVLR ENLLLVARDY NRIIAMLSPD EKALFKERIR FLDKKIHPGL
KKLHWILKGA STFFINECRI HASKVQTIVN DFKGATVTIG WRAQEISETL LVRITGKRVY
QDLEFEEDQK EHRKAVQQKL ISLHEEVVDI MSESFEVFRN DGLEIQQQWW FYTMRLDHMM
EEALRLNVKW SLLELSKAIN GDGKTTPNPL FRVLVILQND GPGGGAQVEF SPTLQTLANV
VNSIASHLIN TISVFQHLPE ILFNRKCGRE PIYITVERDE EVKKIQAQIN AGMTTNASLL
QNYLKTWDTY KEIWEINKDS FIRRYQRLNP PVSSFDADIA RYTEVANNVQ KEETVLNIQF
VLLDCAHLKF SLVQHCNEWQ NKFTTLLKEM AAGRLLELHT YLTENSTKIS HPPQTLEELG
FSLNLMETLQ HDMTTMEAQI PPIHEQFAIL EKYEVQVPEN VLEMLESLDS EWLSFQQVLV
DSEQMLKRHK EKFKTGLIHS ADDFKKKAHA LLEDFDSKGP FTSSVGFAGA LEQIAAMRAM
LANMREEENT LHSNLGIFKI EQPPSKDLQN LEKELDALQQ VWEITRDWEE NWSQWKTGQF
LTLQTETMEN MAHGLFRRLT KLGKEYKDRN WDIIETTRSK IEQFKRTMPL ISDLRNPALR
ERHWDQVKDE IQRVFDQESD SFTLEQIVEL GMDQHVEKIG EISASATKEL AIEVALQNIA
KTWDVTQLDI VPYKDKGHHR LRGTEDVFQA LEDNQVALST MKASRFVKAF EKEVDLWERC
LSLILEVIEM VLTVQRQWLY LENIFLGEDI RKQLPQESAS FDQINQNWKT IMDRMNKDTN
ALRSTHYPGL LDKLTEMNSG LENIQRSLDM YLETKRHVFP RFYFLSNDDL LEILGQSRNP
EAVQPHLKKC FDNIKSLRMQ KMGGVSSKWE GIGMFSGDGE YIDFLHAVLL EGPVEGWLCD
VERAMRNTLR DLLRNCRIAL KKFLSKRDKW VKDWPGQMVI TSSQIQWTTD VTKSLQVAKE
RSDKKVLKVM RKKQVSVLNK YSEAIRGNLT KILRLKIVAL VTIEIHARDV IEKLYKSGLM
DVNAFEWLSQ LRFYWEKVQV GRQGGTRHLG VREGMISSPD LPYRCYMTLT TALHLHRGGS
PKGPAGTGKT ETTKDLGKAL GMYVIVVNCS EGLDYKSMGR MYSGLAQTGA WGCFDEFNRI
NIEVLSVVAQ QILSILSALA AGLTRFLFEG FEINLVWSCG IFITMNPGYA GRTELPDNLK
SMFRPISMVV PDSTLIAEII LFGEGFGNCK VLAKKVYTLY SLAVQQLSKQ DHYDFGLRAL
TSLLRFAGKK RRLQPDLADE EVLLLSMRDM NIAKLTSVDV PLFNAIVQDL FPNIELPVID
YGKLRETIEH ELQEMKLQNT PFTMTKVIQL YETKNSRHSS MVVGCTGSAK TVTWRILQAS
LTTLCKAGDP NFNIVKEYPL NPKAVSLGEL YGEYDLNTNE WSDGILSSVM RTACADEKPD
ENMNSVMDDN KVLTLINGER ISMPEQVSLL FEVENLAVAS PATVSRCGMV YTDYGDLGWK
PYVQSWLEKR PAGEVEPLQR MFDKFINKTL TFKKENCQEL IPLPEYSGII ALCKLFSALA
TPENGVNPAD SENYVSMVEM NFIFSLIWSV CASVDEDSRK KIDSYLREIE GSFPNKDTVF
EYFVDPKMKN WISFEEKLPK SWRYPPNAPF YKIMVPTVDT VRYNHLVSAL VSSQNPILLV
GPVGTGKTSI AQSVLQTLPT SQWAVLTVNM SAQTTSNNVQ NIIESRVEKR TKGVYVPFGG
KSMITFMDDL NMPAKDTFGS QPPLELLRLW IDYGFWYDRG KQTIKYIKDM FLMAAMGPPG
GGRTVISSRL QSRFHLINMT FPTESQIIRI FGTMINQKLQ DFEEEVKPIG NVVTQATLEL
YNTVVQRFLP TPAKIHYLFN LRDISKIFQG MLRANKAFHD TKTSITRLWI HECFRVFSDR
LVDTTDAEAF VAVLNEKLGS FFDIALHNVC PNKRSPIFGD FMREPKVYED LVDLTVLKTA
METALSEYNL SPGVVQIQLV LFREAIEHIT RIVRVIGQPR GNMLLVGIGG SGRQSLARLA
SSICEYTTFQ IEVTKHYRKQ EFREDIKRLY RQAGVELKAT SFLFVDTQIA DESFLEDINN
ILSSGEVPNL YKADEFEEIQ RQIIDQAKQE QISESSDSLF AYLIERVRNN LHIVLCLSPV
GDPFRNWIRQ YPALVNCTTI NWFSEWPREA LLEVAEKYLM GVDLGPEENI HKKVAQIFVT
MHWSVANYSR KMLLELRRHN YVTPTNYLEL VSGYKKLLAE KKQELLDQAN KLRTGLFKID
ETRQKVQVMS LELEEAKQKV AEFQKQCEEY LVIIVQQKRE ADEQQKAVTA NSEKIAVEEV
KCQALADNAQ KDLEEALPAL EEAMRALESL NKKDIGEIKS YGRPPAQVET VMQAVMILRG
NEPTWAEAKR QLGEQNFIKS LIHFDKDNIS DKVLKKIGAF CAQPDFQPDI IGRVSLAAKS
LCMWVRAMEL YGRLYRVVEP KRARMNAALA QLREKQAALA EAQEKLREVA EKLEMLKKQY
DEKLAQKEEL RKKSEEMELK LERAGMLVSG LAGEKARWEE TVQGLEEELG YLVGDCLLAA
AFLSYMGPFL TNYRDEIVSQ IWVKKIQELQ VPCSPGFTFD DFLANPTQVR DWNIQGLPSD
NFSTENGIIV TRGNRWALMI DPQGQAQKWI KNMEGSKGLK IIDLQMSDYL RILEGAIKNG
MPVLLQNVQE SLDPTLSPVL NKAVTRIGGR LLIRLGEKEV DYNPDFRFYI TTKLSNPHYS
PETSAKTTIV NFAVKEQGLE AQLLGIVVRK ERPELEEQKD TLVINIAAGK RKIKELEDEI
LRLLNEATGS LLDDVQLVNT LQTSKVTAIE VTEQLETSET TEINIDTARE AYRPCAQRAS
VLFFVLNDMG RIDPMYQFSL DSYISLFILS IDKSHRSNKL EDRIDYLNEY HTYAVYRYTS
RTLFERHKLL FSFQMCAKIL ETSGKLNMDE YNFFLRGGVV LDREGQMDNP CTGWLADANW
DNITELDKLA NFHGLMNSFE QYPRDWNLWY TNSSPEKAML PSEWENACNE MQRMLIVRSL
RQDRVAFCVT SFIVSNLGSR FIEPPVLNMK SVMEDSTPRT PLIFILSPGV DPTGALLQLA
EQTGMGQRFH ALSLGQGQAP IAARLIRDGV QQGHWVFLAN CHLSLSWMPQ LDKLVEQLQV
EEPHSAFRLW LSSSPHPDFP ISILQVSIKM TTEPPKGLKA NMKRLYQLMT EIQFARCNKP
NKYKKLLFAL CFFHSVLLER KKFLQLGWNI IYGFNDSDFE VSENLLSLYL DEYEETPWDA
LKYLIAGVNY GGHVTDDWDR RLLITYINDY FCEQSINTPF FRLSVLDAYY IPKDGNLGSY
KEYISMLPGM DPPEAFGQHP NADVASQITE ARTLFETLLS LQPQITPTGS GAQSREDKVL
ELAADVKQKI PETIDYEGTR NLLALDPSPL NVVLLQEIQR YNKLMETILF SLTELEKGIH
GLVVMSTSLE EIFNSIFDAR VPHLWETAYP SQKPLASWTR DLALRVEQFA TWASRARPPV
LFWLSGFTFP TGFLTAVLQA AARQNNVSID SLSWEFIVST VDDSNLVYPP KDGVWVRGLF
LEGAGWDRKN SCLAEAEPMQ LVCPIPTIHF KPTESRKKTA KGMYSCPCYY YPNRAGCAGR
ASFVIGIDLR SGSMPSDHWV KRGTALLMSL DN
//
